Brain tissue partial pressure of oxygen predicts the outcome of severe traumatic brain injury under mild hypothermia treatment

Sun, Haitao; Mao-hua, Zheng; Wang, Yanmin; Diao, Yunfeng; Zhao, Wanyong; Wei, Zhengjun

doi:10.2147/ndt.s102929

Cited by 12 publications

(3 citation statements)

References 14 publications

(12 reference statements)

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“…[ 25 , 26 ] Regional rSO2 is a commonly used indicator for monitoring rSO2 in clinical practice, which can timely and accurately reflect the balance between oxygen supply and oxygen demand in patients’ brain tissue, and the decrease of rSO2 index indicates insufficient cerebral tissue perfusion. [ 27 ] The study from Ning JQ showed EA stimulation can increase rSO2 levels in patients with diabetes. [ 28 ] The results of this study showed that EA treatment could decrease rSO2 level and increase the score of MoCA and MMSE, indicating that EA treatment could improve the recovery of consciousness after TBI by decreasing cerebral oxygen metabolism.…”

Section: Discussionmentioning

confidence: 99%

The neuroprotective effect of electro-acupuncture on cognitive recovery for patients with mild traumatic brain injury: A randomized controlled clinical trial

et al. 2023

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Background: Traumatic brain injury (TBI) is a major health and socioeconomic problem that affects all societies. Consciousness disorder is a common complication after TBI while there is still no effective treatment currently. The aim of this study was to investigate the protective effect of electro-acupuncture (EA) on cognitive recovery for patients with mild TBI. Methods: A total of 83 patients with initial Glasgow coma scale score higher than 12 points were assigned into this study. Then patients were randomly divided into 2 groups: EA group and control group (group C). Patients in group EA received EA treatment at Neiguan and Shuigou for 2 weeks. At 0 minute before EA treatment (T 1 ), 0 minute after EA treatment (T 2 ), and 8 weeks after EA treatment (T 3 ), level of neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), hypoxia inducible factor-1α (HIF-1α), and malondialdehyde were tested by enzyme-linked immunosorbent assay. The score of Montreal Cognitive Function Assessment (MoCA) and mini-mental state examination (MMSE) as well as cerebral oxygen saturation (rSO2) were detected at the same time. Results: Compared with the baseline at T 1 , the level of NSE, GFAP, HIF-1α, MDA, and rSO2 decreased, and the score of MoCA and MMSE increased in the 2 groups were significantly increased at T 2–3 ( P < .05). Compared with group C, the level of NSE, GFAP, HIF-1α, MDA, and rSO2 decreased, and the score of MoCA and MMSE increased were significantly increased at T 2–3 in group EA; the difference were statistically significant ( P < .05). Conclusions: EA treatment could improve the cognitive recovery for patients with mild TBI and the potential mechanism may be related to improving cerebral hypoxia and alleviating brain injury.

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Section: Discussionmentioning

confidence: 99%

The neuroprotective effect of electro-acupuncture on cognitive recovery for patients with mild traumatic brain injury: A randomized controlled clinical trial

et al. 2023

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“…PbtO 2 monitoring is more helpful in reducing secondary poor brain oxygenation following severe brain trauma, so is more conducive to improving prognosis. Hongtao [ 45 ] and his team administered mild hypothermia treatment (MHT) in 68 severe TBI patients and monitored the changes in PbtO 2 , ICP, SjvO 2 , and CPP. It was found that during MHT, PbtO 2 , SjvO 2 , and CPP increased dramatically, while ICP decreased considerably.…”

Section: Cerebral Blood Oxygen Saturation Monitoring Methodsmentioning

confidence: 99%

A Review of Monitoring Methods for Cerebral Blood Oxygen Saturation

Zhong

Sun

2021

Healthcare

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In recent years, cerebral blood oxygen saturation has become a key indicator during the perioperative period. Cerebral blood oxygen saturation monitoring is conducive to the early diagnosis and treatment of cerebral ischemia and hypoxia. The present study discusses the three most extensively used clinical methods for cerebral blood oxygen saturation monitoring from different aspects: working principles, relevant parameters, current situations of research, commonly used equipment, and relative advantages of different methods. Furthermore, through comprehensive comparisons of the methods, we find that near-infrared spectroscopy (NIRS) technology has significant potentials and broad applications prospects in terms of cerebral oxygen saturation monitoring. Despite the current NIRS technology, the only bedside non-invasive cerebral oxygen saturation monitoring technology, still has many defects, it is more in line with the future development trend in the field of medical and health, and will become the main method gradually.

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“…Monitoring SvO 2 may also reflect the therapeutic effect. For example, Sun et al found the low brain tissue partial pressure of oxygen correlated with a poor outcome of severe TBI with mild hypothermia treatment ( Sun et al, 2016 ). McCredie et al found the treatment of red blood cell transfusion had no measurable impact on cerebral tissue oxygenation in severe TBI ( McCredie et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Decreased susceptibility of major veins in mild traumatic brain injury is correlated with post-concussive symptoms: A quantitative susceptibility mapping study

Chai

Guo

Zuo

et al. 2017

NeuroImage: Clinical

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Cerebral venous oxygen saturation (SvO2) is an important biomarker of brain function. In this study, we aimed to explore the relative changes of regional cerebral SvO2 among axonal injury (AI) patients, non-AI patients and healthy controls (HCs) using quantitative susceptibility mapping (QSM). 48 patients and 32 HCs were enrolled. The patients were divided into two groups depending on the imaging based evidence of AI. QSM was used to measure the susceptibility of major cerebral veins. Nonparametric testing was performed for susceptibility differences among the non-AI patient group, AI patient group and healthy control group. Correlation was performed between the susceptibility of major cerebral veins, elapsed time post trauma (ETPT) and post-concussive symptom scores. The ROC analysis was performed for the diagnostic efficiency of susceptibility to discriminate mTBI patients from HCs.The susceptibility of the straight sinus in non-AI and AI patients was significantly lower than that in HCs (P < 0.001, P = 0.004, respectively, Bonferroni corrected), which may indicate an increased regional cerebral SvO2 in patients. The susceptibility of the straight sinus in non-AI patients positively correlated with ETPT (r = 0.573, P = 0.003, FDR corrected) while that in AI patients negatively correlated with the Rivermead Post Concussion Symptoms Questionnaire scores (r = − 0.582, P = 0.018, FDR corrected). The sensitivity, specificity and AUC values of susceptibility for the discrimination between mTBI patients and HCs were 88%, 69% and 0.84. In conclusion, the susceptibility of the straight sinus can be used as a biomarker to monitor the progress of mild TBI and to differentiate mTBI patients from healthy controls.

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Brain tissue partial pressure of oxygen predicts the outcome of severe traumatic brain injury under mild hypothermia treatment

Cited by 12 publications

References 14 publications

The neuroprotective effect of electro-acupuncture on cognitive recovery for patients with mild traumatic brain injury: A randomized controlled clinical trial

The neuroprotective effect of electro-acupuncture on cognitive recovery for patients with mild traumatic brain injury: A randomized controlled clinical trial

A Review of Monitoring Methods for Cerebral Blood Oxygen Saturation

Decreased susceptibility of major veins in mild traumatic brain injury is correlated with post-concussive symptoms: A quantitative susceptibility mapping study

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