Brain Targeting of Antidepressant and Anxiolytic Drugs

Antunes, Jéssica; Paiva‐Santos, Ana Cláudia; Veiga, Francisco José; Pires, Patrícia C.

doi:10.3390/asec2022-13766

Cited by 1 publication

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“…Nanoparticles are drug delivery systems with a particle size of 10-100 nm that are generated using polymer materials as carriers to adsorb or encapsulate drugs within the carrier material (Antunes et al, 2023). Nanoparticles can protect encapsulated drugs from degradation, preventing their unintended removal from the nasal cavity, extending the residence time of drugs in the nasal mucosa, and promoting the direct transport of certain drugs from the nasal cavity to the brain, without increasing drug concentrations within the general circulation; thus, nanoparticles can help facilitate braintargeted drug delivery (Ferreira et al, 2023).…”

Section: Nanoparticlesmentioning

confidence: 99%

Research progress in brain-targeted nasal drug delivery

Huang,

Chen,

et al. 2024

Front. Aging Neurosci.

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The unique anatomical and physiological connections between the nasal cavity and brain provide a pathway for bypassing the blood–brain barrier to allow for direct brain-targeted drug delivery through nasal administration. There are several advantages of nasal administration compared with other routes; for example, the first-pass effect that leads to the metabolism of orally administered drugs can be bypassed, and the poor compliance associated with injections can be minimized. Nasal administration can also help maximize brain-targeted drug delivery, allowing for high pharmacological activity at lower drug dosages, thereby minimizing the likelihood of adverse effects and providing a highly promising drug delivery pathway for the treatment of central nervous system diseases. The aim of this review article was to briefly describe the physiological structures of the nasal cavity and brain, the pathways through which drugs can enter the brain through the nose, the factors affecting brain-targeted nasal drug delivery, methods to improve brain-targeted nasal drug delivery systems through the application of related biomaterials, common experimental methods used in intranasal drug delivery research, and the current limitations of such approaches, providing a solid foundation for further in-depth research on intranasal brain-targeted drug delivery systems (see Graphical Abstract).

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Section: Nanoparticlesmentioning

confidence: 99%