Brain targeting efficiency of Curcumin loaded mucoadhesive microemulsion through intranasal route

Mandal, Snigdha Das; Mandal, Sujit; Patel, Jayvadan

doi:10.1007/s40005-016-0227-2

Cited by 21 publications

(12 citation statements)

References 28 publications

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“…[59] Curcumin loaded mucoadhesive microemulsion can be effectively targeted to the brain through intranasal route. [60] Piperine Piperine, a major alkaloid in black pepper, is consumed by the majority of populations in the world. Later studies proved that Piperine could inhibit MDR through ABC transporter inhibitor.…”

Section: Spicesmentioning

confidence: 99%

Untitled

Sureshkumar¹

2018

AJP

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This review aims at the drug-resistant factors, its effects, and methods to overcome. P-glycoprotein (P-gp) is an energy-dependent efflux transporter which plays a leading role in multidrug resistance (MDR) of the majority of drugs and is involved in the efflux of toxins, xenobiotics, and drugs out of the body. Their unique mechanism of action put them in the spotlight for the drug discovery process. Modification of drug transporters through inhibitors, inducers or the methods of genetic polymorphism are being used recently. Uses of specific inhibitors or blockers with a parent drug have been evolved as a new method to alter MDR. These inhibitors are classified into various generations based on the properties that they exhibit. MDR is a significant obstacle resulting from the overexpression of some proteins like P-gp which reduces therapeutic efficacy of various drugs associated with cancer, tuberculosis, malaria, and human immunodeficiency virus, etc. Inhibitors of P-gp can be regarded as an explicit remedy for this puzzling condition. Although various chemical inhibitors had been developed, natural agents are comparatively safer than synthetic or semi-synthetic agents. Novel strategies and formulations are developed to alter the expression of P-gp is also mentioned in this paper.

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Section: Spicesmentioning

confidence: 99%

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Sureshkumar¹

2018

AJP

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“…In einer Studie wurde die Aufnahme von Curcumin im Hirngewebe nach Gabe einer schleimhautadhäsiven Mikroemulsion über die intransale Route mit Curcumingabe i. v. verglichen. Hierbei zeigte sich bei Albinoratten im Gehirn eine 11-fach höhere Anreicherung von Curcumin im Gewebe als nach intravenöser Gabe [5]…”

Section: Wirksamkeit: Curcumin Versus Gesamtextraktunclassified

Curcuma longa in der Onkologie

Kneer¹

2017

EHK

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ZusammenfassungCurcuma longa wird seit Jahrtausenden in der ayurvedischen und chinesischen Medizin bei zahlreichen Erkrankungen eingesetzt. Im Mittelpunkt der Forschung steht überwiegend Curcumin, ein wesentlicher Bestandteil des Extrakts. In-vitro- und In-vivo-Studien haben vielfältige Wirkmechanismen u. a. antioxidative und antiinflammatorische Wirkungen aufgezeigt. Bei zahlreichen Erkrankungen, v. a. mit entzündlicher Genese sowie bei Tumorerkrankungen, hat sich der Einsatz von Curcumin als effektiv erwiesen. Curcumin beeinflusst alle Signalwege von der Karzinogenese bis zur Metastasierung. Formulierungen mit verbesserter Bioverfügbarkeit sowie neue Applikationsformen versuchen pharmakologische Schwächen des Pflanzenstoffes auszugleichen. Aktuell werden in Patientenstudien z. B. Kombinationen mit Chemotherapien und Strahlentherapien erprobt. Daneben sind aber auch Kombinationen von Curcuma mit anderen Pflanzenstoffen zur Optimierung therapeutischer Effekte in der integrativen Onkologie von großem Interesse.

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“…Each sample (1g) was subjected to 10 times dilution with purified water before analysis. The electrode of the pH meter (Jenway 3510, UK) was immersed in the prepared solution for pH determination [13,15].…”

Section: Phmentioning

confidence: 99%

“…The viscosity of MBGs and conventional gel formulations, in centipoise (Cp), were determined at room temperature using a Brookfield viscometer (Brookfield DV model DV-II+viscometer, Brookfield Engineering laboratories, Inc., Stoughton, U. S. A) Spindle no 6 was used and rpm set at 1.5. Spindle was lowered perpendicularly into the center of MBG taking care that spindle does not touch the jar bottom [15].…”

Section: Rheological Studymentioning

confidence: 99%

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Intranasal Microemulgel as Surrogate Carrier to Enhance Low Oral Bioavailability of Sulpiride

Ayoub

Ibrahim

Abdallah

et al. 2016

Int J Pharm Pharm Sci

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Objective: The purpose of this study is to evaluate microemulsion based gel (MBG) of sulpiride "a poorly water soluble antipsychotic with low oral bioavailability."Methods: Gelling polymers such as sodium carboxymethylcellulose (CMC-Na), hydroxyl propyl methyl cellulose (HPMC K4m), carbopol 940 and Na alginate were evaluated for their potential to gel sulpiride microemulsions (MEs) without affecting the MEs structure. Also, sulpiride solution (SS) and conventional gel (without ME) were prepared and compared with MBG. Gel formulations were checked for their viscosity, pH, spreadability (S), mucoadhesive force (MF), and nasal ciliotoxicity studies. The in vitro release of sulpiride across a cellophane membrane and its permeation through the nasal mucosa in phosphate buffered saline pH 6.8 (PBS) were also performed. In addition, a pharmacodynamic study of optimized formulae compared to SS and microemulsion (ME) was evaluated in rats.Results: CMC-Na and HPMC K4m were not able to gel sulpiride loaded MEs while Na alginate gave an unclear gel with a sticky texture. Results revealed that the viscosity, mucoadhesion force, and spreadability of the MBG increased with increasing carbopol 940 concentrations. The flux was arranged as the following, MBG>conventional gel>sulpiride solution (SS). According to histopathological study, safe and non-irritant MBGs suitable for nasal administration were successfully prepared. Finally, the pharmacodynamic study indicated that intranasal sulpiride MBG had a significant effect (*P<0.001) than SS and ME administered either intravenous or intranasal.Conclusion: MBG provides signiﬁcant enhancement in nasal bioavailability not only by absorption enhancing effect of ME but also, by increasing nasal residence time

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Brain targeting efficiency of Curcumin loaded mucoadhesive microemulsion through intranasal route

Cited by 21 publications

References 28 publications

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Curcuma longa in der Onkologie

Intranasal Microemulgel as Surrogate Carrier to Enhance Low Oral Bioavailability of Sulpiride

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