Brain-targeted lycopene-loaded microemulsion modulates neuroinflammation, oxidative stress, apoptosis and synaptic plasticity in β-amyloid-induced Alzheimer’s disease mice

Guo, Yunliang; Fan, Zhongyu; Zhao, Shuo; Yu, Wei; Hou, Xunyao; Nie, Shanjing; Xu, Song; Zhao, Cheng; Han, Junting; Liu, Xueping

doi:10.1080/01616412.2023.2203615

Cited by 6 publications

(2 citation statements)

References 44 publications

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“…In addition, LME-NPs upregulated the Wnt/β-catenin pathway by upregulating Wnt3a, β-catenin, Disheveled (Dvl), and p-GSK3β and downregulating p-β-catenin and GSK3β. More recently, LME-NP supplementation dramatically decreased MDA production and restored antioxidant capacity, alleviated neuronal loss, attenuated astrocytosis and microgliosis, normalized apoptotic parameters, inhibited amyloidogenic processing, and activated the non-amyloidogenic pathway, together with upregulating synaptic protein expression and restoring synaptic plasticity [ 268 ].…”

Section: Potential Of Dietary Small Molecule-based Nanotherapy In Admentioning

confidence: 99%

Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease

Balakrishnan,

Jannat,

Choi

2024

Redox Biology

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Section: Potential Of Dietary Small Molecule-based Nanotherapy In Admentioning

confidence: 99%

Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease

Balakrishnan,

Jannat,

Choi

2024

Redox Biology

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“…It has also shown to decrease palmitic acid-induced brain oxidative stress and neuroinflammation and to inhibit the toll-like receptor 4 (TLR4)/nuclear factor kappa-light chain enhancer of activated B cells p65 (NF-kB-p65) pathway in female rats [ 156 ]. In mice with Alzheimer's disease induced by β amyloid, lycopene reduced oxidative stress, decreased neuronal loss, improved synaptic plasticity, and inhibited neuroinflammation [ 196 ].…”

Section: Biological Activities Of Lycopenementioning

confidence: 99%

Lycopene: A Potent Antioxidant with Multiple Health Benefits

Shafe,

Gumede,

Nyakudya

et al. 2024

Journal of Nutrition and Metabolism

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Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato‐based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when it is used as a dietary supplement. In vitro and in vivo, lycopene has been demonstrated to mitigate oxidative stress‐induced metabolic dysfunctions and diseases including inflammation, obesity, and diabetes mellitus. Lycopene has been shown to alleviate metabolic diseases that affect the bone, eye, kidney, liver, lungs, heart, and nervous system. This review presents the state of the art regarding lycopene’s health benefits and its potential applications in health system delivery. Furthermore, lycopene’s protective effects against toxins, safety in its use, and possible toxicity are explored.

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Self-assembled low molecular weight chitosan-bilobalide microsuspension protects hippocampal toxicity in amyloid beta(25–35) induced mice

Pramod Kumar,

Harish Prashanth

2024

Carbohydrate Polymer Technologies and Applications

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Brain-targeted lycopene-loaded microemulsion modulates neuroinflammation, oxidative stress, apoptosis and synaptic plasticity in β-amyloid-induced Alzheimer’s disease mice

Cited by 6 publications

References 44 publications

Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease

Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease

Lycopene: A Potent Antioxidant with Multiple Health Benefits

Self-assembled low molecular weight chitosan-bilobalide microsuspension protects hippocampal toxicity in amyloid beta(25–35) induced mice

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