Brain sulfide levels in anaesthesia: a comparison with hydrogen sulfide intoxication

Warenycia, Marcus W.; Reiffenstein, R. J.; Goodwin, Lorne R.; Dieken, Fred P.

doi:10.1016/0378-4274(89)90139-2

Cited by 7 publications

(4 citation statements)

References 8 publications

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“…concentration is comparable to that of its physiological levels (Warenycia et al 1989;Abe and Kimura 1996;Richardson et al 2000;Zhao et al 2001). …”

Section: Discussionmentioning

confidence: 53%

“…CBS is highly expressed in the central nervous system, liver, and kidney, whereas CSE is expressed mostly in the vascular system including thoracic aorta, tail artery, mesenteric artery, pulmonary artery, and portal vein and also in the liver, kidney, small intestine, and pancreas (Abe and Kimura 1996;Hosoki et al 1997;Bao et al 1998;Zhao et al 2001;Kimura 2002). Furthermore, H 2 S is detected in rat, human, and bovine brain tissues (50-160 μM) and also in rat and human blood (10-100 μM; Warenycia et al 1989;Abe and Kimura 1996;Richardson et al 2000;Zhao et al 2001).…”

Section: Introductionmentioning

confidence: 91%

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The vasorelaxant effect of hydrogen sulfide is enhanced in streptozotocin-induced diabetic rats

Denizalti

Bozkurt

Akpulat

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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Hydrogen sulfide (H₂S) is an endogenous gas which has potent relaxant effect in vascular and nonvascular smooth muscles. In the present study, we have investigated how streptozotocin (STZ)-induced diabetes affected the relaxant effect of H₂S in rat isolated thoracic aorta and mesenteric and pulmonary arteries. Diabetes was induced by IV injection of STZ (35 mg/kg). Insulin treatment was applied by using insulin implants. At the end of 4 and 12 weeks, the thoracic aorta and mesenteric and pulmonary arteries were isolated, and the relaxation responses to sodium hydrogen sulfide (NaHS), diazoxide, and acetylcholine were evaluated. The mRNA and protein levels of H₂S-synthesizing enzymes were also examined by RT-PCR and Western Blot. The relaxation response to NaHS in the arteries isolated from both 4 and 12 week-diabetic rats was increased when compared with that obtained from the control group. Glibenclamide inhibited the relaxation response to NaHS in the arteries isolated from either diabetic or non-diabetic group of rats. Concurrent treatment of insulin to STZ-injected rats prevented the potentiation of the relaxant effect of NaHS in the arteries. However, acetylcholine and diazoxide-induced relaxation responses were not altered in diabetic group of rats. The mRNA and protein levels of H₂S-synthesizing enzymes were also not altered in diabetic rats. STZ-induced experimental diabetes in rats resulted in the potentiation of the relaxation response to H₂S in vascular tissues. The potentiated relaxation to H₂S in diabetic arteries may play a role in vascular complications frequently seen in severe diabetes.

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“…concentration is comparable to that of its physiological levels (Warenycia et al 1989;Abe and Kimura 1996;Richardson et al 2000;Zhao et al 2001). …”

Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 91%

The vasorelaxant effect of hydrogen sulfide is enhanced in streptozotocin-induced diabetic rats

Denizalti

Bozkurt

Akpulat

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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“…More recent studies have shown that H 2 S is present in mammalian tissues up to 50–160 μ M as measured in rat, human, and bovine brain tissues in physiological conditions. The level of H 2 S in the brain after stroke is about one time more than control .…”

Section: Resultsmentioning

confidence: 96%

Aggravation of Seizure‐like Events by Hydrogen Sulfide: Involvement of Multiple Targets that Control Neuronal Excitability

Luo

Zhou

et al. 2014

CNS Neurosci Ther

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“…However, H 2 S is also produced in mammals. In 1989, Warenycia et al measured endogenous levels of H 2 S in brain tissue of anesthetized rats (1). Their initial idea was that general anesthesia might affect brain sulfide levels because signs of H 2 S poisoning resemble an anesthetized state.…”

Section: Introductionmentioning

confidence: 99%

Significance of Hydrogen Sulfide Production in the Pancreatic β-Cell

Taniguchi

Niki

2011

J Pharmacol Sci

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Abstract.Hydrogen sulfide (H 2 S) is an important signaling molecule in various mammalian cells and tissues. H 2 S is synthesized from L-cysteine and regulates several cellular and physiological phenomena (vasorelaxation, hormone secretion, and apoptosis) and multicellular events (neuro modulation and inflammatory responses). H 2 S can be produced in pancreatic β-cells by cystathionine β-synthase (CBS) or cystathionine γ-lyase (CSE). H 2 S inhibits insulin release and regulates β-cell survival. We found that glucose stimulation increased CSE expression at transcript and protein levels in mouse pancreatic islets. We also found that H 2 S protects β-cells that were chronically exposed to high glucose from apoptotic cell death. Loss of β-cell mass and failures of β-cell function are important in the pathogenesis and/or progression of diabetes mellitus; therefore, molecular analyses of the mechanisms of H 2 S production and its protective effects on β-cells may lead to new insights into diabetes mellitus.

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Brain sulfide levels in anaesthesia: a comparison with hydrogen sulfide intoxication

Cited by 7 publications

References 8 publications

The vasorelaxant effect of hydrogen sulfide is enhanced in streptozotocin-induced diabetic rats

The vasorelaxant effect of hydrogen sulfide is enhanced in streptozotocin-induced diabetic rats

Aggravation of Seizure‐like Events by Hydrogen Sulfide: Involvement of Multiple Targets that Control Neuronal Excitability

Significance of Hydrogen Sulfide Production in the Pancreatic β-Cell

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