Brain substrates underlying auditory speech priming in healthy listeners and listeners with schizophrenia

Wu, Chao; Zheng, Yingjun; Li, J; Wu, Haibo; She, Shou-zhang; Liu, S; Ning, Yuping; Li, L

doi:10.1017/s0033291716002816

Cited by 16 publications

(24 citation statements)

References 92 publications

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“…Moreover, many studies have found that the connectivity in the INS decreased, which may cause the disrupted functional integration of the brain [30]. The ROL is mainly involved in language, and Wu et al suggested that the reduction of connectivity of ROL improves the vulnerability of speech recognition to speech masking [62]. Not only that, the work also showed that the ROL is bound up with hallucination [63].…”

Section: Discussionmentioning

confidence: 99%

Identifying Brain Abnormalities with Schizophrenia Based on a Hybrid Feature Selection Technology

Qiao

Lan

et al. 2019

Applied Sciences

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Many medical imaging data, especially the magnetic resonance imaging (MRI) data, usually have a small sample size, but a large number of features. How to reduce effectively the data dimension and locate accurately the biomarkers from such kinds of data are quite crucial for diagnosis and further precision medicine. In this paper, we propose a hybrid feature selection method based on machine learning and traditional statistical approaches and explore the brain abnormalities of schizophrenia by using the functional and structural MRI data. The results show that the abnormal brain regions are mainly distributed in the supramarginal gyrus, cingulate gyrus, frontal gyrus, precuneus and caudate, and the abnormal functional connections are related to the caudate nucleus, insula and rolandic operculum. In addition, some complex network analyses based on graph theory are utilized on the functional connection data, and the results demonstrate that the located abnormal functional connections in brain can distinguish schizophrenia patients from healthy controls. The identified abnormalities in brain with schizophrenia by the proposed hybrid feature selection method show that there do exist some abnormal brain regions and abnormal disruption of the network segregation and network integration for schizophrenia, and these changes may lead to inaccurate and inefficient information processing and synthesis in the brain, which provide further evidence for the cognitive dysmetria of schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Identifying Brain Abnormalities with Schizophrenia Based on a Hybrid Feature Selection Technology

Qiao

Lan

et al. 2019

Applied Sciences

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“…Successful speech recognition under a speech-on-speech-masking condition involves multiple perceptual/cognitive processes, including target-speech detection, selective attention, sensory/working memory, and speech production. It is not surprising that speech recognition involves multiple brain regions with various perceptual/cognitive functions [ 5 – 10 ]. Although the augmented vulnerability to speech masking in people with schizophrenia may be associated with deficits of various perceptual/cognitive processes [ 5 – 7 , 11 – 14 ], it is the most important of all to know whether deficits in speech detection (the early-stage process) are the primary cause leading to deficits of speech recognition against informational speech masking.…”

Section: Introductionmentioning

confidence: 99%

“…It is not surprising that speech recognition involves multiple brain regions with various perceptual/cognitive functions [ 5 – 10 ]. Although the augmented vulnerability to speech masking in people with schizophrenia may be associated with deficits of various perceptual/cognitive processes [ 5 – 7 , 11 – 14 ], it is the most important of all to know whether deficits in speech detection (the early-stage process) are the primary cause leading to deficits of speech recognition against informational speech masking. We have recently reported that the performance in the task of target-speech detection, conducted by button-press, is poorer in people with schizophrenia than healthy listeners [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, although people with schizophrenia perform worse in speech recognition under speech-on-speech masking conditions, they can still improve their speech recognition by using some perceptual/cognitive unmasking cues, such as auditory speech primes [ 5 ] and auditory precedence-effect-induced perceptual spatial separation (PSS) between target speech and masking speech [ 7 ]. Relative to the auditory precedence-effect-induced perceptual spatial co-location (PSC) listening condition, introducing the PSS condition can facilitate selective attention to the target speech [ 7 , 15 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Schizophrenia alters intra-network functional connectivity in the caudate for detecting speech under informational speech masking conditions

Zheng

et al. 2018

BMC Psychiatry

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AbstractsBackgroundSpeech recognition under noisy “cocktail-party” environments involves multiple perceptual/cognitive processes, including target detection, selective attention, irrelevant signal inhibition, sensory/working memory, and speech production. Compared to health listeners, people with schizophrenia are more vulnerable to masking stimuli and perform worse in speech recognition under speech-on-speech masking conditions. Although the schizophrenia-related speech-recognition impairment under “cocktail-party” conditions is associated with deficits of various perceptual/cognitive processes, it is crucial to know whether the brain substrates critically underlying speech detection against informational speech masking are impaired in people with schizophrenia.MethodsUsing functional magnetic resonance imaging (fMRI), this study investigated differences between people with schizophrenia (n = 19, mean age = 33 ± 10 years) and their matched healthy controls (n = 15, mean age = 30 ± 9 years) in intra-network functional connectivity (FC) specifically associated with target-speech detection under speech-on-speech-masking conditions.ResultsThe target-speech detection performance under the speech-on-speech-masking condition in participants with schizophrenia was significantly worse than that in matched healthy participants (healthy controls). Moreover, in healthy controls, but not participants with schizophrenia, the strength of intra-network FC within the bilateral caudate was positively correlated with the speech-detection performance under the speech-masking conditions. Compared to controls, patients showed altered spatial activity pattern and decreased intra-network FC in the caudate.ConclusionsIn people with schizophrenia, the declined speech-detection performance under speech-on-speech masking conditions is associated with reduced intra-caudate functional connectivity, which normally contributes to detecting target speech against speech masking via its functions of suppressing masking-speech signals.

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“…The unmasking effect of VSP is normally based on the incorporation of several perceptual/cognitive processes, including the processing of speech information contained in lipreading, working memory of lipreading information, audiovisual integration during the co-presentation of the target speech and the masking speech, selective attention on target speech, and suppression of irrelevant masking signals (Wu et al, 2013a). People with schizophrenia, however, show impaired ability of using the temporally pre-presented lip-reading cue to improve target-speech identification against speech masking (Wu et al, 2013b), possibly suggesting a combined effect of working-memory deficits (Forbes et al, 2009), cross-modal-integration deficits (Ross et al, 2007; Wu et al, 2013b), and object-oriented-attention deficits (Zheng et al, 2016; Wu et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

Activation and Functional Connectivity of the Left Inferior Temporal Gyrus during Visual Speech Priming in Healthy Listeners and Listeners with Schizophrenia

Zheng

et al. 2017

Front. Neurosci.

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Under a “cocktail-party” listening condition with multiple-people talking, compared to healthy people, people with schizophrenia benefit less from the use of visual-speech (lipreading) priming (VSP) cues to improve speech recognition. The neural mechanisms underlying the unmasking effect of VSP remain unknown. This study investigated the brain substrates underlying the unmasking effect of VSP in healthy listeners and the schizophrenia-induced changes in the brain substrates. Using functional magnetic resonance imaging, brain activation and functional connectivity for the contrasts of the VSP listening condition vs. the visual non-speech priming (VNSP) condition were examined in 16 healthy listeners (27.4 ± 8.6 years old, 9 females and 7 males) and 22 listeners with schizophrenia (29.0 ± 8.1 years old, 8 females and 14 males). The results showed that in healthy listeners, but not listeners with schizophrenia, the VSP-induced activation (against the VNSP condition) of the left posterior inferior temporal gyrus (pITG) was significantly correlated with the VSP-induced improvement in target-speech recognition against speech masking. Compared to healthy listeners, listeners with schizophrenia showed significantly lower VSP-induced activation of the left pITG and reduced functional connectivity of the left pITG with the bilateral Rolandic operculum, bilateral STG, and left insular. Thus, the left pITG and its functional connectivity may be the brain substrates related to the unmasking effect of VSP, assumedly through enhancing both the processing of target visual-speech signals and the inhibition of masking-speech signals. In people with schizophrenia, the reduced unmasking effect of VSP on speech recognition may be associated with a schizophrenia-related reduction of VSP-induced activation and functional connectivity of the left pITG.

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Brain substrates underlying auditory speech priming in healthy listeners and listeners with schizophrenia

Cited by 16 publications

References 92 publications

Identifying Brain Abnormalities with Schizophrenia Based on a Hybrid Feature Selection Technology

Identifying Brain Abnormalities with Schizophrenia Based on a Hybrid Feature Selection Technology

Schizophrenia alters intra-network functional connectivity in the caudate for detecting speech under informational speech masking conditions

Activation and Functional Connectivity of the Left Inferior Temporal Gyrus during Visual Speech Priming in Healthy Listeners and Listeners with Schizophrenia

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