Brain structural associations with depression in a large early adolescent sample (the ABCD study®)

Shen, Xueyi; MacSweeney, Niamh; Chan, Stella W. Y.; Barbu, Miruna C.; Adams, Mark; Lawrie, Stephen M.; Romaniuk, Liana; McIntosh, Andrew M.; Whalley, Heather C.

doi:10.1016/j.eclinm.2021.101204

Cited by 17 publications

(20 citation statements)

References 61 publications

(84 reference statements)

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“…The evidence of this work suggests that CT severity may be more strongly associated with cortical surface areas and volumes, especially in front and temporo-parietal regions ( Figure 3 ). Specific reductions in cortical surface area rather than thickness have also been reported in the context of adolescent depression [ 68 ], this could reflect a common feature associated with early onset of psychiatric morbidity. Cortical surface area has been shown to be established earlier in development within a shorter window than cortical thickness [ 69 ]; adverse experiences within this earlier window could be interrupting the developmental process resulting in the surface area findings presented here.…”

Section: Discussionmentioning

confidence: 91%

Structural brain correlates of childhood trauma with replication across two large, independent community-based samples

Madden

Atkinson²,

Shen³

et al. 2023

Eur. Psychiatr.

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Section: Discussionmentioning

confidence: 91%

Structural brain correlates of childhood trauma with replication across two large, independent community-based samples

Madden

Atkinson²,

Shen³

et al. 2023

Eur. Psychiatr.

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“…We did not see evidence for an alteration in either FA or MD in the UF, the corpus collosum, or the superior longitudinal fasciculi associated with depression. In adults with depression, a number of studies have found reduced FA in the UF, and there is at least some prior evidence for reduced UF FA among adolescents with depression (Cullen et al, 2010;Shen et al, 2021), though at least two other studies in adolescents that did find reduced cingulum FA did not see reduced UF FA (Kliamovich et al, 2021;Uchida et al, 2021). As such, it is not entirely clear why we did not see evidence for reduced FA in these tracts in the current study, whether associated with current depression, cumulative depression severity, or lifetime depression diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of white matter disruptions in depressed children and adolescents is less clear, a period of particular interest given the ongoing development of white matter tracts (Lebel et al, 2019). Some studies of white matter development in children and adolescents provide evidence of reduced FA in uncinate and/or cingulum in adolescents with depression (Cullen et al, 2010; Ho et al, 2021; Kliamovich et al, 2021; Shen et al, 2021; Uchida et al, 2021), but other studies have not (Cullen et al, 2020; Ho et al, 2021; Roelofs et al, 2021). There is also some intriguing evidence that reduced FA in the dorsal cingulum and uncinate may be related to risk for depression (Huang et al, 2011; Hung et al, 2016; Keedwell et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions

Barch

Hua²,

Kandala

et al. 2022

Depression and Anxiety

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Introduction: Compared to research on adults with depression, relatively little work has examined white matter microstructure differences in depression arising earlier in life. Here we tested hypotheses about disruptions to white matter structure in adolescents with current and past depression, with an a priori focus on the cingulum bundles, uncinate fasciculi, corpus collosum, and superior longitudinal fasciculus.Methods: One hundred thirty‐one children from the Preschool Depression Study were assessed using a Human Connectome Project style diffusion imaging sequence which was processed with HCP pipelines and TRACULA to generate estimates of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD).Results: We found that reduced FA, reduced AD, and increased RD in the dorsal cingulum bundle were associated with a lifetime diagnosis of major depression and greater cumulative and current depression severity. Reduced FA, reduced AD, and increased RD in the ventral cingulum were associated with greater cumulative depression severity.Conclusion: These findings support the emergence of white matter differences detected in adolescence associated with earlier life and concurrent depression. They also highlight the importance of connections of the cingulate to other brain regions in association with depression, potentially relevant to understanding emotion dysregulation and functional connectivity differences in depression.

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“…Convergent evidence from MRI studies demonstrated structural and functional abnormalities in a variety of brain regions within adolescent MDD patients. Shen et al analyzed multiple cortical structural indices of 8,634 adolescents with FreeSurfer software and found significantly decreased global cortical metrics in frontal, limbic, and temporal areas within depressed adolescents ( 7 ). On the other hand, numerous neuroimaging studies applied resting-state functional MRI (rs-fMRI) to explore the baseline brain activity.…”

Section: Introductionmentioning

confidence: 99%

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Liu

Huang

et al. 2022

Front. Psychiatry

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BackgroundThe neurobiological basis of suicidal behaviors among female adolescents with major depressive disorder (MDD) remains largely unclear.Materials and methodsFifty-eight drug-naïve, first-episode female adolescent MDD [including 31 patients with suicidal attempt (SA group) and 27 patients without SA (non-SA group)], and 36 matched healthy controls (HCs) participated in the present study. Resting-state functional magnetic resonance imaging (MRI) was performed on each subject. The metrics of the amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were compared among the three groups. Then seed-based functional connectivity (FC) was conducted based on the ALFF/fALFF and ReHo results, which were then correlated to clinical variables.ResultsCompared with the non-SA group, the SA group exhibited increased fALFF in the bilateral insula and right precentral gyrus, and enhanced ReHo in the left superior temporal gyrus, left middle cingulate cortex, right insula, and right precentral gyrus. Relative to the HCs, the SA group demonstrated additionally reduced fALFF and ReHo in the left middle frontal gyrus. Moreover, the SA group showed increased FC between the right precentral gyrus and the left middle frontal gyrus and left insula, and between the right insula and anterior/middle cingulate cortex compared to the non-SA and HC groups. In addition, the fALFF in the left middle frontal gyrus was positively correlated with the 17-item Hamilton Depression Rating Scale scores, and the values in the fALFF/ReHo in the right insula were positively correlated with the duration of MDD within the patient group.ConclusionThese findings highlight the multiple abnormalities of the frontolimbic circuit, which may enhance our understanding of the neurobiological basis underlying female MDD with SA during adolescence.

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Brain structural associations with depression in a large early adolescent sample (the ABCD study®)

Cited by 17 publications

References 61 publications

Structural brain correlates of childhood trauma with replication across two large, independent community-based samples

Structural brain correlates of childhood trauma with replication across two large, independent community-based samples

White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions

Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

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