Brain structural and functional alterations in MDD patient with gastrointestinal symptoms: A resting-state MRI study

Liu, Penghong; Li, Gaizhi; Zhang, Aixia; Yang, Chunxia; Liu, Zhifen; Sun, Ning; Zhang, Kerang

doi:10.1016/j.jad.2020.03.107

Cited by 21 publications

(21 citation statements)

References 48 publications

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“…For example, some results showed increased activity like higher FC than HCs ( 90 ) and some exhibited decreased activity like decreased ReHo ( 91 ), FC ( 24 , 92 ), and VMHC ( 27 , 93 ). In the present study, the GI group exhibited higher ReHo values in the bilateral precuneus than the non-GI group, which was inconsistent with the previous study ( 32 ) which observed no significant difference in the precuneus between the two patient groups. Different scan parameters and sample heterogeneity (i.e., 35 years old in the previous study and 30 years old in the present study) might lead to the discrepancy.…”

Section: Discussioncontrasting

confidence: 99%

“…Moreover, other studies have observed abnormal structural and functional brain MRI data in digestive system diseases, like irritable bowel syndrome (IBS) ( 28 , 29 ), other functional bowel disorders ( 30 ), and inflammatory gastrointestinal diseases ( 31 ). A few scientists have tried to examine whether MDD patients with GI symptoms had brain imaging changes and a previous study reported that MDD patients with GI symptoms showed significantly lower gray matter volume (GMV) and regional homogeneity (ReHo) in the left middle frontal gyrus, precentral gyrus, right superior frontal gyrus, and the middle frontal gyrus, as well as higher ReHo in the left superior temporal gyrus, compared to MDD patients without GI symptoms ( 32 ).…”

Section: Introductionmentioning

confidence: 99%

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Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest

et al. 2021

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Background: Gastrointestinal (GI) symptoms are prominent in patients with major depressive disorder (MDD). Previous studies have reported brain structural and functional changes in both MDD and digestive system diseases but it remains unclear whether MDD patients with GI symptoms have brain imaging changes.Methods: We recruited 35 MDD patients with GI symptoms, 17 MDD patients without GI symptoms and 28 age-, gender-, and education-matched healthy controls. All participants were scanned by resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with regional homogeneity (ReHo).Results: The GI group showed higher total HRSD-17 scores, anxiety/somatization, weight loss, and sleep disturbance scores compared to the non-GI group. We found increased ReHo in the right inferior parietal gyrus (IPL), bilateral supplementary motor area (SMA), bilateral cerebellum Crus II, left inferior frontal gyrus (IFG), and bilateral superior medial frontal cortex (SMFC) and decreased ReHo in the right posterior cingulate cortex (PCC), bilateral cuneus, and left middle occipital gyrus (MOG) in patients with GI symptoms relative to the HCs. The GI group showed higher ReHo values in the bilateral precuneus than the non-GI group.Conclusion: MDD patients with GI symptoms showed a greater severity of symptoms than MDD patients without GI symptoms, particularly in terms of anxiety/somatization, weight loss, and sleep disturbances. Increased activity in the default-mode network might be associated with GI symptoms in MDD patients.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest

et al. 2021

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“…(2013) found similar patterns of hippocampal GMV atrophy in the prodromal phase of monophasic depression and schizophrenia. In our previous study, we observed that GM damage was more severe in first‐episode schizophrenia patients with depressive symptoms than patients without depressive symptoms (Liu et al., 2020).…”

Section: Depressive Symptoms In Schizophreniamentioning

confidence: 85%

Brain imaging features in schizophrenia with co‐occurring auditory verbal hallucinations and depressive symptoms—Implication for novel therapeutic strategies to alleviate the reciprocal deterioration

et al. 2020

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Background Auditory verbal hallucinations (AVHs) and depressive symptoms are highly prevalent in schizophrenia, and recent progress has been made in understanding the reciprocal deterioration of both symptoms through structural and functional brain imaging studies. To date, there is limited literature on this topic. In this review, we synthesized the recent literature on the neuroimaging features of schizophrenia patients with concurrent AVHs and depressive symptoms. Methods A literature search was conducted with the major databases using the keywords, mainly including schizophrenia, AVHs, depression, neuropsychiatric disorders, brain imaging, and magnetic resonance imaging. Results The existing studies have shown that AVHs and depressive symptoms reciprocally deteriorate in patients with schizophrenia, which has challenged the conventional treatment of the disease. Interestingly, repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) therapies have emerged as two efficacious brain stimulation treatments that can normalize the brain regions associated with the symptoms, as shown through functional and structural brain imaging studies. In light of these important findings, there is an urgent need to conduct in‐depth neuronal mechanistic studies to identify targets for stimulation therapy. Conclusions These new findings may elucidate the pathological mechanisms underlying schizophrenia with concurrent AVHs and depressive symptoms. Furthermore, this review has important clinical implications for developing novel therapeutic strategies to alleviate the reciprocal deterioration AVHs and depressive symptoms of schizophrenia patients.

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“…The fALFF maps were normalized by subtracting the mean value for the entire brain and then dividing by the whole-brain standard deviation. The maps were further smoothed by a Gaussian kernel at a full width half maximum (FWHM) of 6 mm [ 42 , 43 ].…”

Section: Methodsmentioning

confidence: 99%

“…Segmented images of the gray matter were preserved to assess the number of volume changes based on spatial registration, and the modulated images of the gray matter could reflect the tissue volumes for using VBM analysis. Finally, we smoothed the normalized gray matter images using an 8 mm FWHM Gaussian filter [ 42 , 43 ].…”

Section: Methodsmentioning

confidence: 99%

Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study

Cai

Zhao

et al. 2021

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Although many neuroimaging studies have reported structural and functional abnormalities in the brains of patients with cognitive impairments following stroke, little is known about the pattern of such brain reorganization in poststroke dementia (PSD). The present study was aimed at investigating alterations in spontaneous brain activity and gray matter volume (GMV) in PSD patients. We collected T1-weighted and resting-state functional magnetic resonance imaging data from 20 PSD patients, 24 poststroke nondementia (PSND) patients, and 21 well-matched normal controls (NCs). We compared the differences among the groups in GMV and the fractional amplitude of low-frequency fluctuations (fALFF). Then, we evaluated the relationship between these brain measures and cognitive assessments and explored the possible distinguisher for PSD by receiver operating characteristic (ROC) curve analysis. PSD patients showed smaller GMV in the right superior temporal gyrus and lower fALFF values in the right inferior frontal gyrus than both PSND patients and NCs, but such differences were not observed between PSND patients and NCs. Moreover, GMV in the left medial prefrontal cortex showed a significant positive correlation with the Mini-Cog assessment in PSD patients, and GMV in the left CPL displayed the highest area under the ROC curve among all the features for classifying PSD versus PSND patients. Our findings suggest that PSD patients show dementia-specific structural and functional alteration patterns, which may help elucidate the pathophysiological mechanisms underlying PSD.

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Brain structural and functional alterations in MDD patient with gastrointestinal symptoms: A resting-state MRI study

Cited by 21 publications

References 48 publications

Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest

Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest

Brain imaging features in schizophrenia with co‐occurring auditory verbal hallucinations and depressive symptoms—Implication for novel therapeutic strategies to alleviate the reciprocal deterioration

Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study

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