“…As DBS is applied to a variety of disorders, including PD [20][21][22][23] , dystonia [24][25][26] , essential tremor [27][28][29] , pain [30][31][32] , epilepsy [32][33][34] , obsessive-compulsive disorder [35][36][37][38][39] , depression [35,38,40] and stroke [41] , it is essential to understand the basic mechanisms of action. Although computational models of BG circuitry have been previously published [42][43][44] , few [45,46] have studied the use of a DBS electrode on the cells being modeled, nor have any prior studies specifically looked at the cell types through the lens of what current intraoperative microelectrode recordings tell us of human cell firing patterns in PD.…”