Brain stimulation reward and dopamine terminal fields. II. Septal and cortical projections

Prado‐Alcalá, Roberto A.; Streather, Angela; Wise, Roy A.

doi:10.1016/0006-8993(84)91089-8

Cited by 44 publications

(19 citation statements)

References 49 publications

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“…In addition, LS has strong connections with brain regions associated with reward and motivation (hypothalamus, amygdala, and VTA) (Risold and Swanson, 1997a), and is important in many behaviors associated with motivation (Olds and Milner, 1954; Prado-Alcala et al, 1984; Cazala et al, 1998). In the current study, we show that LSr afferents to LH orexin neurons are critical for the expression of cocaine preference, a behavior that relies on contextual information and reward processing (Bardo and Bevins, 2000; Cunningham et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference

2012

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Orexins (also called hypocretins) have been shown to be importantly involved in reward and addiction, but little is known about the circuitry that regulates orexin neuronal activity during drug-seeking behaviors. Here, we examined inputs to the lateral hypothalamic (LH) orexin cell field from the lateral septum (LS) using tract-tracing and Fos immunohistochemistry after cocaine (10mg/kg) conditioned place preference (CPP) in Sprague Dawley rats. We found that neurons in rostral LS (LSr) that project to LH are Fos-activated in proportion to cocaine CPP, and that inhibition of LSr neurons with local baclofen and muscimol microinjection (0.3/0.03 nmol) blocks expression of Fos in LH orexin cells and cocaine preference. In addition, using local inactivation in LS and orexin antisense Morpholinos in LH, we found that LSr influences on LH orexin neurons are critical for the expression of cocaine preference. These results indicate that LSr activates LH orexin neurons during cocaine place preference, and that this circuit is essential for expression of cocaine place preference.

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Section: Discussionmentioning

confidence: 99%

A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference

2012

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“…This finding is compatible with suggestions that serotonergic input influences events which are post-synaptic to dopaminergic terminals in these brain areas, and does not preclude possible serotonergic modulation of the mesolimbic reward system, which has been suggested to be hypoactive in depression. For, although a critical DA link in the neuronal circuitry involved in the response to rewarding stimuli has been proposed (35), the reward process is more complex than just direct activation of DA terminals and the immediate efferent projection cells (36,37).…”

Section: Discussionmentioning

confidence: 99%

Characterization of the effects of serotonin on the release of [3H]dopamine from rat nucleus accumbens and striatal slices

1988

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The effect of serotonin agonists on the depolarization (K+)-induced, calcium-dependent, release of [3H]dopamine (DA) from rat nucleus accumbens and striatal slices was investigated. Serotonin enhanced basal 3H overflow and reduced K+-induced release of [3H]DA from nucleus accumbens slices. The effect of serotonin on basal 3H overflow was not altered by the serotonin antagonist, methysergide, or the serotonin re-uptake blocker, chlorimipramine, but was reversed by the DA re-uptake carrier inhibitors nomifensine and benztropine. With the effect on basal overflow blocked, serotonin did not modulate K+-induced release of [3H]DA in the nucleus accumbens or striatum. The serotonin agonists, quipazine (in the presence of nomifensine) and 5-methoxytryptamine, did not significantly affect K+-induced release of [3H]DA in the nucleus accumbens. This study does not support suggestions that serotonin receptors inhibit the depolarization-induced release of dopamine in the nucleus accumbens or striatum of the rat brain. The present results do not preclude the possibility that serotonin may affect the mesolimbic reward system at a site which is post-synaptic to dopaminergic terminals in the nucleus accumbens.

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“…Moveable-electrode mapping studies also confirm that stimulation in the primary terminal fields of both the nigrostriatal and the mesocorticolimbic systems is rewarding [20, 21]. While there are regional differences in thresholds, response rates, and time to learn, these differences are graded across both dorsal (caudate) and ventral (accumbens, olfactory tubercle) striatum.…”

Section: Brain Stimulation Rewardmentioning

confidence: 94%

Roles for nigrostriatal—not just mesocorticolimbic—dopamine in reward and addiction

Wise

2009

Trends in Neurosciences

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424

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Forebrain dopamine circuitry has traditionally been studied by two largely independent specialist groups: students of Parkinson’s disease who study the nigrostriatal dopamine system that originates in the substantia nigra (SN), and students of motivation and addiction who study the role of the mesolimbic and mesocortical dopamine systems that originate in the ventral tegmental area (VTA). The anatomical evidence for independent nigrostriatal and mesolimbic dopamine systems has, however, long been obsolete. There is now compelling evidence that both nominal “systems” participate in reward function and addiction. Electrical stimulation of both SN and VTA is rewarding, blockade of glutamatergic or cholinergic input to either SN or VTA attenuates the habit-forming effects of intravenous cocaine, and dopamine in both nigrostriatal and mesocorticolimbic terminal fields participates in the defining property of rewarding events: the reinforcement of memory consolidation. Thus the similarities between nigrostriatal and mesolimbic dopamine systems may be as important as their differences.

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Brain stimulation reward and dopamine terminal fields. II. Septal and cortical projections

Cited by 44 publications

References 49 publications

A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference

A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference

Characterization of the effects of serotonin on the release of [3H]dopamine from rat nucleus accumbens and striatal slices

Roles for nigrostriatal—not just mesocorticolimbic—dopamine in reward and addiction

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