2016
DOI: 10.3233/jad-160719
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Brain Stimulation in Alzheimer’s Disease

Abstract: Deep brain stimulation has been successfully used in treatment of motor symptoms of Parkinson’s disease and other movement disorders. In a recent multi-center prospectively randomized study, deep brain stimulation of the fornix was administered in order to ameliorate the cognitive symptoms and clinical course of Alzheimer’s disease (AD). The study points to the possibility of modest slowing of the cognitive decline in AD in a subset of patients older than 65, while at the same time highlights the risk of stimu… Show more

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Cited by 11 publications
(9 citation statements)
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References 12 publications
(15 reference statements)
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“…Yet there is still a substantial gap between the knowledge gained from basic science and the ability to apply it to modulate memory mechanisms in humans. Therefore, despite the overwhelming number of patients with neurological disorders affecting memory, we caution against premature launching of large DBS studies in this field and advocate smaller adaptive studies where spatiotemporal variables of modulation can be changed more readily (Fried, 2015(Fried, , 2016.…”
Section: Future Directionsmentioning
confidence: 99%
“…Yet there is still a substantial gap between the knowledge gained from basic science and the ability to apply it to modulate memory mechanisms in humans. Therefore, despite the overwhelming number of patients with neurological disorders affecting memory, we caution against premature launching of large DBS studies in this field and advocate smaller adaptive studies where spatiotemporal variables of modulation can be changed more readily (Fried, 2015(Fried, , 2016.…”
Section: Future Directionsmentioning
confidence: 99%
“…More recently, biophysical factors have been suggested to induce neurogenesis. Those include ultrasound, magnetic, and deep brain electrical stimulation [25][26][27][28][29][30][31][32][33]. Ultrasound stimulation is non-invasive and can induce hippocampal neurogenesis in healthy mice [29].…”
Section: Introductionmentioning
confidence: 99%
“…Itzhak Fried commented that “it is still a mystery how massive 130 Hz stimulation of the fornix at currents of thousands of microamperes might affect these intricate networks and their deterioration. This is indeed a knowledge gap that has not been adequately addressed even in rodents” [ 67 ].…”
Section: Resultsmentioning
confidence: 99%
“…For this reason, we think that both the Kuhn and the Lozano group should have better refrained from using the correlation for patient enrollment in order to protect patients against potential unnecessary risks. More trenchantly speaking, the DBS researcher Fried commented that “the greater decline in the younger AD patients who received fornix stimulation may serve as a warning that electrical stimulation can also have detrimental effect beyond the risks of surgery” [ 67 ].…”
Section: Resultsmentioning
confidence: 99%