Brain-stem response audiometry and electronystagmographic findings in chronic toxic encephalopathy (chronic painter's syndrome)

Poulsen, P. Thue; Jensen, Janne Hartvig

doi:10.1017/s0022215100098893

Cited by 10 publications

(3 citation statements)

References 4 publications

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“…In many cases, organic solvents may affect cortical evoked potential more than brainstem evoked potentials. 23 Six female workers in an electromechanical factory who had acutely inhaled toluene vapors were studied audiometrically and with vestibular tests. The toxic vapors had been produced by a heated iron plate that had been inadvertently spread with toluene.…”

Section: Toluenementioning

confidence: 99%

Hearing: The Effects of Chemicals

Rybak

1992

Otolaryngol.--head neck surg.

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Recent studies of human beings exposed to environmental chemicals, as well as experimental animal studies, have identified a number of chemical agents that are commercial products, chemical intermediaries, waste products, or contaminants that are potentially ototoxic. The classes of compounds discussed in this review include organic solvents, asphyxiant gases, and heavy metals that are present in the environment as industrial pollutants or byproducts. Both human and animal investigations are summarized in discussing the actions of these ototoxic compounds. The suggested gaps in our knowledge are highlighted to help direct future research.

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Section: Toluenementioning

confidence: 99%

Hearing: The Effects of Chemicals

Rybak

1992

Otolaryngol.--head neck surg.

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“…In workers occupationally exposed to organic solvents, somatosensory, brainstem auditory and pattern -reversal evoked potentials were frequently abnormal, but authors of the last study claims that somatosensory evoked potentials possessed the most significant diff e re n c e 1 7 . M o re o v e r, other electrophysiologic responses may be altered by thinner consumption, such as electronystagmography 14,18,19 .…”

Section: Discussionmentioning

confidence: 99%

Thinner abuse alters peak of frequency of EEG spectra analyses

Poblano

Flores

Arteaga

et al. 2006

Arq. Neuro-Psiquiatr.

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-Study objective:The aim of the investigation was to use electroencephalography (EEG) to study whether long-term thinner abuse may result in the slowing, disorganization and asymmetry of the EEG cortical rh y t h m s . Method: Twenty-two patients attending with antecedent of thinner abuse only, and twenty two controls without alcohol, smoking, and drug abuse in the same age range and gender w e re studied. EEG re c o rding were compared by means of the analyses of peak of frequency (POF), frequency of disorganization, and asymmetry of the background activity in patients and controls at rest eyesclosed condition in electrodes P3, P4, O1, and O2. Results: Significant differences in POF among groups was observed in P3 and P4 location showing lower values in thinner abusers, but not in O1 and O2 locations. Frequencies of disorganization and asymmetry showed significantly higher pro p o rtions in thinner abusers. Bivariate correlations among POF at the four electrode location and time of thinner abuse showed significant values. However after partial correlation calculation correcting for age, significant values disappeared. Conclusion: Thus thinner abuse relates with slowing of POF in the EEG of patients with thinner abuse associated with disorganization, and asymmetry depending on time of abuse.KEY WORDS: thinner abuse, toluene exposure, electroencephalography, quantitative electroencephalography.El abuso de tíner altera el pico de frecuencia del análisis espectral del EEG RESUMEN-Objetivo: Utilizar el electroencefalograma (EEG) para estudiar si el abuso o intoxicación cróni-ca por tíner produce lentificación, desorganización y asimetría de la actividad eléctrica cort i c a l . M é t o d o :Se estudiaron 22 pacientes con antecedentes de intoxicación crónica por tíner y 22 sujetos sin antecedentes de abuso de tíner, alcohol, cigarro o drogas en el mismo rango de edad y en igual número de acuerdo al género. Se registro el EEG cuantitativo y se compararon: el promedio del pico de frecuencia (PoF), la frecuencia de desorganización de la actividad de fondo y la presencia de asimetría inter-hemisférica en la condición de reposo físico y mental entre las regiones de los electrodos P3, P4, O1 y O2. Resultados: S e e n c o n t r a ron diferencias significativas en el PoF entre los grupo estudiados en P3 y P4 observándose valo res menores en el grupo con antecedente de intoxicación crónica con tíner, sin embargo estas difere ncias no fueron observadas en O1 y O2. La frecuencia de desorganización y de asimetría fue mayor entre los pacientes con antecedente de intoxicación crónica con tíner. Las correlaciones bivariadas entre el PoF en las cuatro localizaciones y el tiempo de consumo de tíner mostraron valores significativos, sin embargo, cuando fueron corregidas por la edad desaparecieron. Conclusión: La intoxicación crónica por tíner se relaciona a una lentificación del PoF del EEG de estos pacientes asociada con desorganización y asimetría que dependen parcialmente del tiempo de consumo.PALABRAS CLAVE: abuso de tíne...

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“…Most papers described additional investigations for patients in whom CTE had already been diagnosed. Five articles described neurophysiological investigations such as EEG and event-related/evoked potentials [7,8,15,30,37], three audiological/otoneurological testing [21,28,31], and one genotyping of biotransformation enzymes [39]. Investigation of cerebral spinal¯uid [4,27], measurement of regional cerebral blood¯ow [7,16], and SPECT [6,13] were described in two articles.…”

Section: Retrieval Of Articlesmentioning

confidence: 99%

Criteria for solvent-induced chronic toxic encephalopathy: a systematic review

Hoek¹,

Verberk²,

Hageman

2000

International Archives of Occupational and Environmental Health

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In 1985, a WHO Working Group presented diagnostic criteria and a classification for solvent-induced chronic toxic encephalopathy (CTE). In the same year, the "Workshop on neurobehavioral effects of solvents" in Raleigh, N.C., USA introduced a somewhat different classification for CTE. The objective of this review is to study the diagnostic procedures that are used to establish the diagnosis of CTE, and the extent to which the diagnostic criteria and classification of the WHO, and the classification of the Raleigh Working Group, are applied. A systematic search of studies on CTE was performed, and the diagnostic criteria and use of the WHO and Raleigh classifications were listed. We retrieved 30 original articles published in English from 1985 to 1998, in which CTE was diagnosed. Only two articles did not report the duration of solvent exposure. The type of solvent(s) involved was described in detail in four articles, poorly in 17 articles, and not at all in nine articles. Tests of general intelligence were used in 19 articles, and tests of both attention and mental flexibility and of learning and memory were used in 18 articles. Exclusion, by interview, of potentially confounding conditions, such as somatic diseases with central nervous effects and psychiatric diseases, was reported in 21 and 16 articles, respectively. In only six of the articles were both the WHO diagnostic criteria and the WHO or Raleigh classifications used. In the future, parameters of exposure, psychological test results, and use of medication that possibly affects psychological test results should always be described. We list some advantages and disadvantages of the Raleigh and WHO classifications. To aid inter-study comparisons, the diagnosis of CTE should be categorized and reported according to an internationally accepted classification.

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Brain-stem response audiometry and electronystagmographic findings in chronic toxic encephalopathy (chronic painter's syndrome)

Cited by 10 publications

References 4 publications

Hearing: The Effects of Chemicals

Hearing: The Effects of Chemicals

Thinner abuse alters peak of frequency of EEG spectra analyses

Criteria for solvent-induced chronic toxic encephalopathy: a systematic review

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