Brain state-dependent alterations of corticostriatal synchronized oscillations in awake and anesthetized parkinsonian rats

Jiang, Xue; Yan, Yun‐Fei; Wang, Ke; Wei, Jing; Su, Wenting; Jia, Jinping

doi:10.1016/j.brainres.2019.04.019

Cited by 7 publications

(4 citation statements)

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“…The acute injection of L-DOPA induces a transitory increase of plasma availability of dopamine, with a relatively short half-life around 1.5 hour (Cedarbaum 1987;Dhall and Kreitzman 2016). Dopamine is also known to contribute to synchronized oscillations by acting as a key regulator of the cortico-basal-ganglia circuit (Jiang et al 2019). The sensitivity of our LFP evoked responses to a variation of dopaminergic levels may correspond to a transient restoration of this regulation by desynchronizing oscillations which were excessively synchronized in 6-OHDA animals.…”

Section: Pharmacological Challengementioning

confidence: 90%

Evoked responses to single pulse electrical stimulation demonstrate impaired striatal excitability in a rodent model of Parkinson’s disease

Gronlier

Volle²,

Coizet

et al. 2022

Preprint

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Background: Sensorimotor beta oscillations are increased in Parkinson’s disease (PD) due to the alteration of dopaminergic transmission. This electrophysiological read-out is reported both in patients and in animal models such as the 6-OHDA rat model obtained with unilateral nigral injection of 6-hydroxydopamine (6-OHDA). Current treatments, based on dopaminergic replacement, transiently normalize this pathological beta activity and improve patients’ quality of life. Objectives: We wanted to assess in vivo whether the abnormal beta oscillations can be directly linked to the striato-cortical excitability of the sensorimotor system and whether it is modulated by the pharmacological manipulation of the dopaminergic system. Methods: In the unilateral 6-OHDA rat model and control animals, we used intra-striatal and intra-cortical single-pulse electrical stimulation (SPES) and concurrent local field potentials (LFP) recordings. In the two groups, we quantified basal cortico-striatal excitability from time-resolved spectral analyses of LFP evoked responses induced remotely by intracerebral stimulations. The temporal dependance of cortico-striatal excitability to dopaminergic transmission was further tested using electrophysiological recordings combined with levodopa injection. Results: LFP evoked responses after striatal stimulation showed a transient reduction of power in a large time-frequency domain in the 6-OHDA group compared to the sham group. This observation is specific to the striatum, as no significant difference was observed in cortical LFP evoked responses between the two groups, and corresponds to an impaired striatal excitability in the 6-OHDA group compared to the controls. This PD-specific effect was observed in the striatum at least during the first 3 months after the lesion. In addition, the striatum responses to SPES during a levodopa challenge showed a transient potentiation of the decrease of responsiveness in frequencies below 40 Hz. Conclusion: The spectral properties of striatal responses to SPES show high sensitivity to dopaminergic transmission in the unilateral 6-OHDA rat model. We thus propose that this approach could be used in preclinical models as a time-resolved biomarker of impaired dopaminergic transmission capable of monitoring progressive neurodegeneration and/or challenges to drug intake.

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Section: Pharmacological Challengementioning

confidence: 90%

Evoked responses to single pulse electrical stimulation demonstrate impaired striatal excitability in a rodent model of Parkinson’s disease

Gronlier

Volle²,

Coizet

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The acute injection of L-DOPA induces a transitory increase of plasma availability of dopamine, with a relatively short half-life around 1.5 h ( Cedarbaum, 1987 ; Dhall and Kreitzman, 2016 ). Dopamine is also known to contribute to synchronized oscillations by acting as a key regulator of the cortico-basal-ganglia circuit ( Jiang et al, 2019 ). The sensitivity of our LFP evoked responses to a variation of dopaminergic levels may correspond to a transient restoration of this regulation by desynchronizing oscillations that were excessively synchronized in 6-OHDA animals.…”

Section: Discussionmentioning

confidence: 99%

“…They hypothesized possible local effects of L-DOPA specific to some cortical regions. L-DOPA is known to reduce the spontaneous beta oscillations produced by 6-OHDA animals ( Delaville et al, 2014 ; Jiang et al, 2019 ), similarly to PD patients ( Brown et al, 2001 ; Brown, 2006 ). In patients, this power reduction in beta band is correlated with improvements in motor symptoms ( Ray et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Evoked responses to single pulse electrical stimulation reveal impaired striatal excitability in a rat model of Parkinson's disease

Gronlier,

Volle,

Coizet

et al. 2023

Neurobiology of Disease

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“…Furthermore, both the acute reserpine model and chronic 6-OHDA model have exhibited enhanced beta oscillations in the basal ganglia during the activated network state [ 146 ]. Nevertheless, studies have produced ambiguous findings concerning changes in beta power in animals treated with a D1/D2 receptor blocker [ 147 ]. While some studies have reported an increase in beta band oscillations under acute pharmacologic dopamine blockade [ 148 , 149 ], others have not observed such changes [ 150 , 151 ].…”

Section: Animal Models Of Parkinson's Diseasementioning

confidence: 99%

Translating Pathological Brain Activity Primers in Parkinson’s Disease Research

et al. 2023

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Translational experimental approaches that help us better trace Parkinson’s disease (PD) pathophysiological mechanisms leading to new therapeutic targets are urgently needed. In this article, we review recent experimental and clinical studies addressing abnormal neuronal activity and pathological network oscillations, as well as their underlying mechanisms and modulation. Our aim is to enhance our knowledge about the progression of Parkinson's disease pathology and the timing of its symptom’s manifestation. Here, we present mechanistic insights relevant for the generation of aberrant oscillatory activity within the cortico-basal ganglia circuits. We summarize recent achievements extrapolated from available PD animal models, discuss their advantages and limitations, debate on their differential applicability, and suggest approaches for transferring knowledge on disease pathology into future research and clinical applications.

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Brain state-dependent alterations of corticostriatal synchronized oscillations in awake and anesthetized parkinsonian rats

Cited by 7 publications

References 50 publications

Evoked responses to single pulse electrical stimulation demonstrate impaired striatal excitability in a rodent model of Parkinson’s disease

Evoked responses to single pulse electrical stimulation demonstrate impaired striatal excitability in a rodent model of Parkinson’s disease

Evoked responses to single pulse electrical stimulation reveal impaired striatal excitability in a rat model of Parkinson's disease

Translating Pathological Brain Activity Primers in Parkinson’s Disease Research

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