Brain Signaling Systems in the Type 2 Diabetes and Metabolic Syndrome: Promising Target to Treat and Prevent These Diseases

Шпаков, А. О.; Derkach, K. V.; Berstein, Lev M.

doi:10.4155/fso.15.23

Cited by 66 publications

(45 citation statements)

References 352 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Insulin also inhibits NPY expression [63]. The similarity of the leptin and insulin effects on NPY expression is due to the fact that the main target for leptin and insulin is the 3-phosphoinositide cascade, which is believed to be involved in positive regulation of POMC production and in negative regulation of NPY and AgRP production within the ARC [65,66].…”

Section: Hypothalamusmentioning

confidence: 99%

The Regulation of the Male Hypothalamic-Pituitary-Gonadal Axis and Testosterone Production by Adipokines

Шпаков¹,

Ryzhov²,

Bakhtyukov³

et al. 2018

Advances in Testosterone Action

View full text Add to dashboard Cite

There is evidence that the mass and metabolic status of the adipose tissue that produces adipokines significantly affect the activity of the hypothalamic-pituitary-gonadal (HPG) axis and the synthesis of testosterone. This is due to the fact that adipokines, such as leptin, adiponectin, visfatin and resistin have an important role in the regulation of the male HPG axis and steroidogenesis in the testes. The regulation of the HPG axis by adipokines can be carried out both through the changes the plasma levels of adipokines (a systemic regulation) and through the changes in the expression and activity of adipokines in the pituitary and testes, the components of the HPG axis (an autonomous regulation). This review presents the comprehensive analysis of the involvement of leptin, adiponectin, resistin and visfatin in the regulation of the male HPG axis and the testosterone production, as well as of the possible mechanisms of this regulation. The role of adipokines in the dysregulation of the male reproductive system and the impaired steroidogenic activity in the testes in obesity and type 2 diabetes mellitus are also discussed.

show abstract

Section: Hypothalamusmentioning

confidence: 99%

The Regulation of the Male Hypothalamic-Pituitary-Gonadal Axis and Testosterone Production by Adipokines

Шпаков¹,

Ryzhov²,

Bakhtyukov³

et al. 2018

Advances in Testosterone Action

View full text Add to dashboard Cite

show abstract

“…In these hypotheses, physical strength, social ranking and thereby reproductive opportunities play a more important role than obesity. A definite role of brain and neuronal circuits is being highlighted by a number of recent studies (29)(30)(31). In an ancestral environment, physical fitness is expected to play a role in deciding behavioural and reproductive strategies and therefore a change in metabolic and neuroendocrine make up may follow loss of physical fitness.…”

Section: Discussionmentioning

confidence: 99%

A multidimensional functional fitness score is a stronger predictor of type 2 diabetes than obesity parameters in cross sectional data

Patil

Lalwani

Vidwans³

et al. 2019

Preprint

View full text Add to dashboard Cite

Objective: We examine here whether multidimensional functional fitness is a better predictor of type 2 diabetes as compared to morphometric indices of obesity such as body mass index (BMI) and waist to hip ratio (WHR).Research design and method: We analysed retrospective data of 663 volunteer participants (285 males and 378 females between age 28 and 84), from an exercise clinic in which every participant routinely undergoes a health related physical fitness (HRPF) assessment consisting of 15 different tasks examining 8 different aspects of functional fitness.Results: The odds of being diabetic in the highest quartile of BMI were not significantly higher than that in the lowest quartile in either of the sexes. The odds of being a diabetic in the highest WHR quartile were significantly greater than the lowest quartile in females (OR = 4.54 (1.95, 10.61) as well as in males (OR = 3.81 (1.75, 8.3). In both sexes the odds of being a diabetic were significantly greater in the lowest quartile of HRPF score than the highest (males OR = 10.52 (4.21, 26.13); females OR = 10.50 (3.53, 31.35)). HRPF was not correlated with BMI in both sexes but was negatively correlated with WHR. After removing confounding, the predictive power of HRPF was significantly greater than that of WHR.Conclusion: Multidimensional functional fitness score was a better predictor of type 2 diabetes than obesity parameters in the Indian population.

show abstract

“…Respecto a sus funciones se han descrito tres grupos grandes de actividades: en primer lugar, en el sistema nervioso como neurotransmisor, en los sistema endocrino e inmune como una hormona, y a nivel paracrino en la regulación del metabolismo de los carbohidratos. A nivel neuroendocrino se debe resaltar que esta monoamina no atraviesa la barrera hematoencefálica (10) aunque tiene actividad Na + K + ATPasa en los astrocitos (8), lo que permite que participe en el control de la conducta alimentaria, la actividad motora, los estados de conciencia y de ánimo, la actividad sexual y los patrones de aprendizaje (11). Las alteraciones de la 5HT a nivel cerebral pueden llevar a cambios en la longevidad y función neuronal llevando a fenómenos neurodegenerativos, y en últimas desencadenar enfermedades neuropsiquiátricas (11).…”

Section: Fisiología De La Serotoninaunclassified

Rol del sistema serotoninérgico en la diabetes mellitus y sus dianas farmacológicas

Flórez

Montaño

2018

Rev. Médica Sanitas

View full text Add to dashboard Cite

Revisión no sistemática de la literatura que aborda el rol del sistema serotoninérgico en la fisiopatología de la diabetes mellitus y las dianas farmacológicas relacionadas. Se describen la bioquímica y la fisiología de la 5-hidroxitriptamina (5HT), su transportador y las familias y subtipos de receptores 5HT en la acción reguladora del metabolismo de los carbohidratos, la secreción de insulina y glucagón, y el control del apetito en coactivación con la leptina. Se incluyeron estudios relacionados con el papel de la serotonina en el síndrome carcinoide y complicaciones vasculares diabéticas, así como estudios sobre la medición de metabolitos (ácidos 5-hidroxindolacético y ácido xanturénico) como potenciales biomarcadores de la diabetes. Finalmente se presenta la evidencia sobre el efecto hipoglucemiante de tres grupos de medicamentos reguladores del metabolismo de la serotonina: los inhibidores selectivos de la recaptación de serotonina, los agonistas de receptores 5HT y los antagonistas de receptores 5HT y de las enzimas 5-triptófano-hidroxilasa (Tph).

show abstract

Brain Signaling Systems in the Type 2 Diabetes and Metabolic Syndrome: Promising Target to Treat and Prevent These Diseases

Cited by 66 publications

References 352 publications

The Regulation of the Male Hypothalamic-Pituitary-Gonadal Axis and Testosterone Production by Adipokines

The Regulation of the Male Hypothalamic-Pituitary-Gonadal Axis and Testosterone Production by Adipokines

A multidimensional functional fitness score is a stronger predictor of type 2 diabetes than obesity parameters in cross sectional data

Rol del sistema serotoninérgico en la diabetes mellitus y sus dianas farmacológicas

Contact Info

Product

Resources

About