Brain serotonin transporter binding, plasma arachidonic acid and depression severity: A positron emission tomography study of major depression

Gopaldas, Manesh; Zanderigo, Francesca; Zhan, Serena; Ogden, R. Todd; Miller, Jeffrey M.; Rubin‐Falcone, Harry; Cooper, Thomas B.; Oquendo, María A.; Sullivan, Gregory M.; Mann, J. John; Sublette, M. Elizabeth

doi:10.1016/j.jad.2019.07.035

Cited by 28 publications

(13 citation statements)

References 89 publications

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“…Glycerophospholipid can be catalysed by phospholipase A2 to produce AA ( 36 ). AA metabolism has also been associated with depression severity ( 37 , 38 ). AA is one of the most abundant polyunsaturated fatty acids (PUFAs) in vertebrates, and can affect depression severity through modulating 5-HTT binding potential ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

“…AA metabolism has also been associated with depression severity ( 37 , 38 ). AA is one of the most abundant polyunsaturated fatty acids (PUFAs) in vertebrates, and can affect depression severity through modulating 5-HTT binding potential ( 37 ). AA is metabolised to potent signalling molecules, including leukotrienes and prostaglandins, that mediate responses to physiological stresses, such as inflammation, and play an important role in the immune inflammation mechanism of depression ( 39 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

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The antidepressant effects and serum metabonomics of bifid triple viable capsule in a rat model of chronic unpredictable mild stress

Zhang

Guo

et al. 2022

Front. Nutr.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The antidepressant effects and serum metabonomics of bifid triple viable capsule in a rat model of chronic unpredictable mild stress

Zhang

Guo

et al. 2022

Front. Nutr.

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“…Arachidonic acid is implicated in mood disorders, and elevated levels of this fatty-acid (relative to other fatty-acids) have been linked to depression ( 34 ). A recent neuroimaging study suggests a direct effect of arachidonic acid on brain serotonin transporters, which in turn correlated with depression severity ( 35 ). Therefore, by inhibiting arachidonic acid metabolism, aspirin might interfere with serotonin systems involved in mood regulation.…”

Section: Discussionmentioning

confidence: 99%

Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial

et al. 2021

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Late-life depression is common and often inadequately managed using existing therapies. Depression is also associated with increased markers of inflammation, suggesting a potential role for anti-inflammatory agents. ASPREE-D is a sub-study of ASPREE, a large multi-centre, population-based, double-blind, placebo-controlled trial of aspirin vs placebo in older Australian and American adults (median follow-up: 4.7 years) of whom 1,879 were depressed at baseline. Participants were given 100mg daily dose of aspirin or placebo. Depressive symptoms were assessed annually using the validated, self-rated short version of the Center for Epidemiological Studies Depression (CES-D-10) scale. There was a significant increase in depressive scores (0.6; 95% CI 0.2 to 0.9; Chi-square ( 1 ) = 10.37 ; p = 0.001) and a decreased score in the mental health component of a quality of life scale (−0.7; 95% CI −1.4 to −0.1; Chi-square ( 1 ) =4.74; p = 0.029) in the aspirin group compared to the placebo group. These effects were greater in the first year of follow-up and persisted throughout the study, albeit with small to very small effect sizes. This study failed to demonstrate any benefit of aspirin in the long-term course of depression in this community-dwelling sample of older adults over a 5-year period, and identified an adverse effect of aspirin in the course of depression in those with pre-existing depressive symptoms.

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“…Individuals with mood disorders have been shown to have altered membrane fatty acid composition; in this context, societies with high consumption of fish, which is high in ω-3 PUFAs, appear to have a lower prevalence of major depressive disorders [101]. In addition, new findings suggest that AA status influences depression pathophysiology via effects on serotonin transport [102]. It has been reported that fish oil supplementation in male mice with diet-induced obesity suppresses anxio-depressive behaviors, improves the brain's anti-inflammatory PUFA lipids, and reduces indices of brain gliosis [98].…”

Section: Discussionmentioning

confidence: 99%

DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring

et al. 2021

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We investigated if supplementing obese mothers (MO) with docosahexaenoic acid (DHA) improves milk long-chain polyunsaturated fatty acid (LCPUFA) composition and offspring anxiety behavior. From weaning throughout pregnancy and lactation, female Wistar rats ate chow (C) or a high-fat diet (MO). One month before mating and through lactation, half the mothers received 400 mg DHA kg−1 d−1 orally (C+DHA or MO+DHA). Offspring ate C after weaning. Maternal weight, total body fat, milk hormones, and milk nutrient composition were determined. Pups’ milk nutrient intake was evaluated, and behavioral anxiety tests were conducted. MO exhibited increased weight and total fat, and higher milk corticosterone, leptin, linoleic, and arachidonic acid (AA) concentrations, and less DHA content. MO male and female offspring had higher ω-6/ ω-3 milk consumption ratios. In the elevated plus maze, female but not male MO offspring exhibited more anxiety. MO+DHA mothers exhibited lower weight, total fat, milk leptin, and AA concentrations, and enhanced milk DHA. MO+DHA offspring had a lower ω-6/ω-3 milk intake ratio and reduced anxiety vs. MO. DHA content was greater in C+DHA milk vs. C. Supplementing MO mothers with DHA improves milk composition, especially LCPUFA content and ω-6/ω-3 ratio reducing offspring anxiety in a sex-dependent manner.

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Brain serotonin transporter binding, plasma arachidonic acid and depression severity: A positron emission tomography study of major depression

Cited by 28 publications

References 89 publications

The antidepressant effects and serum metabonomics of bifid triple viable capsule in a rat model of chronic unpredictable mild stress

The antidepressant effects and serum metabonomics of bifid triple viable capsule in a rat model of chronic unpredictable mild stress

Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial

DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring

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