"Brain Screen"

Giladi, Nir; Mordechovich, M.; Gruendlinger, Leor; Shabtai, H.; Merims, Doron; Naor, Simona; Baltadzhieva, R.; Hausdorff, Jeffrey M.; Gur, Alexander Y.; Bornstein, Natan M.

doi:10.1007/s00415-005-0986-6

Cited by 9 publications

(3 citation statements)

References 44 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In older adults, complaints about memory are associated with a wide array of mental health and physical disturbances, including impaired EF, depression, and frailty 36,37 . Memory, EF, TUG times, average gait speed, and stride time variability were normal or slightly worse than in “healthy” older adults 15,17,30,36 . Thus, the participants can be described as generally healthy, functionally independent, community‐living older adults with normal to mild decline in cognitive function and mobility.…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, self‐confidence regarding balance tended to be slightly below normal, 29 and all subjects complained about their memory. In older adults, complaints about memory are associated with a wide array of mental health and physical disturbances, including impaired EF, depression, and frailty 36,37 . Memory, EF, TUG times, average gait speed, and stride time variability were normal or slightly worse than in “healthy” older adults 15,17,30,36 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Can Methylphenidate Reduce Fall Risk in Community‐Living Older Adults? A Double‐Blind, Single‐Dose Cross‐Over Study

Ben-Itzhak

Giladi

Gruendlinger

et al. 2008

J American Geriatrics Society

View full text Add to dashboard Cite

Objectives-Among older adults, falls are a major health concern. A decrease in executive function (EF), common with aging, has been associated with gait instability, reduced mobility and other markers of fall risk. It is not known, however, whether augmenting EF affects gait and fall risk. We tested the hypothesis that methylphenidate modifies markers of fall risk in older adults.Design-Randomized, double-blind, placebo-controlled, single dose crossover study Author Contributions: Indicate authors' role in study concept and design, acquisition of subjects and/or data, analysis and interpretation of data, and preparation of manuscript. (See section on "Authorship and Duplicate Publication").RBY contributed to the study design, data collection, interpretation of the results, and wrote the first draft of the manuscript. NG contributed to the study design, data collection, interpretation of the results and revisions of the manuscript. LG contributed to data analysis, interpretation of the results, and revisions of the manuscript. JMH contributed to the study design, data collection, interpretation of the results, and revisions of the manuscript. All authors have seen and approved of the final version of the manuscript.Sponsor's Role: Indicate sponsor's role in the design, methods, subject recruitment, data collections, analysis and preparation of paper. Conflict of Interest Disclosures:Below is a checklist for all authors to complete and attach to their papers during submission. Setting-Outpatient movement disorders clinic. Elements of Financial/Personal ConflictsParticipants-Twenty-six non-demented, community-living older adults (mean age: 73.8 years) with subjective complaints of "memory problems."Interventions-The study examined the effects of a single dose of 20 mg of methylphenidate (MPH) on cognitive function and gait. Participants were evaluated before and two hours after taking MPH or a placebo in sessions separated by 1-2 weeks.Measurements-The Timed Up and Go and gait variability quantified mobility and fall risk. A computerized neuropsychology battery quantified memory and EF.Results-Compared to baseline, Timed Up and Go times, stride time variability, and measures of EF significantly improved in response to MPH, but not in response to the placebo. In contrast, memory and finger tapping abilities were not significantly affected by MPH.Conclusions-In older adults, MPH appears to improve certain aspects of EF, mobility and gait stability. Although additional studies are required to assess clinical utility and efficacy, the present findings suggest that methylphenidate and other drugs that are designed to enhance attention may have a role as a therapeutic option for reducing fall risk in older adults.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Can Methylphenidate Reduce Fall Risk in Community‐Living Older Adults? A Double‐Blind, Single‐Dose Cross‐Over Study

Ben-Itzhak

Giladi

Gruendlinger

et al. 2008

J American Geriatrics Society

View full text Add to dashboard Cite

show abstract

“…Scores for these cognitive indices were on an IQ-like scale, with 100 representing the average score in cognitively intact individuals, normalized for age and education. A global cognitive score based on the average across the memory, executive function, attention, and motor skills measures was also determined using this battery [ 62 – 64 ]. These tests were previously used to assess cognitive function in patients with PD in cross-sectional studies [ 16 , 36 , 53 , 65 – 67 ] and have also been responsive to interventions in PD [ 51 , 53 ].…”

Section: Methodsmentioning

confidence: 99%

Association between Community Ambulation Walking Patterns and Cognitive Function in Patients with Parkinson’s Disease: Further Insights into Motor-Cognitive Links

Weiss

Herman

Giladi

et al. 2015

Parkinson's Disease

View full text Add to dashboard Cite

Background. Cognitive function is generally evaluated based on testing in the clinic, but this may not always reflect real-life function. We tested whether parameters derived from long-term, continuous monitoring of gait are associated with cognitive function in patients with Parkinson's disease (PD). Methods. 107 patients with PD (age: 64.9 ± 9.3 yrs; UPDRS motor sum “off”: 40.4 ± 13.2; 25.23% women) wore a 3D accelerometer on their lower back for 3 days. Computerized measures of global cognitive function, executive function, attention, and nonverbal memory were assessed. Three-day acceleration derived measures included cadence, variability, bilateral coordination, and dynamic postural control. Associations between the acceleration derived measures and cognitive function were determined. Results. Linear regression showed associations between vertical gait variability and cadence and between global cognitive score, attention, and executive function (p ≤ 0.048). Dynamic postural control was associated with global cognitive score and attention (p ≤ 0.027). Nonverbal memory was not associated with the acceleration-derived measures. Conclusions. These findings suggest that metrics derived from a 3-day worn body-fixed sensor reflect cognitive function, further supporting the idea that the gait pattern may be altered as cognition declines and that gait provides a window into cognitive function in patients with PD.

show abstract

Current awareness in geriatric psychiatry

2006

Int J Geriat Psychiatry

View full text Add to dashboard Cite

In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of geriatric psychiatry. Each bibliography is divided into 9 sections: 1 Books, Reviews & Symposia; 2 General; 3 Assessment; 4 Epidemiology; 5 Therapy; 6 Care; 7 Dementia; 8 Depression; 9 Psychology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

show abstract

"Brain Screen"

Abstract: Screening self-referred adults for falls, strokes and dementia risk factors detected significant unknown risk factors that can be treated in more than one-third of the participants. A national "Brain Screen" program can have significant impact on the health of the aging population.

Cited by 9 publications

References 44 publications

Can Methylphenidate Reduce Fall Risk in Community‐Living Older Adults? A Double‐Blind, Single‐Dose Cross‐Over Study

Can Methylphenidate Reduce Fall Risk in Community‐Living Older Adults? A Double‐Blind, Single‐Dose Cross‐Over Study

Association between Community Ambulation Walking Patterns and Cognitive Function in Patients with Parkinson’s Disease: Further Insights into Motor-Cognitive Links

Current awareness in geriatric psychiatry

Contact Info

Product

Resources

About