Brain Responsivity to Emotional Faces Differs in Alcoholic Men and Women

Oscar‐Berman, Marlene; Ruiz, Susan Mosher; Marinković, Ksenija; Valmas, Mary M.; Harris, Gordon J.; Sawyer, Kayle S.

doi:10.1101/496166

Cited by 3 publications

(2 citation statements)

References 71 publications

(72 reference statements)

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“…Using software that provides automatic segmentation of hippocampal subfield volumes [6], three studies of abnormalities in AUD have reported smaller volumes of the subiculum, presubiculum, CA1, CA2+3, and CA4, or other parts of the hippocampus including dentate gyrus, hippocampal-amygdaloid transition area (HATA), and the fimbria [19][20][21]. In addition to brain abnormalities associated with AUD, interactions with age and gender have been revealed [22][23][24][25][26][27][28][29][30][31][32]. While the influence of age has been exemplified by a significant interaction of reduced volume of the CA2+3 region [19], hippocampal subfield projects in which women were included did not examine gender interactions [19,21].…”

Section: Introductionmentioning

confidence: 99%

Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder

et al. 2020

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Alcohol Use Disorder (AUD) has been associated with abnormalities in hippocampal volumes, but these relationships have not been fully explored with respect to sub-regional volumes, nor in association with individual characteristics such as age, gender differences, drinking history, and memory. The present study examined the impact of those variables in relation to hippocampal subfield volumes in abstinent men and women with a history of AUD. Using Magnetic Resonance Imaging at 3 Tesla, we obtained brain images from 67 participants with AUD (31 women) and 64 nonalcoholic control (NC) participants (31 women). The average duration of the most recent period of sobriety for AUD participants was 7.1 years. We used Freesurfer 6.0 to segment the hippocampus into 12 regions. These were imputed into statistical models to examine the relationships of brain volume with AUD group, age, gender, memory, and drinking history. Interactions with gender and age were of particular interest. Compared to the NC group, the AUD group had approximately 5% smaller subiculum, CA1, molecular layer, and hippocampal tail regions. Age was negatively associated with volumes for the AUD group in the subiculum and the hippocampal tail, but no significant interactions with gender were identified. The relationships for delayed and immediate memory with hippocampal tail volume differed for AUD and NC groups: Higher scores on tests of immediate and delayed memory were associated with smaller volumes in the AUD group, but larger volumes in the NC group. Length of sobriety was associated with decreasing CA1 volume in women (0.19% per year) and increasing volume size in men (0.38% per year). The course of abstinence on CA1 volume differed for men and women, and the differential relationships of subfield volumes to age and memory could indicate a distinction in the impact of AUD on functions of the hippocampal tail. These findings confirm and extend evidence that AUD, age, gender, memory, and abstinence differentially impact volumes of component parts of the hippocampus.

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Section: Introductionmentioning

confidence: 99%

Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder

et al. 2020

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“…Although results of MRI studies have suggested gender-specific susceptibility of the brain to alcohol abuse [6][7][8][9][10][11][12][13][14][15] , few studies have examined gender differences in the relationship between hippocampal volume and AUD. Instead, researchers have assessed AUD-related hippocampal abnormalities in men [16][17][18][19][20] , or in AUD groups comprised of a combination of men and women [21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Hippocampal Subfield Volumes in Abstinent Men and Women with a History of Alcohol Use Disorder

Sawyer

Salz

Adra

et al. 2019

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Alcohol use disorder (AUD) has been associated with abnormalities in hippocampal volumes, but these relationships have not been fully explored with respect to sub-regional volumes, nor in association with individual characteristics such as gender differences, age, and memory. The present study examined the impact of those variables in relation to hippocampal subfield volumes in abstinent men and women with a history of AUD. Using Magnetic Resonance Imaging at 3 Tesla, we obtained brain images from 67 participants (31 women) with AUD and 63 healthy control (NC) participants (30 women) without AUD. We used Freesurfer 6.0 to segment the hippocampus into 12 regions. These were imputed into mixed models to examine the relationships of brain volume with AUD group, gender, age, drinking history, and memory.The AUD group had approximately 5% smaller CA1, hippocampal tail, and molecular layer regions than the NC group. Age was negatively associated with volumes for the AUD group in the hippocampal tail, subiculum, and presubiculum. The relationships for delayed and immediate memory with hippocampal tail volume differed for AUD and NC groups: Higher scores were associated with smaller volumes in the AUD group, but larger volumes in the NC group. Length of sobriety was associated with decreasing CA1 volume in women (0.02% per year) and increasing volume size in men (0.03% per year). These findings confirm and extend evidence that AUD, gender, age, and abstinence differentially impact volumes of component parts of the hippocampus. The course of abstinence on CA1 volume differed for men and women, and the differential relationships of subregional volumes to age and memory could indicate a distinction in the impact of AUD on functions of the hippocampal tail.

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Alcohol Cues Elicit Different Abnormalities in Brain Networks of Abstinent Men and Women with Alcohol Use Disorders

Sawyer

Oscar‐Berman

et al. 2021

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We employed fMRI in 84 men and women with and without a history of alcohol use disorders (ALC and NC, respectively), to explore how gender interacts with alcoholism as reflected in brain activity elicited by alcohol cues. Brain activation was measured in a working memory task (delayed matching-to-sample) with emotional faces as the sample and match cues. During the delay period, intervening distractors were either reward-salient cues (alcoholic beverages) or neutral cues (nonalcoholic beverages or scrambled pictures). ALC women (ALCw) had higher accuracy than ALC men (ALCm). Analyses of scans during the viewing of distractor images revealed significant group-by-gender interactions. Compared to NC men, ALCm evidenced lower activation contrast between reward-salient cues and neutral cues in default mode network regions (including superior prefrontal and precuneus areas), while ALCw had more activation than NC women. Similar interactions were observed for task-regions (including superior parietal, lateral occipital, and prefrontal areas). Region of interest analyses showed that the ALC group had significantly higher levels of activation throughout reward-related circuitry during alcohol distractor interference than during scrambled picture interference. These results suggest that abstinent ALCm and ALCw differ in processing reward-salient cues, which can impact treatment and recovery.

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Brain Responsivity to Emotional Faces Differs in Alcoholic Men and Women

Cited by 3 publications

References 71 publications

Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder

Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder

Hippocampal Subfield Volumes in Abstinent Men and Women with a History of Alcohol Use Disorder

Alcohol Cues Elicit Different Abnormalities in Brain Networks of Abstinent Men and Women with Alcohol Use Disorders

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