Brain response in allergic rhinitis: Profile and proposal

Wang, Yao; Song, Xiao‐Yu; Wei, Shi‐Zhuang; Wang, Hanrui; Zhang, Wen‐Bin; Li, Yu-Mei; Mou, Yakui; Ren, Chao; Song, Xicheng

doi:10.1002/jnr.25159

Cited by 6 publications

(5 citation statements)

References 97 publications

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“…110 AR alters the functionality of the olfactory bulb (probably due to a constant neuro-inflammation), with cognitive impairment and "loss of energy" compared to active physical activity. [111][112][113] Further studies are necessary.…”

Section: Dovepressmentioning

confidence: 99%

Motor Dysfunctions in Fibromyalgia Patients: The Importance of Breathing

Bordoni,

Escher

2024

OARRR

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The classification of fibromyalgia (FM) is not always immediate and simple, with the time from the first diagnosis, compared to the onset of symptoms, of a few years. Currently, we do not have instrumental or biochemical tests considered as gold standards; the clinician will make a diagnosis of FM based on the patient’s medical history and subjective assessment. The symptoms can involve physical, cognitive and psychological disorders, with the presence of pain of different origins and classifications: nociplastic, nociceptive and neuropathic pain. Among the symptoms highlighted, postural disorders and neuromotor uncoordination emerge, whose functional dysfunctions can increase the mortality and morbidity rate. An alteration of the diaphragm muscle could generate such functional motor problems. Considering that the current literature underestimates the importance of breathing in FM, the article aims to highlight the relationship between motor and diaphragmatic difficulties in the patient, soliciting new points of view for the clinical and therapeutic framework.

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Section: Dovepressmentioning

confidence: 99%

Motor Dysfunctions in Fibromyalgia Patients: The Importance of Breathing

Bordoni,

Escher

2024

OARRR

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“…It usually shows symptoms such as stuffy nose, runny nose, sneezing and itchy nose 5 . These symptoms significantly impact the quality of life for affected individuals, imposing a substantial burden on both their families and society at large 6 . Research suggests that allergic diseases (asthma, AR, and AD) coexist to a certain extent due to the presence of numerous shared genetic risk variants.…”

Section: Introductionmentioning

confidence: 99%

“… 5 These symptoms significantly impact the quality of life for affected individuals, imposing a substantial burden on both their families and society at large. 6 Research suggests that allergic diseases (asthma, AR, and AD) coexist to a certain extent due to the presence of numerous shared genetic risk variants. These variants contribute to alterations in the expression of immune‐related genes.…”

Section: Introductionmentioning

confidence: 99%

Identification of potential drug targets for allergic diseases from a genetic perspective: A mendelian randomization study

Wang,

Pang,

Zhou

et al. 2024

Clinical & Translational All

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BackgroundAllergic diseases typically refer to a heterogeneous group of conditions primarily caused by the activation of mast cells or eosinophils, including atopic dermatitis (AD), allergic rhinitis (AR), and asthma. Asthma, AR, and AD collectively affect approximately one‐fifth of the global population, imposing a significant economic burden on society. Despite the availability of drugs to treat allergic diseases, they have been shown to be insufficient in controlling relapses and halting disease progression. Therefore, new drug targets are needed to prevent the onset of allergic diseases.MethodWe employed a Mendelian randomization approach to identify potential drug targets for the treatment of allergic diseases. Leveraging 1798 genetic instruments for 1537 plasma proteins from the latest reported Genome‐Wide Association Studies (GWAS), we analyzed the GWAS summary statistics of Ferreira MA et al. (nCase = 180,129, nControl = 180,709) using the Mendelian randomization method. Furthermore, we validated our findings in the GWAS data from the FinnGen and UK Biobank cohorts. Subsequently, we conducted sensitivity tests through reverse causal analysis, Bayesian colocalization analysis, and phenotype scanning. Additionally, we performed protein‐protein interaction analysis to determine the interaction between causal proteins. Finally, based on the potential protein targets, we conducted molecular docking to identify potential drugs for the treatment of allergic diseases.ResultsAt Bonferroni significance (p < 3.25 × 10−5), the Mendelian randomization analysis revealed 11 significantly associated protein‐allergic disease pairs. Among these, the increased levels of TNFAIP3, ERBB3, TLR1, and IL1RL2 proteins were associated with a reduced risk of allergic diseases, with corresponding odds ratios of 0.82 (0.76–0.88), 0.74 (0.66–0.82), 0.49 (0.45–0.55), and 0.81 (0.75–0.87), respectively. Conversely, increased levels of IL6R, IL1R1, ITPKA, IL1RL1, KYNU, LAYN, and LRP11 proteins were linked to an elevated risk of allergic diseases, with corresponding odds ratios of 1.04 (1.03–1.05), 1.25 (1.18–1.34), 1.48 (1.25–1.75), 1.14 (1.11–1.18), 1.09 (1.05–1.12), 1.96 (1.56–2.47), and 1.05 (1.03–1.07), respectively. Bayesian colocalization analysis suggested that LAYN (coloc.abf‐PPH4 = 0.819) and TNFAIP3 (coloc.abf‐PPH4 = 0.930) share the same variant associated with allergic diseases.ConclusionsOur study demonstrates a causal association between the expression levels of TNFAIP3 and LAYN and the risk of allergic diseases, suggesting them as potential drug targets for these conditions, warranting further clinical investigation.

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“…Nasal symptoms, including nasal congestion, itchy nose, rhinorrhea (runny nose), and sneezing, are the signature symptoms of AR, and symptoms last or accumulate for more than 1 h per day [ 7 ]. This long-term chronic nasal symptom may further lead to the decline of brain function, affect the quality of life of patients, reduce the efficiency of work and study in adults and children, and also lead to the patient’s irritability, and even cause anxiety, depression, and other neuropsychiatric symptoms [ 8 ]. It is estimated that about 40% of AR patients will be accompanied by bronchial asthma, and about 30–71% of AR patients will have allergic conjunctivitis or conjunctival symptoms [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence

Xu,

Liu,

et al. 2023

Clinic Rev Allerg Immunol

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Many potential environmental risk factors, protective factors, and biomarkers of AR have been published, but so far, the strength and consistency of their evidence are unclear. We conducted a comprehensive review of environmental risk, protective factors, and biomarkers for AR to establish the evidence hierarchy. We systematically searched Embase, PubMed, Cochrane Library, and Web of Science electronic database from inception to December 31, 2022. We calculated summary effect estimate (odds ratio (OR), relative risk (RR), hazard ratio (HR), and standardized mean difference (SMD)), 95% confidence interval, random effects p value, I2 statistic, 95% prediction interval, small study effects, and excess significance biases, and stratification of the level of evidence. Methodological quality was assessed by AMSTAR 2 (A Measurement Tool to Assess Systematic Reviews 2). We retrieved 4478 articles, of which 43 met the inclusion criteria. The 43 eligible articles identified 31 potential environmental risk factors (10,806,206 total population, two study not reported), 11 potential environmental protective factors (823,883 total population), and 34 potential biomarkers (158,716 total population) for meta-analyses. The credibility of evidence was convincing (class I) for tic disorders (OR = 2.89, 95% CI 2.11–3.95); and highly suggestive (class II) for early-life antibiotic use (OR = 3.73, 95% CI 3.06–4.55), exposure to indoor dampness (OR = 1.49, 95% CI 1.27–1.75), acetaminophen exposure (OR = 1.54, 95% CI 1.41–1.69), childhood acid suppressant use (OR = 1.40, 95% CI 1.23–1.59), exposure to indoor mold (OR = 1.66, 95% CI 1.26–2.18), coronavirus disease 2019 (OR = 0.11, 95% CI 0.06–0.22), and prolonged breastfeeding (OR = 0.72, 95% CI 0.65–0.79). This study is registered in PROSPERO (CRD42022384320).

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Brain response in allergic rhinitis: Profile and proposal

Cited by 6 publications

References 97 publications

Motor Dysfunctions in Fibromyalgia Patients: The Importance of Breathing

Motor Dysfunctions in Fibromyalgia Patients: The Importance of Breathing

Identification of potential drug targets for allergic diseases from a genetic perspective: A mendelian randomization study

Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence

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