Brain reserve and timing of clinical onset in multiple sclerosis
Maria Petracca,
Serena Ruggieri,
Riccardo Nistri
et al.
Abstract:Background: A latent period of variable length elapses between multiple sclerosis (MS) biological onset and the occurrence of the first clinical episode reflecting a central nervous system (CNS) demyelinating event. Factors affecting the duration of such interval are unknown. Objective: To explore whether brain reserve, which moderates the impact of structural damage along MS course, could also affect the timing of MS clinical onset. Methods: We conducted a time-to-event analysis in 326 relapsing-onset multipl… Show more
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