2010
DOI: 10.1016/j.biopsych.2009.12.034
|View full text |Cite
|
Sign up to set email alerts
|

Brain Reactivity to Smoking Cues Prior to Smoking Cessation Predicts Ability to Maintain Tobacco Abstinence

Abstract: Background Developing means to identify smokers at high risk for relapse could advance relapse prevention therapy. We hypothesized that functional magnetic resonance imaging (fMRI) reactivity to smoking-related cues, measured prior to a quit attempt, could identify smokers with heightened relapse vulnerability. Methods Twenty-one nicotine-dependent women underwent fMRI prior to quitting smoking, during which smoking-related and neutral images were shown. These smokers also were tested for possible attentiona… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

36
394
5
1

Year Published

2011
2011
2015
2015

Publication Types

Select...
5
4
1

Relationship

0
10

Authors

Journals

citations
Cited by 380 publications
(439 citation statements)
references
References 50 publications
36
394
5
1
Order By: Relevance
“…In both left and right INS, PSEs resulted in less deactivation than PNEs, an effect that was not observed for standard environments and proximal cues. The INS has been proposed as a critical substrate of tobacco use: smokers with insula damage exhibit increased likelihood of quitting smoking Naqvi et al, 2007); selfreported craving (Kuhn and Gallinat, 2011;Tang et al, 2012) and cessation outcomes (Janes et al, 2010) are correlated with insula reactivity to proximal smoking cues; and inactivation of insula decreases proximal cue-provoked nicotine seeking in rodents (Forget et al, 2010;Pushparaj et al, 2013). Less is known about the role of the insula in contextual drug effects; however, in a recent study, insula inactivation in rats led to disruption of amphetamine CPP (Contreras et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…In both left and right INS, PSEs resulted in less deactivation than PNEs, an effect that was not observed for standard environments and proximal cues. The INS has been proposed as a critical substrate of tobacco use: smokers with insula damage exhibit increased likelihood of quitting smoking Naqvi et al, 2007); selfreported craving (Kuhn and Gallinat, 2011;Tang et al, 2012) and cessation outcomes (Janes et al, 2010) are correlated with insula reactivity to proximal smoking cues; and inactivation of insula decreases proximal cue-provoked nicotine seeking in rodents (Forget et al, 2010;Pushparaj et al, 2013). Less is known about the role of the insula in contextual drug effects; however, in a recent study, insula inactivation in rats led to disruption of amphetamine CPP (Contreras et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…The ventral anterior putamen not only is larger in occasional stimulant users (Mackey et al, 2014), but this striatal subregion receives projections from the insula (Chikama et al, 1997), a brain region implicated in maintaining nicotine dependence (Naqvi et al, 2007) and smoking cue-reactivity (Janes et al, 2010). The insula and striatum may interact to mediate nicotine dependence, as damage to both of these brain regions disrupts smoking (Gaznick et al, 2014), and suggests a possible link between ventral anterior putamen deformations and cue-reactivity due to striatal-insula interactions.…”
Section: Discussionmentioning
confidence: 99%
“…Accordingly, the reactivity of this brain region has been suggested to serve as a biomarker to help predict relapse (Janes et al 2010).…”
Section: Involvement Of Interoceptive Circuitrymentioning
confidence: 99%