Brain Reactions Caused by Administration of Antigen

Perekrest, S V; Новикова, Н. С.; Корнева, Е. А.

doi:10.3233/nib-2011-003

Cited by 4 publications

(3 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LPS injection has been shown to cause degeneration of orexinergic neurons [44,45]. It is therefore possible that the state instability observed in sepsis models (Baracchi et al, 2011, this paper) is in part related to the loss of these neurons [46,47].…”

Section: Discussionmentioning

confidence: 99%

Sepsis-Induced Brain State Instability

Kala

Leemburg

Ježek

2022

Preprint

View full text Add to dashboard Cite

Background Sepsis-associated brain dysfunction (SABD) is a frequent severe complication of sepsis and the systemic inflammatory response syndrome. It is associated with high mortality and a majority of survivors suffer long-term neurological consequences. Sleep is commonly affected in sepsis and there is a strong correlation between its impairment and development of other complications or increased mortality in sepsis patients. Here, we investigate the effects of sepsis on brain activity patterns in order to better understand possible sources of sleep-wake disturbances associated with severe systemic inflammation. Methods We studied the effects of high LPS doses (10mg/kg) on oscillatory brain states in an acute rat model of sepsis under urethane anaesthesia, which maintains REM- and NREM sleep-like states. Twelve Long-Evans rats (6 LPS, 6 controls) were implanted with eight independently movable tetrodes in the dorsal hippocampus. Baseline LFP activity was recorded for 3 hours after saline injection, followed by another 3 hours after LPS or saline injection. REM and NREM were automatically classified based on LFP activity and quantified. Within- and between-state dynamics were analysed using a 2-D state space approach based on spectral power ratios. Aperiodic and periodic components of the power spectrum were quantified for each state. Blood serum samples and brains were collected for IL-1β quantification and histological verification of electrode placement. Results Soon after LPS injection we observed a robust fragmentation of both oscillatory states resulting in a three-fold increase in the number of state transitions that lasted for several hours, although the overall time spent in either state did not change. Analysis of power spectra showed opposing shifts in low frequency oscillations (1–9 Hz) in REM and NREM that resulted in increased similarity between both states in 2-D state space. Conclusions The observed increased spectral similarity between REM and NREM and increased instability within the states may point to a mechanism underlying the severe sleep fragmentation described both in sepsis patients and in SABD animal models.

show abstract

Section: Discussionmentioning

confidence: 99%

Sepsis-Induced Brain State Instability

Kala

Leemburg

Ježek

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Additionally, cytokine signaling plays an important role in regulating sleep pressureunder normal circumstances (Opp, 2005). LPS injection has been shown to cause degeneration of orexinergic neurons (Perekrest et al, 2011(Perekrest et al, , 2008. It is therefore possible that the state instability observed in sepsis models (Baracchi et al, 2011;this paper) is in part related to the loss of these neurons (Fronczek et al, 2021;Zeitzer et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Sepsis-induced brain state instability

Kala

Leemburg

Jezek

2022

Preprint

View full text Add to dashboard Cite

Sepsis-associated brain dysfunction (SABD) is a frequent severe complication of sepsis and the systemic inflammatory response syndrome. It is associated with high mortality and a majority of survivors suffer long-term neurological consequences. Here, we studied the effects of SABD on oscillatory brain states in an acute rat model of sepsis induced by high dose LPS (10 mg/kg). To focus on intrinsically generated brain state dynamics, we used a urethane model that spares oscillatory activity in REM- and NREM-like sleep states. Soon after the intraperitoneal LPS injection we observed a robust fragmentation of both oscillatory states resulting in a three-fold increase in the number of state transitions that lasted for several hours, although the overall time spent in either state did not change. Analysis of power spectra showed opposing shifts in low frequency oscillations (1-9 Hz) that resulted in increased similarity between both states in 2-D state space. The described spectral characteristics of sepsis-induced EEG state instability might point to a mechanism underlying severe sleep fragmentation as described both in sepsis patients and in SABD animal models.

show abstract

“…Noradrenergic, cholinergic, serotonergic, dopaminergic and neuropetide Y containing neurons, vasopressin neurons, histaminergic neurons and orexinergic neurons are all involved in the brain response to antigenic stimulation. Although much remains to be established it is very clear that the brain is responding strongly to antigenic stimulation [55]. As a matter of fact, neurons express TLRs of innate immunity, so the brain may be considered to be an immunocompetent organ [4].…”

Section: Discussionmentioning

confidence: 99%

Introduction: Advances in Neuroimmune Biology: A Comprehensive way to Look at Biology

Berczi

Katafuchi

2011

Advances in Neuroimmune Biology

View full text Add to dashboard Cite

After a long period of specialization in science it has been gradually realized that the time has come for coordination, integration and interpretation in Biological Sciences. Advances in Neuroimmune Biology (ANIB) will fulfill, in part, this objective. ANIB deals with the immune-neuroendocrine circuitry as it integrates, coordinates and regulates all biological events in animals and men. This constitutes the Neuroimmune Super system (NISS), the ultimate central regulator of biological processes in animals. Homeostasis is discussed with respect to immune function. The role of the autonomic nervous system, immunological memory, Pavlovian conditioning of immunity, immune deficiency, stress, mast cells and neuroinflammation are included. Therapeutical application of the new knowledge is also considered.

show abstract

Brain Reactions Caused by Administration of Antigen

Cited by 4 publications

References 97 publications

Sepsis-Induced Brain State Instability

Sepsis-Induced Brain State Instability

Sepsis-induced brain state instability

Introduction: Advances in Neuroimmune Biology: A Comprehensive way to Look at Biology

Contact Info

Product

Resources

About