Brain proton magnetic resonance spectroscopy in children exposed to methamphetamine in utero

Smith, Lynne M.; Chang, Linda; Yonekura, Masahiro; Grob, Charles S.; Osborn, Diane; Ernst, Thomas

doi:10.1212/wnl.57.2.255

Cited by 104 publications

(74 citation statements)

References 35 publications

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“…In human users, magnetic resonance imaging has shown long-term changes in various brain regions, including the hippocampus, following MA exposure either in adulthood or during in utero development (Smith et al 2001;Chang et al 2004;Thompson et al 2004). In animal studies, we have shown that the dentate gyrus and nucleus accumbens have a reduction in dendritic spines in adulthood when the animals were exposed to MA as neonates (Williams et al 2004a).…”

Section: Discussionmentioning

confidence: 95%

Ontogeny of the adrenal response to (+)-methamphetamine in neonatal rats: The effect of prior drug exposure

Williams

Schaefer

Furay

et al. 2006

Stress

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We examined the ontogeny of the corticosterone response to (+)-methamphetamine in neonatal rats. In experiment-1, animals were injected with 10 mg/kg of (+)-methamphetamine or saline and plasma corticosterone levels were examined in separate groups 30 or 105 min later on postnatal day (P) 1, 3, 5, 7, 9, 11, 13, 15, 17, or 19. The adrenal response to methamphetamine was best described by a U-shaped function with the nadir of corticosterone release occurring between P7 and P13. Experiment-2 was similar except that the effect of four consecutive days of exposure to (+)-methamphetamine (four times daily at 2 h intervals with 10 mg/kg) was assessed with a single final dose early on the fifth day (i.e. P1-5, 3-7, 5-9, 7-11, 9-13, 11-15, 13-17, 15-19). The 30 min corticosterone response after multiple methamphetamine doses was augmented compared to single exposures, with the exception of the two earliest dosing intervals ending on P5 and P7, where the responses were lower. In addition, at 105 min, the levels of corticosterone were attenuated relative to a single drug administration. With the exception of animals receiving methamphetamine from P15 to P19, thymus weights were unaffected. The data demonstrate that (+)-methamphetamine is a robust activator of corticosterone release in developing animals and this release is extensively modified by age and previous drug exposure.

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Section: Discussionmentioning

confidence: 95%

Ontogeny of the adrenal response to (+)-methamphetamine in neonatal rats: The effect of prior drug exposure

Williams

Schaefer

Furay

et al. 2006

Stress

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“…Cranial ultrasound studies of human newborns exposed to prenatal MA and cocaine demonstrated an increased incidence of intraventricular hemorrhage and white matter densities [14]. In addition, a study of MA-exposed children aged 3-16 years employing magnetic resonance spectroscopy demonstrated increased concentrations of creatine in the striatum suggesting a possible abnormality in energy metabolism in the brains of exposed children [40]. Volumetric assessments of magnetic resonance images in exposed children have demonstrated smaller subcortical volumes including the putamen, globus pallidus and hippocampus [11].…”

Section: Discussionmentioning

confidence: 99%

Prenatal methamphetamine use and neonatal neurobehavioral outcome

Smith

LaGasse²,

Derauf

et al. 2008

Neurotoxicology and Teratology

164

127

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Background-Methamphetamine (MA) use among pregnant women is an increasing problem in the United States. How prenatal MA exposure affects neonatal neurobehavior is unknown.Objective-To examine the neurobehavioral effects of prenatal MA exposure.Design-The Infant Development, Environment and Lifestyle (IDEAL) study screened 13,808 subjects and 1632 were eligible and consented. 166 (n=74 exposed) were enrolled in a longitudinal follow up. Exposure was determined by meconium assay and self-report with alcohol, marijuana, and tobacco present in both groups. The NICU Network Neurobehavioral Scale (NNNS) was administered within the first 5 days of life. Analyses conducted on NNNS summary scores included exposure group effects, heavy MA use effects, association with frequency of use by trimester, and dose-response relationships with amphetamine metabolites.Results-After adjusting for covariates, exposure to MA was associated with increased physiological stress. Heavy MA use was related to lower arousal, more lethargy, and increased physiological stress. First trimester MA use was related to elevated physiological stress. Third trimester use was related to poorer quality of movement. Higher level of amphetamine metabolites in meconium was associated with increased CNS stress.Conclusions-Prenatal MA exposure was associated with neurobehavioral patterns of decreased arousal, increased stress, and poor quality of movement. The dose response relationships may represent neurotoxic effects from MA.

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“…A neuroimaging study of 26 methamphetamine exposed (prenatal) and non-methamphetamine exposed children (128) suggested an abnormality in energy metabolism (increased creatine in the striatum) in the brains of children prenatally exposed to methamphetamine. These changes were not found to be associated with any increase in reported behavioural changes in the children.…”

Section: Chronic Effectsmentioning

confidence: 99%

Exposures associated with clandestine methamphetamine drug laboratories in Australia

Wright

Edwards

Walker

2016

Reviews on Environmental Health

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AbstractThe clandestine manufacture of methamphetamine in residential homes may represent significant hazards and exposures not only to those involved in the manufacture of the drugs but also to others living in the home (including children), neighbours and first responders to the premises. These hazards are associated with the nature and improper storage and use of precursor chemicals, intermediate chemicals and wastes, gases and methamphetamine residues generated during manufacture and the drugs themselves. Many of these compounds are persistent and result in exposures inside a home not only during manufacture but after the laboratory has been seized or removed. Hence new occupants of buildings formerly used to manufacture methamphetamine may be unknowingly exposed to these hazards. Children are most susceptible to these hazards and evidence is available in the literature to indicate that these exposures may result in immediate and long-term adverse health effects. The assessment of exposure within the home can be undertaken by measuring contaminant levels or collecting appropriate biological data from individuals exposed. To gain a better understanding of the available data and key issues associated with these approaches to the characterisation of exposure, a review of the published literature has been undertaken.

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Brain proton magnetic resonance spectroscopy in children exposed to methamphetamine in utero

Abstract: The authors found increased [Cr] in the striatum with relatively normal [NA] in children exposed to methamphetamine. These findings suggest an abnormality in energy metabolism in the brains of children exposed to methamphetamine in utero.

Cited by 104 publications

References 35 publications

Ontogeny of the adrenal response to (+)-methamphetamine in neonatal rats: The effect of prior drug exposure

Ontogeny of the adrenal response to (+)-methamphetamine in neonatal rats: The effect of prior drug exposure

Prenatal methamphetamine use and neonatal neurobehavioral outcome

Exposures associated with clandestine methamphetamine drug laboratories in Australia

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