Brain processing of visual sexual stimuli in men with hypoactive sexual desire disorder*1

Stoléru, Serge; Redouté, Jérôme; Costes, Nicolas; Lávenne, F.; Bars, Didier Le; Déchaud, H.; Forest, Maguelone G.; Pugeat, Michel; Cinotti, L.; Pujol, J.F.

doi:10.1016/s0925-4927(03)00068-4

Cited by 119 publications

(81 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, PET scan studies have shown differences in brain activation among men with normal compared with hypoactive sexual responses when viewing sexual stimuli of varying grades of intensity. 3 In men with hypoactive sexual desire disorder, prolonged activation of the medial orbitofrontal cortex, which is involved in general inhibition of motivation, was seen.…”

Section: Neuroanatomy Of Male Sexual Responsementioning

confidence: 99%

Preclinical effects of melanocortins in male sexual dysfunction

Shadiack¹,

Althof²

2008

Int J Impot Res

View full text Add to dashboard Cite

The neurobiology of sexual behavior involves the interrelationships between sex steroids and neurotransmitters that result in both central nervous system (CNS) effects and effects in the genitalia. Tools such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) scanning can help determine what areas of the brain are activated under sexual stimulation. Our understanding of the role of various neurotransmitters, neurosteroids and other CNS-acting compounds is improving. The role of CNS-acting compounds such as dopamine agonists in the treatment of male sexual dysfunction is under active investigation. Melanocortins have CNS and peripheral roles in a wide variety of bodily functions. The melanocortin agonist bremelanotide appears to act in the CNS to promote erections in preclinical models, and may also stimulate behaviors that facilitate sexual activity beyond their erectogenic effects.

show abstract

Section: Neuroanatomy Of Male Sexual Responsementioning

confidence: 99%

Preclinical effects of melanocortins in male sexual dysfunction

Shadiack¹,

Althof²

2008

Int J Impot Res

View full text Add to dashboard Cite

show abstract

“…After stimulation, the brain releases stimulatory neurotransmitters (dopamine, nitric oxide, oxytocin, serotonin), from oxytoninergic, serotonergic, and dopaminergic neurons located in "erection centers" in the limbic system (paraventricular and supraoptic nuclei) that will generate proerectile impulses via the parasympathetic system [50][51][52][53]. Parasympathetic impulses stimulate the spinal parasympathetic reflexogenic erection centers located at level S2-S4 [50] that will directly induce the vascular changes in the cavernous bodies, dilatation of arterioles, increased blow flow, decreased venous outflow due to compression of the subtunical venular plexuses, increase in oxygen pressure raising the penis, with subsidiary contraction of the ischiocavernosus muscles.…”

Section: Erectionmentioning

confidence: 99%

Hypogonadism in Male Sexual Dysfunction

Stoian¹,

Mozoş²,

Craina³

et al. 2017

Sexual Dysfunction

View full text Add to dashboard Cite

Normal testosterone level is influencing all the steps of the male psychosexual development: intrauterine neonatal and final psychosexual development.. At pubertal stage, the quality of testosterone secretion is conditioning the development of the mature male phenotype. In adult life, eugonadism sustains desire, arousal, determines spontaneous erections, facilitates stimulated erection, influencing the response rate to medication. Moreover, eugonadism sustain daydreaming and phantasies, both needed for a normal sexual life. The pathogenic mechanism of all these actions is presented. Talking about hypogonadism means not only the classical types of hypogonadism: due to classical testicular disease of central, hypothalamic and hypophysis disease, but also the partial testosterone deficiency induces by aging (late onset hypogonadism), weight increase (up to 30% of males with metabolic syndrome and 50% of males with diabetes) or secondary hypogonadism described in chronic use of steroids or after long exposure to stress, especially in young males. All these types of hypogonadism, that affect young, middle aged or old males will be presented separately. A therapeutic approach that is individualized for each type of hypogonadism, should consider positive and possible negative effects and all alternatives will be presented: life style changes, sustained weight loss, increase exercise, supplemental therapy, pro fertility treatment.

show abstract

“…Ces etudes ont permis d'entamer une description precise des r6gions c6r6brales pr~sentant une activation ou une desactivation en r6ponse a la pr6sentation de stimuli sexuels visuels, ou encore de repr6sentation mentales de situations sexuellement excitantes. Plus r6cemment, I'imagerie fonctionnelle a et6 utilis~e pour ~tudier les correlats c6rebraux de certains troubles du comportement sexuel [36,49,68].…”

Section: Imagerie Fonctionnelle De La Motivation Sexuelleunclassified

“…Sur la base de nos r6sultats chez le sujet sain [56,67] et chez des patients souffrant de desir sexuel hypoactif [68], nous avons propos6 un module neurocomportemental des regions c6r6brales impliqu6es dans I'excitation sexuelle, ce modele comprenant des composantes cognitive, motivationnelle, ~motionnelle et v~g~tative. Pour chacune de ces composantes, un systeme de processus inhibiteurs a 6ga-lement et6 mis en 6vidence [68].…”

Section: Imagerie Fonctionnelle De La Motivation Sexuelleunclassified

Role of androgens in male sexual motivation: approach with functional brain imaging techniques

Redouté

Stoléru

2004

Androl.

View full text Add to dashboard Cite

I. I N T R O D U C T I O NLe syst~me nerveux central joue un r61e a toutes les etapes du comportement sexuel, notamment en ce qui concerne le traitement des stimuli externes [47]. Chez de nombreux mammif6res, comme par exempie chez le singe, certaines caracteristiques des femelies, determinees hormonalement, telles que des odeurs [11] ou des stimuli visuels [15], declanchent le comportement sexuel des m~les. Ceci n6cessite un traitement central de rensemble des informations sensorielles. Dans I'espece humaine, rattractivite sexuelle depend egalement d'un certains nombre de facteurs [20], et la pertinence des stimuli externes dolt en permanence ~tre analysee pour que la r6ponse sexuelle puisse se developper. En particulier, une etape cle consiste en I'attribution & ces signaux externes d'une valeur dite de << recompense )) qui conditionnera la raise en place des differentes etapes de rexcitation sexuelle [58]. Ces etapes font intervenir des processus cognitifs complexes [8], interagissant avec des composantes ~motionnelles et physiologiques.Nous verrons qu'au sein de cette composante physiologique, un interet particulier dolt etre porte au r61e joue par les androg~nes (et notamment la testosterone) dans la regulation et le maintien du comportement sexuel. Cette fonction regulatrice des androg~nes fait essentiellement intervenir leur action au sein du syst~me nerveux central. Ce r61e fondamental est en particulier mis en evidence dans le cadre de pathologies entraTnant un d6ficit andro-

show abstract

Brain processing of visual sexual stimuli in men with hypoactive sexual desire disorder*1

Cited by 119 publications

References 64 publications

Preclinical effects of melanocortins in male sexual dysfunction

Preclinical effects of melanocortins in male sexual dysfunction

Hypogonadism in Male Sexual Dysfunction

Role of androgens in male sexual motivation: approach with functional brain imaging techniques

Contact Info

Product

Resources

About