Brain Potentials and Morphine Addiction

Andrews, Howard L.

doi:10.1097/00005053-194303000-00036

Cited by 5 publications

(7 citation statements)

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“…Andrews (1941) noted marked behavioural effects in nonnal individuals: 'Nausea, even to the point of vomiting, lassitude and general depression were common experiences and there was Hewett & Martin (1980) Behaviour and subjective effects The behavioural effects of heroin are similar to those of morphine after subcutaneous (Fraser, Van Horn, Martin, Wolbach & Isbell, 1961) and intravenous administration in nondependent opiate addicts. Both produce a typical pattern of physiological signs (miosis, analgesia, bradypnea, hypothermia), behaviour (talkativeness, scratching, vomiting, nodding), and subjective effects (euphoria, 'coasting', internal energy, itchy, 'turning' of stomach).…”

Section: Discussionmentioning

confidence: 99%

“…Morphine also slows alpha frequency and produces slower frequencies in some humans at a 20 mg i.m. dosage (Andrews, 1941;1943 (Kay et al, 1969;Pickworth et al, 1981). Morphine (7.5, 15, 30 mg/70 kg) produces a dose-related increase in insomnia and muscle tension in nondependent opiate addicts (Kay et al, 1969); it also produces a doserelated decrease in REM sleep and delta sleep.…”

Section: Discussionmentioning

confidence: 99%

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Morphine‐like insomnia from heroin in nondependent human addicts.

Dc¹,

Pickworth²,

Neider³

1981

Brit J Clinical Pharma

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1 This study was performed because dose-related effects of heroin on human sleep had not been described previously, and to discover if heroin produces a morphine-like insomnia. 2 After three adaptation nights, the sleep of seven male nondependent opiate addicts was studied following i.m. doses of heroin (3, 6, 12 mg/70 kg), morphine (10, 20 mg/70 kg) or placebo at weekly intervals in a randomized double-blind crossover design. 3 Heroin produces a dose-related increase in wakefulness, drowsiness episodes, muscle tension, and shifts in sleep-waking states.I 4 Heroin produces a dose-related decrease in total sleep, sleep efficiency, delta sleep and REM sleep (REMS). 5 Heroin is about twice as potent as morphine in producing this type of insomnia. 6 'Morphine insomnia' appears to be a characteristic initial effect of several opioids, at least in nondependent opiate addicts, and might serve as a model insomnia for evaluation of hypnotics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Morphine‐like insomnia from heroin in nondependent human addicts.

Dc¹,

Pickworth²,

Neider³

1981

Brit J Clinical Pharma

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“…Opioid-induced slowing of the EEG in human sub jects was &rst discovered by visual observation of EEG tracings (Berger 1937;Andrews 1941Andrews , 1943Gibbs and Maltby 1943). Slowing has been de&ned in several ways.…”

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confidence: 99%

Morphine Effects on the Spontaneous Electroencephalogram in Polydrug Abusers: Correlations with Subjective Self-Reports

Phillips

Herning

London

1994

Neuropsychopharmacol

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The spontaneous electroencephalogram (EEG) was recorded after the intramuscular (IM) injection of morphine sulfate (15, 30 mg) or saline (0.9% NaCl). Correlations between changes in EEG spectral power and subjective self-reports, as measured on subscales of the Addiction Research Center Inventory (ARC!), were evaluated. Morphine increased alphaJ and alpha2 power and theta power, and attenuated the increase in delta power observed after placebo. Positive correlations were found between the change in alpha1, alpha2, beta1, and beta2 power in response to 30 mg of morphine and scores

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“…The pre-injection threshold is practically normal but the response following the drug is only a fraction of that obtained in non-addicts. It has been suggested (7) that the first addiction produces certain irreversible changes which might be thought of as residual tolerance. The present studies confirm this suggestion and indicate that the changes in the pain threshold mechanism are strongly irreversible.…”

Section: Discussionmentioning

confidence: 99%