Brain Perfusion Single Photon Emission Computed Tomography Findings in Patients with Posttraumatic Anosmia and Comparison with Radiological Imaging

Eftekhari, Mohammad; Assadi, Majid; Kazemi, Mohammad Hossein; Saghari, Mohsen; Mojtahedi, Alireza; Fard-Esfahani, Armagan; Sichani, Babak Fallahi; Beiki, Davood

doi:10.2500/ajr.2006.20.2906

Cited by 16 publications

(23 citation statements)

References 28 publications

(32 reference statements)

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“…These results suggest that olfactory dysfunction decreases cortical responses to trigeminal stimulation. A single-photon emission computed tomography (SPECT) study reported that blood flow abnormality in the frontal lobe (particularly, in the orbitofrontal regions) was commonly observed in the posttraumatic anosmic patients (Eftekhari et al 2006). These previous studies are consistent with the present results in that olfactory dysfunction decreased cortical activities in response to chemical substances.…”

Section: Effects Of Dysosmia On Hemodynamic Responsessupporting

confidence: 91%

Cortical Hemodynamic Responses to Intravenous Thiamine Propyldisulphide Administration Detected by Multichannel Near Infrared Spectroscopy (NIRS) System

et al. 2011

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Intravenous injection of thiamine propyldisulphide (TPD), which induces sensation of a garlic-like odor, has been used as a representative subjective olfactory test in Japan. However, cortical loci activated by TPD still remain unclear. We recorded cerebral hemodynamic responses (changes in Oxy-Hb concentrations) induced by TPD administration using whole-head multi-channel near infrared spectroscopy (NIRS) system based on 3D-MRIs. TPD as an odorant and saline as a control were injected from the cephalic vein in the left forearm in ten male normosmic (five young and five elderly) subjects and five dysosmic elderly patients. The all normosmic, but not dysosmic, subjects felt the garlic-like odor in the all TPD trials. There was no significant difference in hemodynamic responses between the young and elderly normosmic subjects. However, TPD injection induced significantly larger hemodynamic responses in the bilateral operculums, bilateral dorsolateral prefrontal cortices (PFC) and anteromedial PFC in the normosmic subjects, compared with saline injection. Onset latencies of these hemodynamic responses were significantly correlated with onset latencies of subjective odor sensation in the normosmic subjects. Comparison of hemodynamic responses between the normosmic and dysosmic subjects indicated a significant difference in the bilateral operculums. The results demonstrated that Oxy-Hb increases in the bilateral operculums reflected olfactory sensation induced by TPD injection. Consideration of a route for intravenous TPD to reach the olfactory mucosa suggests that these hemodynamic responses might be attributed to food-related retronasal olfactory responses to TPD.

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Section: Effects Of Dysosmia On Hemodynamic Responsessupporting

confidence: 91%

Cortical Hemodynamic Responses to Intravenous Thiamine Propyldisulphide Administration Detected by Multichannel Near Infrared Spectroscopy (NIRS) System

et al. 2011

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“…15 In another study conducted by Eftekhari et al , 78% of the posttraumatic anosmic patients had abnormal SPECT findings in their orbital and frontal regions. 14 This result was slightly lower than the one in our study, viz. , 82% MRI abnormality and 85% SPECT abnormality.…”

Section: Discussioncontrasting

confidence: 73%

“…Therefore, certain objective tests such as magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), positron emission tomography scan, and functional MRI have been proposed as imaging methods. 12–16…”

mentioning

confidence: 99%

Estimation of Sensitivity and Specificity of Brain Magnetic Resonance Imaging and Single Photon Emission Computed Tomography in the Diagnosis of Olfactory Dysfunction after Head Traumas

Atighechi

Zolfaghari

Baradaranfar

et al. 2013

Am J Rhinol�Allergy

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“…In addition, the aforementioned region was demonstrated on our prior studies that had an important role in status of olfactory. It may amend to do a follow up study in MS patients [ 33 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Brain perfusion imaging with voxel-based analysis in secondary progressive multiple sclerosis patients with a moderate to severe stage of disease: a boon for the workforce

et al. 2016

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BackgroundThe present study was carried out to evaluate cerebral perfusion in multiple sclerosis (MS) patients with a moderate to severe stage of disease. Some patients underwent hyperbaric oxygen therapy (HBOT) and brain perfusion between before and after that was compared.MethodsWe retrospectively reviewed 25 secondary progressive (SP)-MS patients from the hospital database. Neurological disability evaluated by Expanded Disability Status Scale Score (EDSS). Brain perfusion was performed by (99 m) Tc-labeled bicisate (ECD) brain SPECT and the data were compared using statistical parametric mapping (SPM). In total, 16 patients underwent HBOT. Before HBOT and at the end of 20 sessions of oxygen treatment, 99mTc-ECD brain perfusion single photon emission computed tomography (SPECT) was performed again then the results were evaluated and compared. Brain perfusion was performed by (99 m) Tc-labeled bicisate (ECD) brain SPECT and the data were compared using statistical parametric mapping (SPM).ResultsA total of 25 SP-MS patients, 14 females (56 %) and 11 males (44 %) with a mean age of 38.92 ± 11.28 years included in the study. The mean disease duration was 8.70 ± 5.30 years. Of the 25 patients, 2 (8 %) had a normal SPECT and 23 (92 %) had abnormal brain perfusion SPECT studies. The study showed a significant association between severity of perfusion impairment with disease duration and also with EDSS (P <0.05). There was a significant improvement in pre- and post-treatment perfusion scans (P <0.05), but this did not demonstrate a significant improvement in the clinical subjective and objective evaluation of patients (P >0.05).ConclusionsThis study depicted decreased cerebral perfusion in SP-MS patients with a moderate to severe disability score and its association with clinical parameters. Because of its accessibility, rather low price, practical ease, and being objective quantitative information, brain perfusion SPECT can be complementing to other diagnostic modalities such as MRI and clinical examinations in disease surveillance and monitoring. The literature on this important issue is extremely scarce, and follow up studies are required to assess these preliminary results.

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Brain Perfusion Single Photon Emission Computed Tomography Findings in Patients with Posttraumatic Anosmia and Comparison with Radiological Imaging

Cited by 16 publications

References 28 publications

Cortical Hemodynamic Responses to Intravenous Thiamine Propyldisulphide Administration Detected by Multichannel Near Infrared Spectroscopy (NIRS) System

Cortical Hemodynamic Responses to Intravenous Thiamine Propyldisulphide Administration Detected by Multichannel Near Infrared Spectroscopy (NIRS) System

Estimation of Sensitivity and Specificity of Brain Magnetic Resonance Imaging and Single Photon Emission Computed Tomography in the Diagnosis of Olfactory Dysfunction after Head Traumas

Brain perfusion imaging with voxel-based analysis in secondary progressive multiple sclerosis patients with a moderate to severe stage of disease: a boon for the workforce

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