2016
DOI: 10.1007/s11325-016-1435-8
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Brain pathway differences between Parkinson’s disease patients with and without REM sleep behavior disorder

Abstract: White matter alterations in the cingulum, IFOF regions, and corpus callosum might explain faster cognitive deterioration in PD patients with RBD, in terms of visual recognition and visuospatial dysfunction and executive function. Disturbed brain structural tissue markers in CST in PD + RBD patients, could be justified in the light of faster motor progression in these patients.

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Cited by 38 publications
(23 citation statements)
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“…Together, these results support our hypothesis of a unique cross-sectional association between pRBD and worse cognitive performance in nondemented PD patients, although the direction of this relationship remains unclear. These findings are consistent with previous studies associating RBD in PD with poorer verbal learning (Erro et al, 2012;Jozwiak et al, 2017;Vendette et al, 2007) and executive functioning (Jozwiak et al, 2017;Sinforiani et al, 2006;Vendette et al, 2007;Zhang et al, 2016) compared to HCs and/or PD patients without RBD, as well as imaging studies implicating abnormalities in frontal and temporal regions and microstructural pathways subserving these cognitive functions (Ansari, Rahmani, Dolatshahi, Pooyan, & Aarabi, 2017;Ford et al, 2013;Lim et al, 2016).…”
Section: Discussionsupporting
confidence: 92%
“…Together, these results support our hypothesis of a unique cross-sectional association between pRBD and worse cognitive performance in nondemented PD patients, although the direction of this relationship remains unclear. These findings are consistent with previous studies associating RBD in PD with poorer verbal learning (Erro et al, 2012;Jozwiak et al, 2017;Vendette et al, 2007) and executive functioning (Jozwiak et al, 2017;Sinforiani et al, 2006;Vendette et al, 2007;Zhang et al, 2016) compared to HCs and/or PD patients without RBD, as well as imaging studies implicating abnormalities in frontal and temporal regions and microstructural pathways subserving these cognitive functions (Ansari, Rahmani, Dolatshahi, Pooyan, & Aarabi, 2017;Ford et al, 2013;Lim et al, 2016).…”
Section: Discussionsupporting
confidence: 92%
“…Secondly, because the frequency of RBD increases as PD progresses , some patients with PD‐cpRBD− in this study might develop RBD later. Thirdly, in addition to motor decline, patients with PD‐cpRBD+ also show faster cognitive decline along with structural brain changes compared to those with PD‐cpRBD− . Therefore, MMSE scores might be lower in the PD‐cpRBD+ group than in the PD‐cpRBD− group at the time of RBDSQ assessment, although those at baseline were comparable between the two groups.…”
Section: Discussionmentioning
confidence: 99%
“…As indicated above, previously published studies has investigated connectometry differences in other neurological diseases [24][25][26][27][28][29][30][31][32][33][34], adopting SDF as biomarker of investigation. SDF is a densitybased measurement of diffusion at different orientations and it measures the density of diffusing water, differently from other diffusivity measurements such as Fractional Anisotropy (FA), Apparent Diffusion Coefficient (ADC) and Radial Diffusivity.…”
Section: Discussionmentioning
confidence: 99%
“…The spin distribution function (SDF) is the parameter used for the analysis [23]. This method has been already used for example for the study of Parkinson disease [24][25][26][27][28][29][30], mood disorders [31,32], multiple sclerosis [33] and amyotrophic lateral sclerosis [34].…”
Section: Introductionmentioning
confidence: 99%