Brain or gut? Site of action of adrenomedullin to regulate gut motility

Adrenomedullin regulates intestinal physiology and pathophysiology

“…Kiyomizu et al [137] also investigated intraintestinal wall distribution and discovered that the concentration of immunoreactive AM and PAMP in the mucosa and submucosa of porcine ileum was significantly higher than in the whole ileum. Apart from the neuroendrocrine cells, AM immunoreactivity is also observed in the smooth muscle cells [129].…”