Brain octopamine and strain differences in avoidance behavior

Delacour, Jean; Coulon, J.F.; David, Jean‐Claude; Guenaire, C.

doi:10.1016/0006-8993(83)90091-4

Cited by 21 publications

(8 citation statements)

References 28 publications

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“…We found that hypothalamic and brainstem levels of phenylethanolamine and rn-and p-OA are higher in the rats of the R H A strain than in those of the RLA; the largest difference was observed for p-OA (David and Delacour, 1980). Intracerebroventricular administration of p-OA, which temporarily suppresses strain differences in the brain levels of this amine, also abolishes the strain differences i n two-way avoidance conditioning (Delacour et al, 1983) by significantly increasing this behavior i n RLA rats.…”

mentioning

confidence: 68%

“…5-HT is also present in higher concentrations in the RHA than in the RLA cerebral cortex (Driscoll et al, 1980). p-OA appears to be associated unequivocally with avoidance conditioning, because its level in RHA brain is significantly higher than that in RLA (David and Delacour, 1980) and because intracerebroventricular administration of this amine mimics high avoidance in normal rats (Delacour et al, 1983).…”

Section: Discussionmentioning

confidence: 95%

“…(1) the differences forp-OA levels in adults rats (David and Delacour, 1980;Delacour et al, 1983) are observed very early during the development of the embryonic hypothalamus and brainstem, but they are higher in RHA than in RCA or RLA; (2) the levels of rn-OA are lower in RHA than in RLA before birth, but become higher in adult animals (David and Delacour, 1980); and (3) levels of NA and DA in embryonic hypothalamus and brain stem are lower than in adults.…”

Section: Discussionmentioning

confidence: 99%

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Prenatal Ontogenesis of Brain Phenolamines and Catecholamines in Relation to Their Metabolizing Enzymes in Roman Avoider Strains of Rats

Coulon

Cavoy

Delacour

et al. 1989

Journal of Neurochemistry

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Phenolamines, particularly octopamines, are of special importance in avoidance behavior. In the Roman low avoidance (RLA) strain, p-octopamine can induce locomotor behavioral activity that is normally observed in the Roman high avoidance (RHA) strain. For these reasons, the levels of prenatal octopamines (para and meta isomers) have been studied in relation to noradrenaline and dopamine levels. In the hypothalamus and brainstem of RHA, a maximum level of the para isomer is observed at 15 days of embryonic development but, unlike in controls and RLA animals, this level remains almost constant until 20 days. For the meta-isomer and catecholamines, there is a 1-2 day delay in detection between controls and RLA or RHA. The study of related enzyme activities reveals that tyrosine hydroxylase displays a 2-day delay in RHA when compared to the control value at 19 days of fetal life. These results are discussed in terms of the role of p-octopamine in avoidance conditioning and of the possible delayed expression of the tyrosine hydroxylase gene in Roman strains of rats.

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confidence: 68%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Prenatal Ontogenesis of Brain Phenolamines and Catecholamines in Relation to Their Metabolizing Enzymes in Roman Avoider Strains of Rats

Coulon

Cavoy

Delacour

et al. 1989

Journal of Neurochemistry

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“…In these experiments rats of the Roman strain, selected for high avoidance (RHA) and low avoidance (RLA) responding were used. It was found that hypothalamic and brain stem levels of p-and m-octopamine were higher in the RHA strain than in the RLA strain (David & Delacour, 1980;Delacour et al, 1983). No differences in NA levels between the strains were observed.…”

Section: Introductionmentioning

confidence: 87%

“…These authors suggested that the strain difference in avoidance responding may be related specifically to endogenous octopamine levels. This idea is supported by the finding that octopamine, administered intraventricularly, temporarily suppressed the strain difference in p-octopamine levels, without affecting NA levels, and facilitated avoidance responding to a greater degree in RLA rats, so that the strain difference in avoidance conditioning was no longer apparent (Delacour et al, 1983).…”

Section: Introductionmentioning

confidence: 91%

m‐Octopamine injected into the paraventricular nucleus induces eating in rats: a comparison with noradrenaline‐induced eating

Fletcher¹,

Paterson²

1989

British J Pharmacology

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1 The effects on food intake in rats of injection of m-and p-octopamine into the paraventricular nucleus (PVN) of the hypothalamus were examined, and compared to the effects of noradrenaline (NA). 2 m-Octopamine injected into the PVN induced a dose-dependent increase in food intake, with the maximal effect occurring at a dose of 25 nmol. p-Octopamine did not elicit eating unless it was administered to animals pretreated with the monoamine oxidase inhibitor, pargyline. 3 The effects of pretreatment with various adrenoceptor antagonists, injected into the PVN, on the eating responses induced by 25 nmol m-octopamine and NA were examined. The a,1-adrenoceptor antagonist, corynanthine, and the fi-adrenoceptor antagonist, propranolol, failed to alter the eating induced by m-octopamine or NA. The effects of these two amines were susceptible to blockade of a2-adrenoceptors. Idazoxan reversed the eating induced by m-octopamine and noradrenaline. However, yohimbine was effective only against the eating induced by m-octopamine. Thus, both m-octopamine and NA appear to act via c2, but not a, or fi-adrenoceptors. 4 Injection of a-methyl-p-tyrosine into the PVN attenuated the effect of m-octopamine, but not of NA. This result suggests that m-octopamine elicits eating, at least in part, by releasing endogenous NA. 5 The NA and octopamine uptake inhibitor, desipramine, significantly potentiated the eating induced by a low dose of m-octopamine. This effect may occur because desipramine would prolong the synaptic activity of released NA. 6 The results indicate that m-octopamine elicits a marked and reliable eating response which is mediated largely by a release of endogenous NA, which acts at a2-receptors. These results are consistent with the view that octopamine may function as a modulator of NA activity in the central nervous system.

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Octopamine: An Endogenous Blocker of Dopamine D-1 Receptors

Tsai

1991

Advances in Experimental Medicine and Biology

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Brain octopamine and strain differences in avoidance behavior

Cited by 21 publications

References 28 publications

Prenatal Ontogenesis of Brain Phenolamines and Catecholamines in Relation to Their Metabolizing Enzymes in Roman Avoider Strains of Rats

Prenatal Ontogenesis of Brain Phenolamines and Catecholamines in Relation to Their Metabolizing Enzymes in Roman Avoider Strains of Rats

m‐Octopamine injected into the paraventricular nucleus induces eating in rats: a comparison with noradrenaline‐induced eating

Octopamine: An Endogenous Blocker of Dopamine D-1 Receptors

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