Brain neuropeptides in gastric mucosal protection

Gyires, Klára; Zádori, Zoltán

doi:10.1016/j.coph.2014.06.002

Cited by 12 publications

(27 citation statements)

References 48 publications

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“…They injected the 14-amino acid neuropeptide bombesin into the cisterna magna and noted the changes in the autonomic nervous system activity, resulting in the simultaneous inhibition of gastric acid and pepsin secretion and motility [42]. In future decades the involvement of neuropeptides in the regulation of the function of gut was confirmed by numerous papers of other authors [6,28,29,41,38,39,43]. Thus, it was shown that opioid peptides, the most numerous family of neuropeptides, have much broader physiological effects than the regulation of emotions.…”

Section: Neuropeptidesmentioning

confidence: 57%

“…Due to the recent literary data, the most explored representatives of oligopeptides with gastroprotective properties are met-enkephaline (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) [27,28] and leu-enkephaline (Tyr-Gly-Gly-Phe-Leu) [27][28][29], demorphine (Н-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH 2 ) and sedatine (H-ArgTyr-D-Ala-Phe-Gly-OH) [5,30], pentadecapeptide BPC 157 (GlyGlu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) [10,[31][32][33]; proline-and hydroxyproline-containing products…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that dalargin (leu-enkephalin) significantly decreased the area of erosive and ulcerative lesions, had a normalizing effect on proliferation of epithelial cells and reduced the degree of oxidative stress [30]. It was also documented that centrally induced gastroprotective effect of neuropeptides may be mediated by a vagal dependent increase of gastric mucosal resistance to injury; activation of vagal cholinergic pathway results in the stimulation of the release of mucosal prostaglandins and nitric oxide [28].Recent papers report that acupuncture can promote the repair of gastric mucosal injury and improve gastrointestinal function and the authors link these effects with reducing plasma beta-endorphin level and upregulating hypothalamic betaendorphin level [46]. It was also noted that endomorphin-2, injected intracerebroventricularly, restored the reduced levels of CGRP and somatostatin in gastric mucosa lesions [27].…”

mentioning

confidence: 99%

“…Oligopeptides were shown to be involved in the regulation of intracellular communication processes, nociception, vessel permeability, neoangiogenesis, nervous impulse transduction as well as affect the activity of hormones and enzymes and exhibit neuro-and immunomodulatory effects [13][14][15][16][17][18][19][20][21]. It is also hypothesized that biological activity of short peptides is mainly associated with their prominent antioxidant properties, although this data is a little bit contradictory as some compounds were reported to have an opposite effect, increasing the processes of oxidation [2,8,16,[24][25][26].Due to the recent literary data, the most explored representatives of oligopeptides with gastroprotective properties are met-enkephaline (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) [27,28] and leu-enkephaline (Tyr-Gly-Gly-Phe-Leu) [27][28][29], demorphine (Н-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH 2 ) and sedatine (H-ArgTyr-D-Ala-Phe-Gly-OH) [5,30], pentadecapeptide BPC 157 (GlyGlu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) [10,[31][32][33]; proline-and hydroxyproline-containing products …”

mentioning

confidence: 99%

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Gastroprotective Oligopeptides

Nasadyuk¹

2015

GHOA

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IntroductionPeptic ulcer disease and its complications still remain a hot issue in modern gastroenterology and one of the constantly important targets for pharmacologic research [1][2][3]. It is commonly acknowledged that nonsteroidal anti-inflammatory drugs (NSAIDs), being the most commonly prescribed group of drugs worldwide for the management of pain and inflammation, play an important role in provoking gastrointestinal tract ulceration, bleeding and perforation [1,4,5]. This mediates the necessity of the effective gastroprotective measures in patients, who are at risk of gastric ulceration, in particular chronic NSAIDs users. Nowadays for this purpose proton pump inhibitors and H 2 -antagonists are commonly used, but due to side effects of these drugs the search for new compounds with gastroprotective properties, suitable for longterm use, remains actual [1,2]. Contemporary literature gives accumulating evidence that a number of oligopeptides play an important role in the regulation of the function of gastrointestinal tract and their synthetic analogues were reported to be effective in the prevention and treatment of gastric ulceration [1,[5][6][7][8][9][10][11][12].That is why the purpose of this review was to summarize the current data on the oligopeptides with documented gastroprotective properties and their possible mechanisms of action. DiscussionDue to the modern outlook, regulatory peptides are considered to be phylogenetically the oldest form of bioregulation [13][14][15][16][17][18][19][20][21]. Thus, the mechanisms of peptidergic regulation of homeostasis open huge perspectives for the creation of the essentially new methods for the prevention and treatment of different diseases [13][14][15][16]. Interestingly, deep studies of the mechanisms of action of regulatory peptides showed that in many cases life-sustaining processes are regulated not by the total peptide molecules but their short-chained derivatives -oligopeptides that are produced in the course of limited proteolysis from proteins-precursors (cytokines, thymic peptides, immunoglobulins) [13,14,18,20,21].The term "oligopeptide" refers to proteins, composed of not more than 20 amino acid residues [22]. For example, it was shown that the inhibition of pancreatic juice secretion by 28-amino acidscontaining hormone ghrelin is realized by its biologically active part -pentapeptide with the sequence of amino acids Gly-Ser-Ser (n-octanoyl)-Phe [23].The advantages of the short peptides above their long-chain derivatives are high biological activity, that often many fold exceeds the activity of the peptide-precursor, high tissue specificity, lack of species specificity and lack of immunogenicity [13,14,[15][16][17][18]20,21]. It was established that low-weighing oligopeptides realize their effect on the cellular, chromosomal, genomic and molecular levels [13][14][15][16][17][18][19][20][21]. The interaction with DNA was proposed to be the key moment of the realization of the biological effect of the short peptides [17][18][19]21]. This concept is s...

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Section: Neuropeptidesmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Gastroprotective Oligopeptides

Nasadyuk¹

2015

GHOA

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“…amylin, adrenomedullin, neurotensin, opioid peptides, melatonin, ghrelin, leptin, as well as cannabinoids were shown to initiate gastroprotective effect given centrally (i.c.v., i.c. or DMNV), mostly by a vagal dependent mechanism [139][140][141][142] (see reviews: [4,127,138,143,144]). …”

Section: Role Of Capsaicin Sensitive Afferent Fibers and In The Actiomentioning

confidence: 99%

The Role of Capsaicin-Sensitive Afferent Nerves in Gastric Mucosal Protection Initiated Centrally or Peripherally under Experimental Conditions

Gyires¹

2014

Capsaicin - Sensitive Neural Afferentation and the Gastrointestinal Tract: From Bench to Bedside

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Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility

et al. 2016

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Background. Allyphenyline, a novel α2-adrenoceptor (AR) ligand has been shown to selectively activate α2C-adrenoceptors (AR) and 5HT1A receptors, but also to behave as a neutral antagonist of α2A-ARs. We exploited this unique pharmacological profile to analyze the role of α2C-ARs and 5HT1A receptors in the regulation of gastric mucosal integrity and gastrointestinal motility. Methods. Similar inhibition was observed in the colon, however, in this case only ARC 239 reduced this effect, while neither selective inhibition of α2C-ARs and 5HT1A receptors, nor genetic deletion of α2A-and α2B-ARs influenced it. Conclusions. Activation of both central α2C-ARs and 5HT1A receptors contributes to the gastroprotective action of allyphenyline in rats. Its inhibitory effect on fundic contractions is mediated by 5HT1A receptors, but neither α2-ARs, nor 5HT1A receptors take part in its inhibitory effect on colonic contractility in mice.

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Brain neuropeptides in gastric mucosal protection

Cited by 12 publications

References 48 publications

Gastroprotective Oligopeptides

Gastroprotective Oligopeptides

The Role of Capsaicin-Sensitive Afferent Nerves in Gastric Mucosal Protection Initiated Centrally or Peripherally under Experimental Conditions

Dual Alpha2C/5HT1A Receptor Agonist Allyphenyline Induces Gastroprotection and Inhibits Fundic and Colonic Contractility

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