Brain neuropeptides in central ventilatory and cardiovascular regulation in trout

Mével, Jean-Claude Le; Lancien, Frédéric; Mimassi, Nagi; Conlon, J. Michael

doi:10.3389/fendo.2012.00124

Cited by 13 publications

(9 citation statements)

References 166 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The receptor site(s) and the multisynaptic pathways involved in initiating cardio-ventilatory and locomotor responses after UII, URP1, and URP2 injection within the brain are matter of speculation and require further studies. Nevertheless, as previously mentioned for the central actions of other neuropeptides, some neuroanatomical prerequisites and some neurophysiological data exist that may support some working hypothesis (Le Mével et al, 2012 ). Because the peptides were injected within the third ventricle in close proximity to the preoptic nucleus (NPO), they can activate these preoptic neurons leading to hyperventilatory and hypertensive responses through neuroendocrine and/or neurogenic pathways.…”

Section: Discussionmentioning

confidence: 60%

“…The fish received first an ICV injection of vehicle (0.5 μl) and 30 min later, an ICV injection of UII, URP1, or URP2 (5, 50, and 500 pmol in 0.5 μl). The rationale for using these doses was that they were in the same range as those previously used for studies on the cardiovascular effects of UII in trout and for comparison of effects between peptides (Le Mével et al, 1996 , 2012 ). Previous control experiments using two ICV injections 30 min apart have shown no time-dependent changes in the measured variables using this protocol (Le Mével et al, 2009 ).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Divergent cardio-ventilatory and locomotor effects of centrally and peripherally administered urotensin II and urotensin II-related peptides in trout

et al. 2015

Self Cite

View full text Add to dashboard Cite

The urotensin II (UII) gene family consists of four paralogous genes called UII, UII-related peptide (URP), URP1 and URP2. UII and URP peptides exhibit the same cyclic hexapeptide core sequence (CFWKYC) while the N- and C-terminal regions are variable. UII, URP1, and URP2 mRNAs are differentially expressed within the central nervous system of teleost fishes, suggesting that they may exert distinct functions. Although the cardiovascular, ventilatory and locomotor effects of UII have been described in teleosts, much less is known regarding the physiological actions of URPs. The goal of the present study was to compare the central and peripheral actions of picomolar doses (5–500 pmol) of trout UII, URP1, and URP2 on cardio-ventilatory variables and locomotor activity in the unanesthetized trout. Compared to vehicle, intracerebroventricular injection of UII, URP1 and URP2 evoked a gradual increase in total ventilation (VTOT) reaching statistical significance for doses of 50 and 500 pmol of UII and URP1 but for only 500 pmol of URP2. In addition, UII, URP1 and URP2 provoked an elevation of dorsal aortic blood pressure (PDA) accompanied with tachycardia. All peptides caused an increase in locomotor activity (ACT), at a threshold dose of 5 pmol for UII and URP1, and 50 pmol for URP2. After intra-arterial (IA) injection, and in contrast to their central effects, only the highest dose of UII and URP1 significantly elevated VTOT and ACT. UII produced a dose-dependent hypertensive effect with concomitant bradycardia while URP1 increased PDA and heart rate after injection of only the highest dose of peptide. URP2 did not evoke any cardio-ventilatory or locomotor effect after IA injection. Collectively, these findings support the hypothesis that endogenous UII, URP1 and URP2 in the trout brain may act as neurotransmitters and/or neuromodulators acting synergistically or differentially to control the cardio-respiratory and locomotor systems. In the periphery, the only physiological actions of these peptides might be those related to the well-known cardiovascular regulatory actions of UII. It remains to determine whether the observed divergent physiological effects of UII and URPs are due to differential interaction with the UT receptor or binding to distinct UT subtypes.

show abstract

Section: Discussionmentioning

confidence: 60%

Section: Methodsmentioning

confidence: 99%

Divergent cardio-ventilatory and locomotor effects of centrally and peripherally administered urotensin II and urotensin II-related peptides in trout

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…These sporadic and short lasting ventilatory effects of peripheral administered GRP might also be due to direct action of the peptide on critical target sites in the brain that lack the blood brain barrier. Interestingly, we never observed this pattern of ventilatory episodes for any of the previously neuropeptides tested (reviewed by Le Mével et al, 2012). The mechanisms that mediate this effect and its physiological significance, if any, are at present unclear and warrant further studies.…”

Section: Discussionmentioning

confidence: 62%

“…The present results add GRP to the list of peptides (Le Mével et al, 2012) that act centrally as metabotropic neurotransmitters to modulate the neuronal outputs that ultimately affect the ventilatory and cardiovascular effectors in the trout model. The hyperventilatory and hypertensive actions of central GRP may be viewed as cardio-ventilatory mechanisms to protect against adverse hypoventilation and hypotension.…”

Section: Discussionmentioning

confidence: 69%

“…This neuroanatomical singularity suggests that these neurons can sense the composition of the cerebrospinal fluid and/or release their products within the ventricular system. Exogenous GRP within the third ventricle may stimulate GRP neurons or other neurons that project their axons to the cardioventilatory centers within the brainstem (Le Mével et al, 2012). In the goldfish, functional-anatomical studies have demonstrated the existence of a neural pathway from the preoptic area to the dorsal motor nucleus of the vagus controlling concomitantly ventilation and ƒH (Hornby and Demski, 1988).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Central ventilatory and cardiovascular actions of trout gastrin-releasing peptide (GRP) in the unanesthetized trout

et al. 2013

Self Cite

View full text Add to dashboard Cite

SummaryGastrin-releasing peptide (GRP), a neuropeptide initially isolated from porcine stomach, shares sequence similarity with bombesin. GRP and its receptors are present in the brains and peripheral tissues of several species of teleost fish, but little is known about the ventilatory and cardiovascular effects of this peptide in these vertebrates. The goal of this study was to compare the central and peripheral actions of picomolar doses of trout GRP on ventilatory and cardiovascular variables in the unanesthetized rainbow trout. Compared to vehicle, intracerebroventricular (ICV) injection of GRP (1–50 pmol) significantly elevated the ventilation rate (ƒV) and the ventilation amplitude (VAMP), and consequently the total ventilation (VTOT). The maximum hyperventilatory effect of GRP (VTOT: +225%), observed at a dose of 50 pmol, was mostly due to its stimulatory action on VAMP (+170%) rather than ƒV (+20%). In addition, ICV GRP (50 pmol) produced a significant increase in mean dorsal aortic blood pressure (PDA) (+35%) and in heart rate (ƒH) (+25%). Intra-arterial injections of GRP (5–100 pmol) were without sustained effect on the ventilatory variables but produced sporadic and transient increases in ventilatory movement at doses of 50 and 100 pmol. At these doses, GRP elevated PDA by +20% but only the 50 pmol dose significantly increased HR (+15%). In conclusion, our study suggests that endogenous GRP within the brain of the trout may act as a potent neurotransmitter and/or neuromodulator in the regulation of cardio-ventilatory functions. In the periphery, endogenous GRP may act as locally-acting and/or circulating neurohormone with an involvement in vasoregulatory mechanisms.

show abstract

Brainstem mechanisms controlling cardiovascular reflexes in channel catfish

Turesson

Hedrick

Sundin

et al. 2014

Comparative Biochemistry and Physiology Part A: Molecular &

View full text Add to dashboard Cite

Brain neuropeptides in central ventilatory and cardiovascular regulation in trout

Cited by 13 publications

References 166 publications

Divergent cardio-ventilatory and locomotor effects of centrally and peripherally administered urotensin II and urotensin II-related peptides in trout

Divergent cardio-ventilatory and locomotor effects of centrally and peripherally administered urotensin II and urotensin II-related peptides in trout

Central ventilatory and cardiovascular actions of trout gastrin-releasing peptide (GRP) in the unanesthetized trout

Brainstem mechanisms controlling cardiovascular reflexes in channel catfish

Contact Info

Product

Resources

About