Brain natriuretic peptide as a predictor of heart failure in patients with permanent pacemaker

Abstract

The increased BNP levels can be valuable for early screening of patients with higher risk of heart failure. In patients with increased BNP at the time of pacemaker implantation, DDD pacing is a modality of choice.

BNP/NT‐ProBNP and Cardiac Pacing: A Review

“…No matter whether physiologic pacing, nonphysiologic pacing, or CRT is performed, if NP levels increase postoperatively, it often indicates that HF begins to occur, even without any clinical manifestations of HF. BNP can be used as a screening tool for HF in the pacemaker population, 32 an independent predictor of HF in patients with permanent pacemaker 33 and a valuable routine parameter for monitoring the effects of CRT in patients with HF. These findings have important clinical implications, that is, physiologic pacing should firstly be chosen in patients with only a standard indication for antibradycardia pacing, and AAI(R) is the best pacing mode if atrioventricular conduction is normal.…”

Prognostic value of NT-proBNP levels in patients undergoing permanent pacemaker implantation

“…It was demonstrated that BNP could be of value in screening for heart failure or a prognostic factor of developing heart failure in patients after pacemaker implantation. 15,16 Moreover, BNP was able to predict chronic atrial fibrillation after VVIR pacemaker in patients with sick sinus syndrome (SSS). 17 In 2000, when the abovementioned study was published, the unfavorable effects of VVIR stimulation were not yet fully understood.…”

“…This is in contrast to the population without permanent pacing devices, pg/ml, 80% develop severe heart failure during a 6-year follow-up. 16 Importantly, the mode of stimulation itself has an impact on the future occurrence of cardiovascular events. Saccomanno et al 19 reported higher rate of such events in VVI mode as compared with DDD stimulation.…”