Brain natriuretic peptide and N-terminal brain natriuretic peptide for the diagnosis of haemodynamically significant patent ductus arteriosus in preterm neonates

NT-proBNP cardiac value in COVID-19: a focus on the paediatric population

“…70 However, no study has shown that NT-proBNP could be the sole diagnostic biomarker of a potential heart failure, and many have shown that it constitutes a supplement to echocardiography, not a replacement. [71][72][73] Echocardiography still plays a central role in the diagnosis and evaluation of heart failure, 74,75 and it is clearly essential in the evaluation of patients with heart failure with preserved ejection fraction, in terms of both diagnosis and prognosis. 76 As for the relationship between heart failure with preserved ejection fraction and heart failure with reduced ejection fraction with NT-proBNP, a study by Salah et al demonstrated that patients with these two conditions have the same relative risk of 6-month death predicted by absolute discharge NT-proBNP levels or by percentage changes in NT-proBNP.…”

Optimizing diagnosis and treatment of infants with congenital heart disease and pneumonia: A 15 years’ experience

“…Уровень артериальной гипоксемии определялся по данным транскутанного мониторирования SpO2, кислотно-основного соотношения (SpO2, pO2). Биохимический анализ маркеров миокардиального повреждения включал определение ЛДГ и ЛДГ1,2, КФК и КФК-МВ, Тропонина I и ANP-предсердного натрийуретического пептида и BNP-мозгового натрийуретического пептида, как показателей миокардиальной дисфункции и сердечной недостаточности [36,37,38].…”

“…Легочная гипертензия (ЛГ) по данным эхокардиографии с САД>36 мм.рт.ст. [38] К сожалению, современная лабораторная диагностика позволяет установить этиологический диагноз не более чем в 20-50% случаев, при этом особенности клиникорентгенологической картины не считаются «адекватно отражающими этиологию заболевания» [30,31,32]. Наши многолетние наблюдения позволили установить вероятную смешанную вирусно-бактериальную этиологию пневмонии у трети пациентов основной группы по данным серологического обследования.…”

Diagnostic Accuracy of Urinary N Terminal pro-B Type Natriuretic Peptides for Hemodynamically Significant-Patent Ductus Arteriosus in Preterm Infants

“…There is currently no consensus in the literature regarding how to define a hs-PDA; however, most studies include a combination of echocardiographic findings, clinical signs and symptoms, and markers of end-organ dysfunction [1]. The hemodynamic significance of a PDA in preterm neonates has been defined at least one or a combination of (1) general clinical signs (clinical signs of hyperdynamic circulation, which includes respiratory signs (increased respiratory support, inability to wean, need for oxygen support)); (2) cardiac physical signs (a hyperdynamic precordium or bounding pulses, increased pulse pressure (difference between systolic and diastolic blood pressures), signs of congestive heart failure); or (3) echocardiographic parameters (left atrium-to-aortic root [LA/Ao] ratio >1.5, ductal diameter >1.5 mm [using color Doppler]) [2]. The left-to-right shunting across the PDA can result in pulmonary over-circulation and systemic steal phenomenon, thus leading to end-organ dysfunction, clinically manifesting as an increased risk of bronchopulmonary dysplasia, intraventricular hemorrhage, acute kidney injury, necrotizing enterocolitis, pulmonary hemorrhage, and death [3].…”