Brain MRI Findings in Patients in the Intensive Care Unit with                     COVID-19 Infection

Kandemirli, Sedat Giray; Doğan, Lerzan; Sarıkaya, Zeynep Tuğçe; Kara, Simay; Akıncı, Canan; Kaya, Dilaver; Yıldız, Kaya; Yıldırım, Düzgün; Tüzüner, Filiz; Yı́ldı́rı́m, Mustafa; Özlük, Enes; Güçyetmez, Bülent; Karaarslan, Ercan; Köylüoğlu, Işıl; Kaya, Hande Simten Demirel; Mammadov, Orkhan; Özdemir, İlkay; Afşar, Nazire; Yalçınkaya, Beyza Çitçi; Rasimoğlu, Sevdinaz; Güdük, Duygu Emine; Jima, Ararso Kedir; İlksoz, Aylin; Ersöz, Vildan; Eren, Meltem Yonca; Çeltik, Nilüfer; Arslan, Serdar; Korkmazer, Bora; Dinçer, Şaban Selçuk; Gulek, Elif; Dikmen, Ibrahim; Yazici, Murathan; Ünsal, Serkan; Ljama, Taner; Demirel, İsmail; Ayyildiz, Aykut; Kesimci, Işıl; Deveci, Şahika Bolsoy; Tütüncü, Melih; Kızılkılıç, Osman; Telci, Lütfi; Zengin, Rehile; Di̇nçer, Alp; Akıncı, İbrahim Özkan; Koçer, Naci

doi:10.1148/radiol.2020201697

Cited by 263 publications

(331 citation statements)

References 17 publications

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“…An updated literature search for studies published between July 30, 2020 and October 9, 2020 resulted in 346 studies, of which seven studies met the same eligibility criteria [ [27] , [28] , [29] , [30] , [31] , [32] , [33] ]. Overall, 21 articles with a total of 2125 patients were included [ 4 , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] ]. No additional eligible study was found after a search of references within the included studies.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 21 studies, all study designs were retrospective, except for two prospective studies [ 28 , 39 ]. Nine studies were multi-center studies [ 4 , 29 , 31 , 33 , 36 , 38 , 40 , 42 , 43 ] whereas the other 12 were performed at single centers [ 27 , 28 , 30 , 32 , 34 , 35 , 37 , 39 , 41 , [44] , [45] , [46] ]. The cohort sizes ranged from 9 to 454 patients.…”

Section: Resultsmentioning

confidence: 99%

“…The cohort sizes ranged from 9 to 454 patients. The countries of origin of the selected studies were heterogeneous, including China [ 40 ], Turkey [ 42 ], Europe [ 4 , 30 , [35] , [36] , [37] , 39 , 41 , 43 , 45 , 46 ], and the USA [ 27 , 28 , [31] , [32] , [33] , [34] , 38 , 44 ]. One study was a multinational study involving all three continents [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…One study was a multinational study involving all three continents [ 29 ]. Brain MRI was the only neuroimaging modality used in ten of the studies [ 4 , 28 , 32 , 33 , 37 , 39 , [41] , [42] , [43] , [44] ] whereas ten studies used brain CT and/or MRI [ 27 , [29] , [30] , [31] , [34] , [35] , [36] , 38 , 45 , 46 ]; one study used only brain CT [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Neuroimaging findings of brain MRI and CT in patients with COVID-19: A systematic review and meta-analysis

Choi

Lee

2020

European Journal of Radiology

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Neuroimaging findings of brain MRI and CT in patients with COVID-19: A systematic review and meta-analysis

Choi

Lee

2020

European Journal of Radiology

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“…67,68 A Turkish study showed that 12/27 patients (44%) showed abnormalities on brain MRI with signs suggestive of ischemia or menigoencephalitis. 69 Of note, only minimal evidence points to direct infection of neurons/glial cells by SARS-CoV-2 viral particles, as shown by mostly negative RT-PCR analyses from CSF (Table S7). 53,64,66 Nevertheless, CSF from a small subset of patients with encephalitic features did test positive for SARS-CoV-2 RNA.…”

Section: Neurological Complicationsmentioning

confidence: 99%

Neurological manifestations of coronavirus infections – a systematic review

Almqvist

Granberg

Tzortzakakis

et al. 2020

Ann Clin Transl Neurol

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To optimize diagnostic workup of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we systematically reviewed neurological and neuroradiological manifestations of SARS-CoV-2 and all other known human coronavirus species (HCoV). Which lessons can we learn? We identified relevant publications (until 26 July 2020) using systematic searches in PubMed, Web of Science, and Ovid EMBASE with predefined search strings. A total of 4571 unique publications were retrieved, out of which 378 publications were selected for in-depth analysis by two raters, including a total of 17549 (out of which were 14418 SARS-CoV-2) patients. Neurological complications and associated neuroradiological manifestations are prevalent for all HCoVs (HCoV-229E, HKU1, NL63, OC43, Middle East respiratory syndrome (MERS)-CoV, SARS-CoV-1, and SARS-CoV-2). Moreover there are similarities in symptomatology across different HCoVs, particularly between SARS-CoV-1 and SARS-CoV-2. Common neurological manifestations include fatigue, headache, and smell/taste disorders. Additionally, clinicians need to be attentive for at least five classes of neurological complications: (1) Cerebrovascular disorders including ischemic stroke and macro/micro-hemorrhages, (2) encephalopathies, (3) para-/postinfectious immune-mediated complications such as Guillain-Barr e syndrome and acute disseminated encephalomyelitis, (4) (meningo-)encephalitis, potentially with concomitant seizures, and (5) neuropsychiatric complications such as psychosis and mood disorders. Our systematic review highlights the need for vigilance regarding neurological complications in patients infected by SARS-CoV-2 and other HCoVs, especially since some complications may result in chronic disability. Neuroimaging protocols should be designed to specifically screen for these complications. Therefore, we propose practical imaging guidelines to facilitate the diagnostic workup and monitoring of patients infected with HCoVs. additional HCoV species (HCoV-229E, HCoV-HKU1, HCoV-NL63, and HCoV-OC43) cause disease in humans, albeit typically with milder clinical courses. 3 While coronaviruses primarily target the human respiratory system, 4 they can also enter the central nervous system (CNS). This is evident from pre-clinical research, where murine coronaviruses have been used to model human encephalitis for decades. 5 HCoVs also show neurotropism. SARS-CoV-1 6 and SARS-CoV-2 7 both use the cell membrane-bound human angiotensin-converting enzyme 2 for cellular entry, which is, among other tissues, expressed on vascular endothelial cells in the brain. 8 Yet, SARS-CoV-2 seems to have an even higher affinity to bind to this receptor compared to SARS-CoV-1. 9 SARS-CoV-1 and SARS-CoV-2 are also most related genetically, with 79% genome homology. 10 Therefore, it is not surprising that several studies have described neurological symptomatology in both SARS-CoV-1 and SARS-CoV-2 infections. 3,11 Neurological complications have also been described in other HCoVs. 12 The aim of this study ...

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Self-reported Memory Problems 8 Months After COVID-19 Infection

Søraas

Bø

Kalleberg³

et al. 2021

JAMA Netw Open

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COVID-19 is an airway disease that also affects the nervous system. 1 Therefore, neurological and neurocognitive symptoms may be a part of the postacute sequelae of SARS-CoV-2 infection (PASC) syndrome. PASC may be found to affect a high proportion of people who had mild cases of COVID-19, and there is an urgent need for a detailed description of PASC in nonhospitalized patients. 2,3 This cohort study examines self-reported memory problems 8 months after COVID-19 infection. MethodsThis cohort study was approved by the Regional Research Ethics Committee according to the Declaration of Helsinki. Eligible participants provided informed consent by signing an online electronic consent form and completing an online baseline questionnaire and follow-up questionnaires. This study used the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline.We followed a cohort of 13 001 adults who were invited after (1) having their clinical specimen analyzed for SARS-CoV-2 at 4 large accredited laboratories in Norway or (2) being randomly selected from the Norwegian population (untested). All adults who were tested for COVID between February Author affiliations and article information are listed at the end of this article.

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Brain MRI Findings in Patients in the Intensive Care Unit with COVID-19 Infection

Abstract: Online supplemental material is available for this article.

Cited by 263 publications

References 17 publications

Neuroimaging findings of brain MRI and CT in patients with COVID-19: A systematic review and meta-analysis

Neuroimaging findings of brain MRI and CT in patients with COVID-19: A systematic review and meta-analysis

Neurological manifestations of coronavirus infections – a systematic review

Self-reported Memory Problems 8 Months After COVID-19 Infection

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