Brain morphometry in female victims of intimate partner violence with and without posttraumatic stress disorder

Fennema-Notestine, Christine; Stein, Murray B.; Kennedy, Colleen M.; Archibald, Sarah; Jernigan, Terry L.

doi:10.1016/s0006-3223(02)01413-0

Cited by 238 publications

(166 citation statements)

References 41 publications

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“…[28][29][30][31] Similarly, several groups found smaller bilateral hippocampi in patients with PTSD, 32,33 whereas others were unable to find significantly smaller hippocampi in PTSD. [34][35][36] In MD, significantly smaller bilateral hippocampal volumes have been reported by some, 11,37,38 but not by others. 39,40 Part of the discrepancy among research findings may be attributed to the use of different methods for establishing hippocampal volume.…”

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confidence: 89%

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

2004

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The advance of neuroimaging techniques has resulted in a burgeoning of studies reporting abnormalities in brain structure and function in a number of neuropsychiatric disorders. Measurement of hippocampal volume has developed as a useful tool in the study of neuropsychiatric disorders. We reviewed the literature and selected all English-language, human subject, data-driven papers on hippocampal volumetry, yielding a database of 423 records. From this database, the methodology of all original manual tracing protocols were studied. These protocols differed in a number of important factors for accurate hippocampal volume determination including magnetic field strength, the number of slices assessed and the thickness of slices, hippocampal orientation correction, volumetric correction, software used, inter-rater reliability, and anatomical boundaries of the hippocampus. The findings are discussed in relation to optimizing determination of hippocampal volume.

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confidence: 89%

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

2004

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“…In a number of cases, such trait factors indeed had a significant influence on hippocampal volume (eg, De Bellis et al, 2002;Fennema-Notestine et al, 2002;Gurvits et al, 1996;Lindauer et al, 2004;MacQueen et al, 2003;Rusch et al, 2001;Villarreal et al, 2002). While this approach cannot provide mechanistic information, it can 'refine' a diagnosis with the help of theoretically and operationally better defined entities.…”

Section: Introductionmentioning

confidence: 99%

Anxiety and Hippocampus Volume in the Rat

Kalisch

Schubert

Jacob

et al. 2005

Neuropsychopharmacol

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In depressed patients as well as healthy controls, a positive relationship between hippocampal volume and trait anxiety has been reported. This study sought to explore the possible inter-relation between hippocampal volume and trait anxiety further. Magnetic resonance imaging at 7 T was used to measure hippocampal volumes in a rat model of extremes in trait anxiety (experiment 1) and in a Wistar population with normal anxiety-related behavior (experiment 2). In addition to anxiety-related behavior, potentially confounding factors (depression-like, exploratory, and locomotor behavior) were assessed. Experiment 1 globally supported the hypothesis of a positive relationship between hippocampus volume and trait anxiety but did not allow for ruling out possible confounds arising from cosegregation of other behavioral traits. Experiment 2 yielded strong evidence for a negative relationship which was specific for trait anxiety. Thus, the relationship between hippocampal volume and anxiety may be more complex than expected. Interestingly, anxietyrelated behavior in experiment 2 had a stronger influence on hippocampal volume than depression-like behavior. In the light of hippocampal volume loss in anxiety disorder and frequent comorbidity of anxiety and depression, this finding suggests that further research into the relationship between anxiety and hippocampal volume may be critical for understanding hippocampal contributions to normal and pathological behavior. Neuropsychopharmacology (2006) 31, 925-932.

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“…Written informed consent was obtained from all subjects in the study. The sample size for this study was projected based on previous research (Lindauer et al, 2004a;Fennema-Notestine et al, 2002;Jatzko et al, 2006a;Abe et al, 2006) where sample sizes ranging from eight to twenty were reported. VoR subjects: VoR subjects were recruited in two stages.…”

Section: Subjectsmentioning

confidence: 99%

“…For example, studies have shown that patients with PTSD are associated with bilateral lower hippocampal volume (Bossini & Castrogiovanni, 2007;Bremner et al, 2003;Emdad et al, 2006;Lindauer et al, 2004a;Vythilingam et al, 2005;Li et al, 2006), which are www.intechopen.com considered to be either due to atrophy of the hippocampus as a consequence of suffering from PTSD due to excessive stress (Bremner et al, 1995;Gurvits et al, 1996) or that hippocampal volume to be a risk factor for developing PTSD (Gilbertson et al, 2002). Other studies report unchanged hippocampal volumes in female patients with chronic PTSD traumatized by intimate partner violence (Fennema-Notestine et al, 2002), those traumatized by witnessing a plane crash at the same air show (Jatzko et al, 2006a), elderly PTSD patients (Golier et al, 2006), and adult burn patients (Winter & Irle, 2004). Opposite trends in abused juveniles were found in other studies.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have shown that the medial prefrontal cortex, which includes the anterior cingulate cortex and medial frontal cortex, are involved in the process of extinction of fear conditioning and the retention of extinction (Milad et al, 2006). Research on abnormalities in the prefrontal cortex in PTSD patients suggested decreased volume (Fennema-Notestine et al, 2002;Carrion et al, 2001;Richert et al, 2006;Hakamata et al, 2007), while some findings suggested increased volume of the middle-inferior and ventral regions of the prefrontal cortex (Richert et al, 2006). The cerebellum has been considered only as a classical subcortical center for motor control (Botez, 1993).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Abnormal Brain Density in Victims of Rape with PTSD in Mainland China: A Voxel-Based Analysis of Magnetic Resonance Imaging Study

Sui¹,

Li²,

Zhang³

et al. 2011

Neuroimaging for Clinicians - Combining Research and Practice

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Brain morphometry in female victims of intimate partner violence with and without posttraumatic stress disorder

Cited by 238 publications

References 41 publications

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

Anxiety and Hippocampus Volume in the Rat

Abnormal Brain Density in Victims of Rape with PTSD in Mainland China: A Voxel-Based Analysis of Magnetic Resonance Imaging Study

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