Brain Morphology in Older African Americans, Caribbean Hispanics, and Whites From Northern Manhattan

Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment

“…Modeling HAR using multiple volume measurements over a 4 year time period in a linear regression model allowed us to capture volume changes over a longer time period than many other studies, while better controlling for random variations in volume measurement over time. Compared to previous cross-sectional studies that reported an association of age and hippocampal volume in older adult NC (Brickman et al, 2008; Jack et al, 1997), we find no association between HAR and age in an adjusted multivariable model. Our work confirms that of previous studies showing a correlation between Aβ levels and HAR in older adult NC (Fjell et al, 2010; Schott et al, 2010), and extends these findings using HAR measured longitudinally over a longer time span, with multiple data points per participant.…”

Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment

“…Modeling HAR using multiple volume measurements over a 4 year time period in a linear regression model allowed us to capture volume changes over a longer time period than many other studies, while better controlling for random variations in volume measurement over time. Compared to previous cross-sectional studies that reported an association of age and hippocampal volume in older adult NC (Brickman et al, 2008; Jack et al, 1997), we find no association between HAR and age in an adjusted multivariable model. Our work confirms that of previous studies showing a correlation between Aβ levels and HAR in older adult NC (Fjell et al, 2010; Schott et al, 2010), and extends these findings using HAR measured longitudinally over a longer time span, with multiple data points per participant.…”

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

“…Consistent with existing literature ( Jeerakathil et al, 2004 ; Seshadri et al, 2004 ; Brickman et al, 2008 ; Srinivasa et al, 2016 ), our results indicated that both medium and high CVD risk groups were associated with smaller total brain, gray matter, and frontal brain volumes as well as larger WMH volumes compared to the low CVD risk group. In the predominantly non-Hispanic/Latino white Framingham Offspring Study, higher CVD risk was associated with smaller total brain ( Seshadri et al, 2004 ), larger WMH volumes, and lower cognitive performance ( Elias et al, 2004 ; Jeerakathil et al, 2004 ; Au et al, 2006 ).…”

Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

“…Additionally, women demonstrated more stability across the aging spectrum (i.e., less age-related differences) in global brain volumes and hippocampal, temporal, and occipital gray matter volumes compared to men. Thus, consistent with several cross-sectional and longitudinal studies ( Brickman et al, 2008 ; Cowell et al, 1994 ; DeCarli et al, 2005 ; Driscoll et al, 2009 ; Geerlings et al, 2010 ; Raz et al, 2004a ), we observed relative brain structure advantages among women compared to men, although the degree of sex differences was sometimes small ( Fotenos et al, 2005 ). Small differences in brain aging within a cognitively healthy sample, as seen in the present study, could indicate differential risk for ADRD and preclinical stages of Alzheimer’s disease ( Fotenos et al, 2005 ).…”

Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment

“…Modeling HAR using multiple volume measurements over a 4 year time period in a linear regression model allowed us to capture volume changes over a longer time period than many other studies, while better controlling for random variations in volume measurement over time. Compared to previous cross-sectional studies that reported an association of age and hippocampal volume in older adult NC (Brickman et al, 2008; Jack et al, 1997), we find no association between HAR and age in an adjusted multivariable model. Our work confirms that of previous studies showing a correlation between Aβ levels and HAR in older adult NC (Fjell et al, 2010; Schott et al, 2010), and extends these findings using HAR measured longitudinally over a longer time span, with multiple data points per participant.…”

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

“…Consistent with existing literature ( Jeerakathil et al, 2004 ; Seshadri et al, 2004 ; Brickman et al, 2008 ; Srinivasa et al, 2016 ), our results indicated that both medium and high CVD risk groups were associated with smaller total brain, gray matter, and frontal brain volumes as well as larger WMH volumes compared to the low CVD risk group. In the predominantly non-Hispanic/Latino white Framingham Offspring Study, higher CVD risk was associated with smaller total brain ( Seshadri et al, 2004 ), larger WMH volumes, and lower cognitive performance ( Elias et al, 2004 ; Jeerakathil et al, 2004 ; Au et al, 2006 ).…”

Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

“…Additionally, women demonstrated more stability across the aging spectrum (i.e., less age-related differences) in global brain volumes and hippocampal, temporal, and occipital gray matter volumes compared to men. Thus, consistent with several cross-sectional and longitudinal studies ( Brickman et al, 2008 ; Cowell et al, 1994 ; DeCarli et al, 2005 ; Driscoll et al, 2009 ; Geerlings et al, 2010 ; Raz et al, 2004a ), we observed relative brain structure advantages among women compared to men, although the degree of sex differences was sometimes small ( Fotenos et al, 2005 ). Small differences in brain aging within a cognitively healthy sample, as seen in the present study, could indicate differential risk for ADRD and preclinical stages of Alzheimer’s disease ( Fotenos et al, 2005 ).…”

Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment

“…Modeling HAR using multiple volume measurements over a 4 year time period in a linear regression model allowed us to capture volume changes over a longer time period than many other studies, while better controlling for random variations in volume measurement over time. Compared to previous cross-sectional studies that reported an association of age and hippocampal volume in older adult NC (Brickman et al, 2008; Jack et al, 1997), we find no association between HAR and age in an adjusted multivariable model. Our work confirms that of previous studies showing a correlation between Aβ levels and HAR in older adult NC (Fjell et al, 2010; Schott et al, 2010), and extends these findings using HAR measured longitudinally over a longer time span, with multiple data points per participant.…”

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

“…Consistent with existing literature ( Jeerakathil et al, 2004 ; Seshadri et al, 2004 ; Brickman et al, 2008 ; Srinivasa et al, 2016 ), our results indicated that both medium and high CVD risk groups were associated with smaller total brain, gray matter, and frontal brain volumes as well as larger WMH volumes compared to the low CVD risk group. In the predominantly non-Hispanic/Latino white Framingham Offspring Study, higher CVD risk was associated with smaller total brain ( Seshadri et al, 2004 ), larger WMH volumes, and lower cognitive performance ( Elias et al, 2004 ; Jeerakathil et al, 2004 ; Au et al, 2006 ).…”

Characterizing age- and sex-related differences in brain structure among middle-aged and older Hispanic/Latino adults in the study of Latinos- investigation of neurocognitive aging magnetic resonance imaging (SOL-INCA MRI)

“…Additionally, women demonstrated more stability across the aging spectrum (i.e., less age-related differences) in global brain volumes and hippocampal, temporal, and occipital gray matter volumes compared to men. Thus, consistent with several cross-sectional and longitudinal studies ( Brickman et al, 2008 ; Cowell et al, 1994 ; DeCarli et al, 2005 ; Driscoll et al, 2009 ; Geerlings et al, 2010 ; Raz et al, 2004a ), we observed relative brain structure advantages among women compared to men, although the degree of sex differences was sometimes small ( Fotenos et al, 2005 ). Small differences in brain aging within a cognitively healthy sample, as seen in the present study, could indicate differential risk for ADRD and preclinical stages of Alzheimer’s disease ( Fotenos et al, 2005 ).…”