Brain monoamine oxidase activity after chronic ethanol treatment of rats

Wiberg, A; Wahlstroöm, G; Oreland, Lars

doi:10.1007/bf00439095

Cited by 40 publications

(8 citation statements)

References 9 publications

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“…Platelet monoaminooxidase (MAO) activity was also found to be lower in some studies (Oreland, 1980), recovering its activity after 4 weeks of abstinence (Takahashi, 1976). Post-mortem investiga-tion demonstrated also decreased MAO activity in the brain of alcoholic suicides (Got#ries, 1975), although there are controversies in this field regarding both MAO activity (Wiberg, 1977) and 5-HT concentration of the brain (Cochran, 1976).…”

Section: Introductionmentioning

confidence: 95%

Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence

Bánki¹

1981

J. Neural Transmission

103

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Cerebrospinal fluid 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and tryptophan (TRY) were measured in 36 female patients with alcohol dependence defined by strict operational criteria. Results were compared with a control group of 32 women hospitalized in a neurological unit for peripheral diseases. Several disorders presumably interfering with monoamine metabolism were excluded and diet, psychomotor activity, diurnal variation, nutritional state and similar nonspecific variables controlled in both groups. Only 5-HIAA was found to be decreased in development patients as compared to controls. Since 5-HIAA--but neither HVA nor TRY--correlated with body height in both groups, we eliminated its effect by analysis of covariance: as a result 5-HIAA difference became statistically significant but the other two biochemical measures remained unchanged. A multivariate regression analysis with five independent clinical variables (body height, age, weight, years of alcohol abuse and days of abstinence) yielded significant determination coefficient R2 only for 5-HIAA. Regarding its components only body height and days of abstinence proved to be significantly correlated with 5-HIAA. Severity of withdrawal symptoms assessed on a rating scale in 14 patients with 4 days or less of abstinence correlated marginally with HVA but not with 5-HIAA. This latter metabolite decreased only in patients with 5 days or more of abstinence; the difference between 5-HIAA levels of short-term and long-term abstinence subgroups was statistically highly significant.

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Section: Introductionmentioning

confidence: 95%

Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence

Bánki¹

1981

J. Neural Transmission

103

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“…Wiberg et al have also reported that chronic ethanol treatment in rats did not alter brain MAO activity (19).…”

Section: Discussionmentioning

confidence: 96%

Effects of ethanol on catecholamine levels and related enzyme activities in different brain regions of rats.

Yamanaka

Egashira

1982

Jpn.J.Pharmacol

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Abstract-The effects of ethanol on the contents of norepinephrine (NE) and dopamine (DA) and the activities of related enzymes in the various regions of rat brains with different doses and mode of administration of ethanol were investigated. In acute ethanol intoxication, steady-state levels of NE were not altered. Continuous ethanol intoxication, however, significantly reduced NE contents and tended to decrease the activity of dopamine-Q-hydroxylase in the hippocampus. The decrease in NE con tents became more significant during ethanol withdrawal, especially in the medulla oblongata and the striatum. DA contents were increased in the brain-stem region in all ethanol-treated rats. The increase in DA contents correlated with the increase in tyrosine hydroxylase activity. The present data suggest that the dopaminergic system may contribute to the develop ment of physical dependence on ethanol.

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“…The early demonstration of diminished MAO activity in brains of alcoholic suicide victims [88], and the more recent work on human brain MAO activity by Oreland et al [89], gener ated speculation as to whether the lower MAO activity in brain tissue from alcoholics was a result of alcohol abuse, or an inherent characteristic of the individual. Studies of brain MAO activity in rats fed ethanol for up to 34 weeks indicated that ethanol produced little change in the brain MAO activity [90]. MAO activity was also unaltered in brains of mice made physically dependent on ethanol [91].…”

Section: Ac Activity After Chronic Ethanol Treatmentmentioning

confidence: 99%

“…As described above, chronic ethanol in gestion was reported not to alter brain MAO activity [90,91], However, the selective in vitro action of ethanol on MAO-B suggests that changes may occur only in one form of the brain enzyme after chronic ethanol treat ment, and this possibility should be investi gated in more detail.…”

Section: Effect Of Ethanol On Amine Oxidasementioning

confidence: 99%

Effects of Ethanol on the Activity of Brain Enzymes

Tabakoff

Hoffman

Liljequist³

1987

Enzyme

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Ethanol alters, in a selective manner, the activity of several membrane-bound enzymes in the central nervous system (CNS) which are important for neuronal transmission of information. Ethanol inhibits Na^+/K^+-transporting ATPase activity, while adenylate cyclase (AC) activity is stimulated by ethanol added in vitro. Ethanol’s effects on AC activity are mediated primarily via effects on proteins that regulate AC activity. Ethanol has selective effects on monoamine oxidase activity, in that the B form of the enzyme is more sensitive to inhibition by ethanol added in vitro. The selective effects of ethanol on different membranebound CNS enzymes may result from differing membrane lipid microenvironments of the enzymes, or from differences in the enzyme proteins per se.

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Brain monoamine oxidase activity after chronic ethanol treatment of rats

Cited by 40 publications

References 9 publications

Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence

Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence

Effects of ethanol on catecholamine levels and related enzyme activities in different brain regions of rats.

Effects of Ethanol on the Activity of Brain Enzymes

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