Brain metastasis from cervical carcinoma

Abstract

The aim of this study was to describe the features of patients with brain metastasis from cervical cancer. Twelve patients with brain metastasis from cervical cancer were identified. Information regarding symptoms, treatment, and survival was analyzed. The incidence of brain metastasis in our population was 0.77%. Median patient age at initial diagnosis of cervical cancer was 43.5 years (range 29-57 years) compared with 44.5 years (range 31-58 years) at identification of brain metastasis. Six patients had FIGO stage IB disease; three had stage IIB disease; and one each had stage IIIA, IIIB, and IVB disease. The median interval from diagnosis of cervical cancer to identification of brain metastasis was 17.5 months (range 1.1-96.1 months). All but one patient presented with neurologic symptoms. Eight patients received whole-brain irradiation and steroids, three received steroids alone, and one underwent surgery, followed by irradiation. All the patients who received whole-brain irradiation experienced improvement in their symptoms. Median survival from diagnosis of brain metastasis to death was 2.3 months (range 0.3-7.9 months). Five patients who received chemotherapy after brain irradiation had a median survival of 4.4 months compared to 0.9 months for those who received no additional treatment after brain irradiation (P= .016). Most patients with brain metastasis from cervical cancer presented with neurologic sequelae. Brain irradiation improved these symptoms. Survival after diagnosis of brain metastasis was poor; however, patients who received chemotherapy after brain irradiation appeared to have improved survival.

The impact of the stage and tumor size on rare brain metastasis of cervical cancer

“…Ikeda et al (7) reported that the initial stage was IIB in four of eight patients with brain metastasis from uterine cervical cancer. In a series of twelve cases from Chura et al (3), nine patients were stage IIB or below, while three patients were higher than stage IIB. In our study, four cases had an initial stage higher than IIB and eleven patients were stage IIB or below.…”

“…However, it is a rare development in uterine cervical cancer, with an incidence rate of only 0.4% to 1.2% (3,4,7,16). Recently, brain metastasis has been seen more frequently.…”

“…Despite the fact that metastatic brain tumors are said to constitute up to 50% of adult brain tumors, those arising from cervical cancer are a rare event, with an incidence rate between 0.4 to 1.2% among cervical cancer cases (3,4,7,13). Therefore, there are only case reports or small case series related to these rare metastases in the english medical literature (10)(11)(12)(15)(16)(17).…”

Combination of Abducens Nerve Palsy and Ipsilateral Postganglionic Horner Syndrome as an Initial Manifestation of Uterine Cervical Cancer

“…1) (20,21). On the other hand, uterine cervical cancer with brain metastasis is rare with an incidence of 0.44-1.18% (22)(23)(24), and there are no reports of intra-cavernous metastasis. Here, we describe a case presenting with this combination symptoms as an initial manifestation of uterine cervical cancer.…”

Squamous Cell Carcinoma of Vaginal Vault with Liver, Adrenal and Brain Metastases: Report of an Uncommon Presentation

“…Adrenal metastases from primary SqCC cervix are rarely reported in literature [4] while brain metastases are extremely rare [1,5,6] with an incidence of 0.4%-1.2% [7][8][9][10]. Similarly, SqCC of vagina most commonly metastasizes to lung, bone and least commonly to liver while adrenal and brain metastases are rarely heard of [11].…”