Brain metallothionein labelled with 109‐cd and 59‐fe and its involvement in iron homeostasis∗

In order to study the metabolism of mercury (Hg), its affinity to metallothionein (MT), and its influence on levels of the essential metals copper and zinc in the brain tissue of rats exposed to elemental mercury (HgO) vapor was investigated. The major findings were: 1. After long-term exposure, about 40% of mercury was found in the brain water-soluble phase (supernatant); 2. In brain supernatant, about 80% of Hg was found in the range of low-molecular-weight proteins; the MT-like protein Hg-Cu-Zn-thionein was isolated and partially characterized; 3. HgO vapor exposure resulted in increased tissue levels of essential Cu and Zn in addition to exogenous Hg; and 4. Experiments showed that HgO vapor exposure can induce the stimulation of rat brain MT synthesis.

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Interactions of mercury in rat brain

Falnoga

Kregar

Škreblin

et al. 1993

Biol Trace Elem Res

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Excitation functions for the production of 109Cd, 109In and 109Sn in proton bombardment of indium up to 200 MeV

Nortier

Mills

Steyn

1991

International Journal of Radiation Applications and Instrumenta

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Brain metallothionein labelled with 109‐cd and 59‐fe and its involvement in iron homeostasis∗

Cited by 2 publications

References 16 publications

Interactions of mercury in rat brain

Interactions of mercury in rat brain

Excitation functions for the production of 109Cd, 109In and 109Sn in proton bombardment of indium up to 200 MeV

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