Brain Metabolite Levels Assessed by Lactate-Edited MR Spectroscopy in Premature Neonates with and without Pentobarbital Sedation

Wang, Z.J.; Vigneron, Daniel B.; Miller, Steven P.; Mukherjee, Pratik; Charlton, Natalie N.; Lu, Ying; Barkovich, A. James

doi:10.3174/ajnr.a0912

Cited by 20 publications

(11 citation statements)

References 21 publications

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“…Unlike previously reported (21), the metabolite levels for patients with and without sedation did not differ. It is possible that with large amount of data, that variability is not significant.…”

Section: Discussioncontrasting

confidence: 93%

MR spectroscopy of normative premature newborns

Bonifacio

Charlton

et al. 2011

Magnetic Resonance Imaging

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Purpose To establish normative metabolite ratios throughout the newborn brain using 3D MR Spectroscopic Imaging. Materials and Methods MRI and MRSI have been valuable tools for assessing normal and abnormal neuronal maturation for newborns. In this study, we performed whole brain 3D MRSI in addition to comprehensive anatomic and other functional imaging methods to examine maturation. 55 newborn subjects (28.4 ± 2.6 weeks post-conceptional age at birth, 34.1 ± 3.1 weeks post-conception age at scan, 32 males and 23 females) had high quality MRSI studies (104 exams) and normal neurodevelopmental outcome (NMS=0, MDI>85) at age 12 months. Results The NAA to Cho ratio increased significantly with age for all regions. Lac to NAA ratio decreased significantly with age in the regions of thalamus, basal ganglia, cortical spinal tract, and parietal white matter, and showed a decreasing trend in the other regions. Conclusion Brain metabolites can be obtained through in vivo 3D MRSI and used to monitor newborn brain maturation.

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Section: Discussioncontrasting

confidence: 93%

MR spectroscopy of normative premature newborns

Bonifacio

Charlton

et al. 2011

Magnetic Resonance Imaging

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“…The current work builds on the BASING J-difference lactate editing work performed at 1.5T (5,15,16) and addresses the complicating factor of coupling anomalies at 3T. BASING has been applied to proton spectroscopy at 3T with the goal of eliminating the anomalous lactate coupling problem in a single-shot scheme not designed to detect lactate in the presence of lipids (11).…”

Section: Discussionmentioning

confidence: 99%

“…The 3T scanner presents a challenge in that chemical shift effects due to limited radiofrequency (RF) bandwidth in slice selective pulses can result in loss of lactate signal (11–14). The current study extends the use of the dual BASING technique for lactate editing (5,15,16) to 3T and addresses the chemical shift effect as well.…”

mentioning

confidence: 96%

J‐difference lactate editing at 3.0 Tesla in the presence of strong lipids

Smith

Koutcher

Zakian

2008

Magnetic Resonance Imaging

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Purpose: To implement in vivo detection of lactate in the presence of lipids by proton magnetic resonance spectroscopy at a 3 Tesla (T) field strength for potential applications in human tumors outside of the brain. Materials and Methods:The BASING J-difference sequence was implemented in the presence of high lipid concentrations in phantoms and in vivo at 3 Tesla. Results:The effectiveness of the lactate editing scheme is demonstrated in phantoms containing both lactate and lipids and in vivo in ischemic induced human muscle. Conclusion:The ability of the BASING J-difference technique to detect lactate in the presence of strong lipid signals outside the brain at 3T is feasible. This robust technique should permit noninvasive lactate measurements in human tumors to investigate its potential as a prognostic indicator.

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“…Since then only a few 1 H MRS studies has been performed directly on human fetuses. Most data were obtained ex utero from premature neonates, and thus did not reflect the physiologic maturation process of the cerebral structures occurring during pregnancy (Wang et al, 2008). In this study, in vivo 1 H MRS of human fetal brain was performed in the third trimester of normal pregnancy (Heerschap and van den Berg, 1994).…”

Section: Clinical Magnetic Resonance Imaging Studies Of the Fetal Brainmentioning

confidence: 99%

MRI-based methods to detect placental and fetal brain abnormalities in utero

Girardi

2016

Journal of Reproductive Immunology

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Brain Metabolite Levels Assessed by Lactate-Edited MR Spectroscopy in Premature Neonates with and without Pentobarbital Sedation

Cited by 20 publications

References 21 publications

MR spectroscopy of normative premature newborns

MR spectroscopy of normative premature newborns

J‐difference lactate editing at 3.0 Tesla in the presence of strong lipids

MRI-based methods to detect placental and fetal brain abnormalities in utero

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