Brain Metabolic Dysfunction in Capgras Delusion During Alzheimer’s Disease

Jedidi, Haroun; Daury, Noémy; Bahri, Mohamed Ali; Collette, Fabienne; Feyers, Dorothée; Bastin, Christine; Maquet, Pierre; Salmon, Eric

doi:10.1177/1533317513495105

Cited by 13 publications

(6 citation statements)

References 65 publications

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“…Patchitt & Shergill interpret two psychiatric syndromes, the Capgras delusion and the Fregoli syndrome, in light of the integrative memory model. We have reported the case of a patient with probable Alzheimer's disease who presented symptoms of Capgras syndrome with regard to her husband (Jedidi et al 2015). Compared to other probable Alzheimer's disease patients without any misidentification symptoms, the patient showed decreased metabolism in the posterior cingulate gyrus/precuneus and the dorsomedial prefrontal cortex.…”

Section: Representation Core Systemsmentioning

confidence: 99%

Interactions with the integrative memory model

et al. 2019

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The integrative memory model formalizes a new conceptualization of memory in which interactions between representations and cognitive operations within large-scale cerebral networks generate subjective memory feelings. Such interactions allow to explain the complexity of memory expressions, such as the existence of multiples sources for familiarity and recollection feelings and the fact that expectations determine how one recognizes previously encountered information.

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Section: Representation Core Systemsmentioning

confidence: 99%

Interactions with the integrative memory model

et al. 2019

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“…Our results using VBM also implicated larger clusters in the right frontal orbital gyri, and in the left olfactory gyrus. Since the localization of reported gray matter lesions varies greatly across different studies, even when VBM has been used ( Jedidi et al, 2015 ), the need for further studies is warranted. In this study we analyzed the impact of the patient GM lesion on the nodes of the face sensitive neural areas by calculating the overlap between the VBM identified lesions and previously published functional ROIs ( Julian et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Testing the connections within face processing circuitry in Capgras delusion with diffusion imaging tractography

Bobes

Góngora

Valdes

et al. 2016

NeuroImage: Clinical

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Although Capgras delusion (CD) patients are capable of recognizing familiar faces, they present a delusional belief that some relatives have been replaced by impostors. CD has been explained as a selective disruption of a pathway processing affective values of familiar faces. To test the integrity of connections within face processing circuitry, diffusion tensor imaging was performed in a CD patient and 10 age-matched controls. Voxel-based morphometry indicated gray matter damage in right frontal areas. Tractography was used to examine two important tracts of the face processing circuitry: the inferior fronto-occipital fasciculus (IFOF) and the inferior longitudinal (ILF). The superior longitudinal fasciculus (SLF) and commissural tracts were also assessed. CD patient did not differ from controls in the commissural fibers, or the SLF. Right and left ILF, and right IFOF were also equivalent to those of controls. However, the left IFOF was significantly reduced respect to controls, also showing a significant dissociation with the ILF, which represents a selective impairment in the fiber-tract connecting occipital and frontal areas. This suggests a possible involvement of the IFOF in affective processing of faces in typical observers and in covert recognition in some cases with prosopagnosia.

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“…We included this comparison in an effort to reveal impairments that are uniquely associated with CS, while aiming to control for other cognitive and behavioral effects that are associated with DLB more broadly (see Collerton et al, 2003 ; Metzler-Baddeley, 2007 ; Johns et al, 2009 , for review). This type of comparison seems particularly important when testing patients with neurodegenerative conditions, which are known to affect cognitive functioning more broadly than focal lesions (see Jedidi et al, 2013 for similar design in a single-case study on CS in Alzheimer’s disease). Although the results from the present single-case study clearly advance our understanding of the nature of person recognition impairments associated with CS, we recognize that further research will be needed to examine the extent to which they generalize to other CS patients with DLB and other etiologies.…”

Section: Discussionmentioning

confidence: 99%

Nature and extent of person recognition impairments associated with Capgras syndrome in Lewy body dementia

Fiacconi

Barkley

Finger

et al. 2014

Front. Hum. Neurosci.

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Patients with Capgras syndrome (CS) adopt the delusional belief that persons well-known to them have been replaced by an imposter. Several current theoretical models of CS attribute such misidentification problems to deficits in covert recognition processes related to the generation of appropriate affective autonomic signals. These models assume intact overt recognition processes for the imposter and, more broadly, for other individuals. As such, it has been suggested that CS could reflect the “mirror-image” of prosopagnosia. The purpose of the current study was to determine whether overt person recognition abilities are indeed always spared in CS. Furthermore, we examined whether CS might be associated with any impairments in overt affective judgments of facial expressions. We pursued these goals by studying a patient with Dementia with Lewy bodies (DLB) who showed clear signs of CS, and by comparing him to another patient with DLB who did not experience CS, as well as to a group of healthy control participants. Clinical magnetic resonance imaging scans revealed medial prefrontal cortex (mPFC) atrophy that appeared to be uniquely associated with the presence CS. We assessed overt person recognition with three fame recognition tasks, using faces, voices, and names as cues. We also included measures of confidence and probed pertinent semantic knowledge. In addition, participants rated the intensity of fearful facial expressions. We found that CS was associated with overt person recognition deficits when probed with faces and voices, but not with names. Critically, these deficits were not present in the DLB patient without CS. In addition, CS was associated with impairments in overt judgments of affect intensity. Taken together, our findings cast doubt on the traditional view that CS is the mirror-image of prosopagnosia and that it spares overt recognition abilities. These findings can still be accommodated by models of CS that emphasize deficits in autonomic responding, to the extent that the potential role of interoceptive awareness in overt judgments is taken into account.

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Brain Metabolic Dysfunction in Capgras Delusion During Alzheimer’s Disease

Cited by 13 publications

References 65 publications

Interactions with the integrative memory model

Interactions with the integrative memory model

Testing the connections within face processing circuitry in Capgras delusion with diffusion imaging tractography

Nature and extent of person recognition impairments associated with Capgras syndrome in Lewy body dementia

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