Brain-mapping projects using the common marmoset

Mitra, Partha P.

doi:10.1016/j.neures.2014.08.014

Cited by 89 publications

(83 citation statements)

References 27 publications

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“…In addition, the marmoset connectome project has been initiated in Japan (Okano and Mitra, 2014) which may allow us to compare rodents and primates in a more comprehensive manner once whole spectrum of data are collected. Such comparison will require careful functional mapping of brain regions in both rodents and primates.…”

Section: How Can We Move Forward To Deal With Cognitive Impairmentmentioning

confidence: 99%

Converging models of schizophrenia – Network alterations of prefrontal cortex underlying cognitive impairments

Sakurai

Gamo

Hikida

et al. 2015

Progress in Neurobiology

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The prefrontal cortex (PFC) and its connections with other brain areas are crucial for cognitive function. Cognitive impairments are one of the core symptoms associated with schizophrenia, and manifest even before the onset of the disorder. Altered neural networks involving PFC contribute to cognitive impairments in schizophrenia. Both genetic and environmental risk factors affect the development of the local circuitry within PFC as well as development of broader brain networks, and make the system vulnerable to further insults during adolescence, leading to the onset of the disorder in young adulthood. Since spared cognitive functions correlate with functional outcome and prognosis, a better understanding of the mechanisms underlying cognitive impairments will have important implications for novel therapeutics for schizophrenia focusing on cognitive functions. Multidisciplinary approaches, from basic neuroscience to clinical studies, are required to link molecules, circuitry, networks, and behavioral phenotypes. Close interactions among such fields by sharing a common language on connectomes, behavioral readouts, and other concepts are crucial for this goal.

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Section: How Can We Move Forward To Deal With Cognitive Impairmentmentioning

confidence: 99%

Converging models of schizophrenia – Network alterations of prefrontal cortex underlying cognitive impairments

Sakurai

Gamo

Hikida

et al. 2015

Progress in Neurobiology

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“…Macroscopic structural mapping of fiber tracts using diffusion tensor imaging (DTI) is not yet routinely performed in common laboratory animals. With improved resolution down to 50 µm 3 for ex vivo and 200 µm 3 for in vivo interrogations, this technique can be used in animal models such as the common marmoset 82 . In addition, recently developed tissue-clearing techniques such as Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging/Immunostaining/In situ hybridization-compatible Tissue-hYdrogel, (CLARITY) for mesoscale optical investigation, which renders the brain transparent in its native three-dimensional state, can be used to reveal morphological abnormalities in animal models 83 .…”

Section: The Pursuit Of Translatability: Aligning Preclinical To Clinmentioning

confidence: 99%

Modeling psychiatric disorders for developing effective treatments

Kaiser

Feng

2015

Nat Med

135

112

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The recent advance in identifying risk genes has provided an unprecedented opportunity for developing animal models for psychiatric disease research with the goal of attaining translational utility to ultimately develop novel treatments. However, at this early stage, successful translation has yet to be achieved. Here, we review recent advances in modeling psychiatric disease, discuss utility and limitations of animal models, and emphasize the importance of shifting from behavioral analysis to identifying neurophysiological defects, which are likely more conserved across species and thus increase translatability. Looking forward, we envision that preclinical research will align with clinical research to build a common framework of comparable neurobiological abnormalities and form subgroups of patients based on similar pathophysiology. Experimental neuroscience can then use animal models to discover mechanisms underlying distinct abnormalities and develop strategies for effective treatments.

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“…The first two articles summarize a large scale brain-mapping project using marmosets that has recently been reported (Okano and Mitra, 2015), and the characteristics of the marmoset in neuroscientific and anthropological studies from an evolutional point of view (Burkart and Finkenwirth, 2015).…”

Section: Q2mentioning

confidence: 99%