Brain lipoprotein lipase is responsive to nutritional and hormonal modulation

Gavin, Laurence A.; Cavalieri, Ralph R.; Moeller, Marie; McMahon, Francis A.; Castle, James N.; Gulli, Rocco

doi:10.1016/0026-0495(87)90124-7

Cited by 24 publications

(16 citation statements)

References 16 publications

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“…Results are expressed as mean±SEM. this is corrected with chronic insulin treatment ( 16). We were unable to reliably detect significant levels of LPL activity or immunoreactive protein in the brains of adult rats from control, diabetic, or insulin treated.…”

Section: 8±64 Neq/h-ng; P = Ns)mentioning

confidence: 63%

“…In the brain, LPL is thought to provide precursors for cell membrane biosynthesis, particularly during brain development. Gavin et al ( 16) reported a 45% decrease in brain LPL activity in young adult diabetic rats, that was corrected with chronic insulin treatment, suggesting that LPL may have other roles in the brain. In the present studies, we were unable to detect LPL activity or immunoreactive protein in the brain.…”

Section: Discussionmentioning

confidence: 99%

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Regulation of lipoprotein lipase in the diabetic rat.

Tavangar

Murata²,

Pedersen³

et al. 1992

J. Clin. Invest.

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Section: 8±64 Neq/h-ng; P = Ns)mentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Regulation of lipoprotein lipase in the diabetic rat.

Tavangar

Murata²,

Pedersen³

et al. 1992

J. Clin. Invest.

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“…Because diabetes has been associated with increased LPL expression in various tissues (19)(20)(21)(22), we would not have been surprised to discover an upregulation of placental LPL mRNA expression, but this was not the case. Also, we did not find any difference between the groups in the expression of LAL mRNA or in secretory phospholipase A2 group IIa mRNA (data not shown).…”

Section: Discussionmentioning

confidence: 99%

“…Other groups have presented studies suggesting that diabetes might increase the expression of lipase genes (e.g., HSL and LPL) in various tissues (19)(20)(21)(22)(23). Thus, we hypothesized that maternal diabetes affects the expression of lipase genes in placenta.…”

mentioning

confidence: 99%

Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression

Lindegaard

Damm

Mathiesen

et al. 2006

Journal of Lipid Research

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Maternal diabetes can cause fetal macrosomia and increased risk of obesity, diabetes, and cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid transport could be involved, the impact of maternal type 1 diabetes on molecular mechanisms for lipid transport in placenta is largely unknown. To examine whether maternal type 1 diabetes affects placental lipid metabolism, we measured lipids and mRNA expression of lipase-encoding genes in placentas from women with type 1 diabetes (n 5 27) and a control group (n 5 21). The placental triglyceride (TG) concentration and mRNA expression of endothelial lipase (EL) and hormone-sensitive lipase (HSL) were increased in placentas from women with diabetes. The differences were more pronounced in women with diabetes and suboptimal metabolic control than in women with diabetes and good metabolic control. Placental mRNA expression of lipoprotein lipase and lysosomal lipase were similar in women with diabetes and the control group. Immunohistochemistry showed EL protein in syncytiotrophoblasts facing the maternal blood and endothelial cells facing the fetal blood in placentas from both normal women and women with diabetes.These results suggest that maternal type 1 diabetes is associated with TG accumulation and increased EL and HSL gene expression in placenta and that optimal metabolic control reduces these effects.-Lindegaard, M. L. S., P. Damm, E. R. Mathiesen, and L. B. Nielsen. Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression.

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“…LPL is also present throughout the nervous system, including the brain, spinal cord, and peripheral nerve (4, 6, 10, 12, 14, 20, 23, 40, 57, 63, 78, 82, 85, 94). Compared to the numerous in vivo studies in humans, in various tissue culture systems, and in many animal models focusing on the tissue-specific functions of LPL in peripheral tissues (reviewed in 88), relatively limited studies have been published on the function of LPL in the brain and central nervous system (CNS).…”

Section: Introductionmentioning

confidence: 99%

Lipoprotein Lipase in the Brain and Nervous System

Wang

Eckel

2012

Annu. Rev. Nutr.

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Lipoprotein lipase (LPL) is rate limiting in the provision of triglyceride-rich lipoprotein-derived lipids into tissues. LPL is also present in the brain, where its function has remained elusive. Recent evidence implicates a role of LPL in the brain in two processes: (a) the regulation of energy balance and body weight and (b) cognition. Mice with neuron-specific deletion of LPL have increases in food intake that lead to obesity, and then reductions in energy expenditure that further contribute to and sustain the phenotype. In other mice with LPL deficiency rescued from neonatal lethality by somatic gene transfer wherein LPL in the brain remains absent, altered cognition ensues. Taking into consideration data that associate LPL mutations with Alzheimer’s disease, a role for LPL in learning and memory seems likely. Overall, the time is ripe for new insights into how LPL-mediated lipoprotein metabolism in the brain impacts CNS processes and systems biology.

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Brain lipoprotein lipase is responsive to nutritional and hormonal modulation

Cited by 24 publications

References 16 publications

Regulation of lipoprotein lipase in the diabetic rat.

Regulation of lipoprotein lipase in the diabetic rat.

Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression

Lipoprotein Lipase in the Brain and Nervous System

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