Brain lesions several years after eclampsia

Aukes, Annet M.; Groot, Jan Cees de; Aarnoudse, Jan G.; Zeeman, Gerda G.

doi:10.1016/j.ajog.2008.12.033

Cited by 68 publications

(43 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diagnostic imaging reveals that these WMLs can persist for years after the index pregnancy (22–24, 229). Counterintuitively, the pattern of distribution of WMLs associated with preeclampsia differs from that of Posterior Reversible Encephalopathy Syndrome (PRES).…”

Section: Cerebrovascular and Higher Function Neurological Consequencementioning

confidence: 99%

“…In the absence of the cardiovascular adaptations to pregnancy (Figure 1), the combination of an impaired BRS, sympathovagal imbalance, and pathogenic factors from the ischemic placenta advance the sequelae of life-threatening white matter lesions (22–24), cerebral edema and hemorrhaging (25–27) that can lead to executive dysfunction (28–30). Furthermore, PE establishes predispositions to anxiety (31–33), depression (34–36), and PTSD (37–42) in the gravid female, which are significantly correlated to low fetal birth weight, IUGR, and premature birth (32–36, 38).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia

2016

View full text Add to dashboard Cite

Preeclampsia (PE) is a form of gestational hypertension that complicates ~ 5 percent of pregnancies worldwide. Over 70 percent of the fatal cases of PE are attributed to cerebral edema, intracranial hemorrhage, and eclampsia. The etiology of PE originates from abnormal remodeling of the maternal spiral arteries, creating an ischemic placenta that releases factors that drive the pathophysiology. An initial neurological outcome of PE is the absence of the autonomically regulated cardiovascular adaptations to pregnancy. PE patients exhibit sympathetic overactivation, in comparison to both normotensive pregnant and hypertensive non-pregnant females. Moreover, PE diminishes baroreceptor reflex sensitivity (BRS) beyond that observed in healthy pregnancy. The absence of the cardiovascular adaptations to pregnancy, combined with sympathovagal imbalance and a blunted BRS leads to life-threatening neurological outcomes. Behaviorally, the increased incidences of maternal depression, anxiety, and post-traumatic stress disorder (PTSD) in PE are correlated to low fetal birth weight, intrauterine growth restriction (IUGR) and premature birth. This review addresses these neurological consequences of PE that present in the gravid female both during and after the index pregnancy.

show abstract

Section: Cerebrovascular and Higher Function Neurological Consequencementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia

2016

View full text Add to dashboard Cite

show abstract

“…However, there is evidence that long-term changes may occur within the brains of women with a history of preeclampsia. In long-term studies of women with a history of preeclampsia or eclampsia, 34–37% and 41% respectively were found to have white matter lesions (WML) on MRI imaging, a significantly higher rate and volume than women with a history of a normotensive pregnancy (17–21%) [6,70,71•]. WML are radiographic findings of hyperintense regions located within the hemispheric white matter on T2 weighted MRI images of the brain [72].…”

Section: White Matter Lesionsmentioning

confidence: 99%

Cerebrovascular Dysfunction in Preeclamptic Pregnancies

Hammer

Cipolla

2015

Curr Hypertens Rep

View full text Add to dashboard Cite

Preeclampsia is a hypertensive, multi-system disorder of pregnancy that affects several organ systems, including the maternal brain. Cerebrovascular dysfunction during preeclampsia can lead to cerebral edema, seizures, stroke and potentially maternal mortality. This review will discuss the effects of preeclampsia on the cerebrovasculature that may adversely affect the maternal brain, including cerebral blood flow (CBF) autoregulation and blood-brain barrier disruption, and the resultant clinical outcomes including posterior reversible encephalopathy syndrome (PRES) and maternal stroke. Potential long-term cognitive outcomes of preeclampsia and the role of the cerebrovasculature are also reviewed.

show abstract

“…Two studies have suggested that preeclampsia and eclampsia are associated with self-reported worsening of cognitive function [122] and memory performance [123], but they did not systematically examine the association between hypertensive pregnancy disorders and domain-specific cognitive functioning later in life.…”

Section: Reviewmentioning

confidence: 99%

Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause

Miller

Garovic

Kantarci³

et al. 2013

Biol sex dif

View full text Add to dashboard Cite

Understanding the biology of sex differences is integral to personalized medicine. Cardiovascular disease and cognitive decline are two related conditions, with distinct sex differences in morbidity and clinical manifestations, response to treatments, and mortality. Although mortality from all-cause cardiovascular diseases has declined in women over the past five years, due in part to increased educational campaigns regarding the recognition of symptoms and application of treatment guidelines, the mortality in women still exceeds that of men. The physiological basis for these differences requires further research, with particular attention to two physiological conditions which are unique to women and associated with hormonal changes: pregnancy and menopause. Both conditions have the potential to impact life-long cardiovascular risk, including cerebrovascular function and cognition in women. This review draws on epidemiological, translational, clinical, and basic science studies to assess the impact of hypertensive pregnancy disorders on cardiovascular disease and cognitive function later in life, and examines the effects of post-menopausal hormone treatments on cardiovascular risk and cognition in midlife women. We suggest that hypertensive pregnancy disorders and menopause activate vascular components, i.e., vascular endothelium and blood elements, including platelets and leukocytes, to release cell-membrane derived microvesicles that are potential mediators of changes in cerebral blood flow, and may ultimately affect cognition in women as they age. Research into specific sex differences for these disease processes with attention to an individual’s sex chromosomal complement and hormonal status is important and timely.

show abstract

Brain lesions several years after eclampsia

Cited by 68 publications

References 30 publications

Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia

Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia

Cerebrovascular Dysfunction in Preeclamptic Pregnancies

Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause

Contact Info

Product

Resources

About