Brain laterality evaluated by F-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders

Abstract

Background and rationaleAutism spectrum disorder (ASD) is a neuropsychiatric disorder that has no curative treatment. Little is known about the brain laterality in patients with ASD. F-18 fluorodeoxyglucose positron emission computed tomography (F-18 FDG PET/CT) is a neuroimaging technique that is suitable for ASD owing to its ability to detect whole brain functional abnormalities in a short time and is feasible in ASD patients. The purpose of this study was to evaluate brain laterality using F-18 FDG PET/CT in patients with high-functioning ASD.Materials and methodsThis case-control study recruited eight ASD patients who met the DSM-5 criteria, the recorded data of eight controls matched for age, sex, and handedness were also enrolled. The resting state of brain glucose metabolism in the regions of interest (ROIs) was analyzed using the Q.Brain software. Brain glucose metabolism and laterality index in each ROI of ASD patients were compared with those of the controls. The pattern of brain metabolism was analyzed using visual analysis and is reported in the data description.ResultsThe ASD group’s overall brain glucose metabolism was lower than that of the control group in both the left and right hemispheres, with mean differences of 1.54 and 1.21, respectively. We found statistically lower mean glucose metabolism for ASD patients than controls in the left prefrontal lateral (Z = 1.96, p = 0.049). The left laterality index was found in nine ROIs for ASD and 11 ROIs for the control. The left laterality index in the ASD group was significantly lower than that in the control group in the prefrontal lateral (Z = 2.52, p = 0.012), precuneus (Z = 2.10, p = 0.036), and parietal inferior (Z = 1.96, p = 0.049) regions.ConclusionIndividuals with ASD have lower brain glucose metabolism than control. In addition, the number of ROIs for left laterality index in the ASD group was lower than control. Left laterality defects may be one of the causes of ASD. This knowledge can be useful in the treatment of ASD by increasing the left-brain metabolism. This trial was registered in the Thai Clinical Trials Registry (TCTR20210705005).

Anodal transcranial direct‐current stimulation and non‐verbal intelligence in autism spectrum disorder: A randomized controlled trial

“…26 metabolism was found in the LDLPFC of individuals with ASD than in a control group. 27 Prefrontal tDCS studies report increased resting-state functional connectivity 28 and network flexibility, particularly interhemispheric connectivity in the alpha frequency band. 29 Improvements in general intelligence and executive function subtests have been associated with LDLPFC tDCS, 5 potentially explaining the observed increase in TONI-IV index scores.…”

“…Hypoconnectivity is observed in the left lateral and medial prefrontal cortex of high‐functioning individuals with ASD 26 . Lower glucose metabolism was found in the LDLPFC of individuals with ASD than in a control group 27 . Prefrontal tDCS studies report increased resting‐state functional connectivity 28 and network flexibility, particularly interhemispheric connectivity in the alpha frequency band 29 .…”