Brain Injury Scores of Neonates with Complex Congenital Heart Disease

Kuhn, Viktoria; Carpenter, L. J.; Tague, Lauren; Donofrio, Tom M.; Murnick, Jonathan; Zurakowski, David; Axt-Fliedner, R; Jonas, A.; Limperopoulos, Catherine; Yerebakan, Can

doi:10.1055/s-0039-1679081

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kuhn et al examined the impact of surgical and therapeutic risk factors on pre- and postoperative brain MRI findings in 48 neonates with complex CHD (HLHS and dextro-transposition of the great arteries) using a brain injury score. The preoperative brain MRI was abnormal in 27 of 48 neonates (56%) with no significant differences between the two groups with regard to the total injury score (p = 0.47) 97 . This led to a supposition that the pathological processes had a prenatal origin, leading to poor later neurodevelopment in CHD patients.…”

Section: Reviewmentioning

confidence: 83%

New Aspects in the Diagnosis and Therapy of Fetal Hypoplastic Left Heart Syndrome

Graupner

Enzensberger

Axt-Fliedner

2019

Geburtshilfe Frauenheilkd

View full text Add to dashboard Cite

Fetal hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease with a lethal prognosis without postnatal therapeutic intervention or surgery. The aim of this article is to give a brief overview of new findings in the field of prenatal diagnosis and the therapy of HLHS. As cardiac output in HLHS children depends on the right ventricle (RV), prenatal assessment of fetal RV function is of interest to predict poor functional RV status before the RV becomes the systemic ventricle. Prenatal cardiac interventions such as fetal aortic valvuloplasty and non-invasive procedures such as maternal hyperoxygenation seem to be promising treatment options but will need to be evaluated with regard to long-term outcomes. Novel approaches such as stem cell therapy or neuroprotection provide important clues about the complexity of the disease. New aspects in diagnostics and therapy of HLHS show the potential of a targeted prenatal treatment planning. This could be used to optimize parental counseling as well as pre- and postnatal management of affected children.

show abstract

Section: Reviewmentioning

confidence: 83%