Brain imaging correlates of recovered swallowing after dysphagic stroke: A fMRI and DWI study

Mihai, Paul Glad; Otto, Mareile; Domín, Martin; Platz, Thomas; Hamdy, Shaheen; Lotze, Martín

doi:10.1016/j.nicl.2016.05.006

Cited by 50 publications

(49 citation statements)

References 57 publications

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“…Finally, when lesions of the pyramidal tract were more severe, recovered swallowing appeared to be associated with asymmetric activation of the ipsilesional anterior cerebellum. Taken together, our data support a role for increased contralesional somatosensory resources and ipsilesional anterior cerebellum feed forward loops for recovered swallowing after dysphagia following stroke' (Mihai et al, 2016).…”

supporting

confidence: 65%

Functional Adaptation of Oromotor Functions and Aging: A Focused Review of the Evidence From Brain Neuroimaging Research

Lin

2020

Front. Aging Neurosci.

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Practice makes perfect" is a principle widely applied when one is acquiring a new sensorimotor skill to cope with challenges from a new environment. In terms of oral healthcare, the traditional view holds that restoring decayed structures is one of the primary aims of treatment. This assumes that the patient's oromotor functions would be recovered back to normal levels after the restoration. However, in older patients, such a structural-functional coupling after dental treatment shows a great degree of individual variations. For example, after prosthodontic treatment, some patients would adapt themselves quickly to the new dentures, while others would not. In this Focused Review, I argue that the functional aspects of adaptation-which would be predominantly associated with the brain mechanisms of cognitive processing and motor learning-play a critical role in the individual differences in the adaptive behaviors of oromotor functions. This thesis is critical to geriatric oral healthcare since the variation in the capacity of cognitive processing and motor learning is critically associated with aging. In this review, (a) the association between aging and the brain-stomatognathic axis will be introduced; (b) the brain mechanisms underlying the association between aging, compensatory behavior, and motor learning will be briefly summarized; (c) the neuroimaging evidence that suggests the role of cognitive processing and motor learning in oromotor functions will be summarized, and critically, the brain mechanisms underlying mastication and swallowing in older people will be discussed; and (d) based on the current knowledge, an experimental framework for investigating the association between aging and the functional adaptation of oromotor functions will be proposed. Finally, I will comment on the practical implications of this framework and postulate questions open for future research.

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supporting

confidence: 65%

Functional Adaptation of Oromotor Functions and Aging: A Focused Review of the Evidence From Brain Neuroimaging Research

Lin

2020

Front. Aging Neurosci.

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“…The present study was performed in an ER unit that does not keep severely ill patients; these patients are referred to intensive care units. Therefore, patients with posterior cerebral artery infarction with brainstem involvement, who usually exhibit more severe clinical features and greater swallowing impairment 28,29 , do not remain in the ER. This fact may explain why, in the present study, the group with the worst swallowing function (ASHA1) had greater impairment of the anterior cerebral circulatory system.…”

Section: Discussionmentioning

confidence: 99%

Clinical swallowing prognostic indicators in patients with acute ischemic stroke

Leite

Sassi

Medeiros

et al. 2019

Arq. Neuro-Psiquiatr.

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A swallowing disorder is present in more than 50% of patients with acute stroke. Objective To identify clinical prognostic indicators of the swallowing function in a population with acute ischemic stroke and to determine prioritization indicators for swallowing rehabilitation. Methods Participants were adults admitted to the emergency room who were diagnosed with acute ischemic stroke. Data gathering involved a swallowing assessment to determine the functional level of swallowing (American Speech-Language-Hearing Association National Outcome Measurement System – ASHA NOMS) and the verification of demographic and clinical variables. Results The study sample included 295 patients. For analysis purposes, patients were grouped as follows: ASHA NOMS levels 1 and 2 – ASHA1 (n = 51); levels 3, 4 and 5 – ASHA2 (n = 96); levels 6 and 7 – ASHA3 (n = 148). Statistical analyses indicated that patients who presented a poorer swallowing function (ASHA1) were older (age ≥ 70 years); had anterior circulation infarct; had lower scores on the Glasgow Coma Scale (GCS ≤ 14 points); took longer to initiate swallowing rehabilitation; had longer hospital stays; made more use of alternative feeding methods; needed more sessions of swallowing rehabilitation to remove alternate feeding methods; took longer to return to oral feeding and had poorer outcomes (fewer individuals discharged from swallowing rehabilitation sessions and increased mortality). Conclusion Patients with acute ischemic stroke, admitted to the emergency room, aged ≥ 70 years, score on the GCS ≤ 14, anterior circulation infarct and dementia should be prioritized for swallowing assessment and rehabilitation.

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“…The primary objective will be to measure maximum bite force and bite force fatigue over a time period of 22 months in nusinersen treated and untreated SMA patients. In order to provide a better overview of the overall oral function, several additional objectives will be pursued, including the measurement of tongue pressure and fatigue, maximum mouth opening, and swallowing impairment based on the Dysphagia Score by Bogenhausen (34,35).…”

Section: Study Design For a Validation Of The Approachmentioning

confidence: 99%

The Maximum Bite Force for Treatment Evaluation in Severely Affected Adult SMA Patients—Protocol for a Longitudinal Study

et al. 2020

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Spinal muscular atrophy (SMA) is a severe neuromuscular disorder characterized by the degeneration of motor neurons in the spinal cord, and comprises a broad clinical spectrum. With the advent of new therapies (e.g., Nusinersen) for patients of all ages and disease stages, sensitive clinical measures are needed to detect slight changes in muscle force even in immobilized, severely affected patients often unable to move limbs. As for these patients, well-established outcome scales set out to evaluate motor function do not work properly, we propose measurement of maximum bite force which is able to detect subtle changes of bulbar function. Requirements for this approach are mentioned, challenges are discussed, and first insights from a pilot study are presented. Finally, a study design is proposed to evaluate the measurement of maximum bite force during the follow up of SMA patients with and without a disease modifying therapy.

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Brain imaging correlates of recovered swallowing after dysphagic stroke: A fMRI and DWI study

Cited by 50 publications

References 57 publications

Functional Adaptation of Oromotor Functions and Aging: A Focused Review of the Evidence From Brain Neuroimaging Research

Functional Adaptation of Oromotor Functions and Aging: A Focused Review of the Evidence From Brain Neuroimaging Research

Clinical swallowing prognostic indicators in patients with acute ischemic stroke

The Maximum Bite Force for Treatment Evaluation in Severely Affected Adult SMA Patients—Protocol for a Longitudinal Study

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