Brain Imaging Abnormalities in Mental Disorders of Late Life

Gs, Zubenko; Sullivan, Patrick F.; Jp, Nelson; Sh, Belle; Fj, Huff; Gl, Wolf

doi:10.1001/archneur.1990.00530100075016

Cited by 139 publications

(53 citation statements)

References 47 publications

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“…We found that both crude and adjusted risks of vascular depression were associated with age and late-onset depressive illness. These results validate earlier studies showing a link between vascular changes and late-onset depression (10)(11)(12)(13)(14). Lower risk of a family history of mental disorder or suicide and higher risk of anhedonia and functional disability were evident among patients with vascular depression, although chance cannot be ruled out as the explanation.…”

Section: Discussionsupporting

confidence: 92%

MRI-defined vascular depression

Krishnan

Hays²,

Blazer³

1997

AJP

665

101

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Section: Discussionsupporting

confidence: 92%

MRI-defined vascular depression

Krishnan

Hays²,

Blazer³

1997

AJP

665

101

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“…5 The previous investigation included all 128 elderly patients admitted between 1985 and 1988 to two inpatient units of the Geriatric Health Services of the Western Psychiatric Institute and Clinic who typically met DSM-III 29 or DSM-IIIR 30 criteria for dementia or major depression; the patients were evaluated by boardcertified psychiatrists and internists, with brain imaging included as a part of the usual diagnostic evaluation. The previous investigation also included 44 neurologically healthy elderly controls, chiefly caregivers and family members of patients with the clinical diagnosis of dementia, provided by the Alzheimer's Disease Research Center of the University of Pittsburgh, where they had been evaluated by board-certified psychiatrists and neurologists.…”

Section: Methodsmentioning

confidence: 99%

“…9 - 11 This suggestion has been confirmed in a recent study of the MRI head scans of 128 elderly psychiatric inpatients and 44 neurologically healthy volunteers. 5 Controlling for the independent effects of age and sex, both subcortical white matter hyperintensities and cortical infarcts were more common among the patients with major depression than among the volunteers. Moreover, these studies suggest that MRI may have a role in the differential diagnosis of late-life mental disorders and may carry prognostic significance and that structural brain changes may participate in the pathogenesis of idiopathic major depression in this age group.…”

mentioning

confidence: 99%

Risk factors for white matter changes detected by magnetic resonance imaging in the elderly.

Sullivan

Pary

Telang

et al. 1990

Stroke

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We found increased age (p=0.001) and history or evidence of stroke (p=0.016) to be significant independent multivariate predictors of the presence and severity of leukoencephalopathy on magnetic resonance imaging brain scans in a mixed population of 35 elderly psychiatric patients and 25 neurologically healthy elderly volunteers. These results suggest that subcortical ischemia, as well as age-related changes that may not be vascular in origin, contribute to the emergence of peri ventricular and other deep white matter hyperintensities that are commonly seen on the magnetic resonance imaging brain scans of older adults.

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“…De 1990 a 1995, vários autores 9,16,[20][21][22][23][24][25] buscaram saber quais os idosos deprimidos que apresentam hipersinais à ressonância magnética. Embora os estudos apresentassem resultados conflitantes, algumas características se repetiam.…”

Section: Discussionunclassified

Hipersinais subcorticais no exame de ressonância magnética: comparação entre idosos deprimidos e idosos normais

Novaretti

Marcolin

Meira

et al. 2001

Arq. Neuro-Psiquiatr.

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RESUMO É relatado em alguns estudos que idosos deprimidos apresentam maior frequência de hipersinais ao exame de ressonância magnética do que controles normais. No entanto os indivíduos estudados tinham fatores de risco para doenças cerebrovasculares. Este estudo analisou pacientes com história de depressão maior e indivíduos controles compatíveis, excluindo-se fatores de risco cerebrovasculares, com o objetivo de determinar se indivíduos deprimidos apresentam maior frequência de hipersinais em substância branca e outras lesões. Avaliamos a prevalência e a severidade dos hipersinais à ressonância magnética de encéfalo em 30 pacientes idosos deprimidos e 20 controles pareados para a idade. Hipersinais de substância branca profunda, hipersinais periventriculares e hipersinais em substância cinzenta subcortical foram classificados em escala padrão 0-3, por dois radiologistas que desconheciam o diagnóstico clínico. Não foram encontradas diferenças significativas entre os grupos para hipersinais subcorticais. Estes achados sugerem que os fatores de risco cerebrovasculares provavelmente medeiam a relação entre depressão e hipersinais, encontrada em estudos anteriores.PALAVRAS-CHAVE: demência vascular, ressonância magnética nuclear, depressão, idoso. Subcortical hyperintensities on magnetic resonance imaging: a comparison of normal and depressed elderly subjectsABSTRACT -Previous studies reported that depressed subjects had more signal hyperintensities on magnetic resonance imaging scans than control subjects, but the subjects had cerebrovascular disease risk factors. This study used subjects with a history of major depression and matched comparison subjects, screened to exclude cerebrovascular risk factors, to determine whether depressed subjects had more white matter hyperintensities and other lesions. We evaluated the prevalence and severity of MRI signal hyperintensities in 30 elderly depressed patients and 20 controls matched for age. Deep matter hyperintensities, periventricular hyperintensities and subcortical gray hyperintensities were rated on a standard 0-3 scale by two radiologists blind to clinical diagnosis. No significant differences were found between groups for the presence of subcortical gray matter, deep white matter and periventricular hyperintensities. These findings suggest that cerebrovascular disease risk factors most likely mediated the relationship between depression and hyperintensities in previous studies.KEY WORDS: vascular dementia, magnetic resonance imaging, depression, elderly. Existem poucas características clínicas que distinguem os idosos que apresentam depressão iniciada precocemente daqueles com depressão de início tardio 1-4 indicando que, se houver fatores de risco associados à idade, eles não podem ser identificados apenas por estas características. O risco familiar para depressão declina com o envelhecimento e os transtornos de início tardio podem, mais frequentemente, ser consequência de doenças cuja incidência aumenta com a idade como as doenças vasculares e neurodegenerativas...

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Brain Imaging Abnormalities in Mental Disorders of Late Life

Cited by 139 publications

References 47 publications

MRI-defined vascular depression

MRI-defined vascular depression

Risk factors for white matter changes detected by magnetic resonance imaging in the elderly.

Hipersinais subcorticais no exame de ressonância magnética: comparação entre idosos deprimidos e idosos normais

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