Brain hypometabolism of glucose in anorexia nervosa: A PET scan study

Delvenne, Véronique; Lotstra, Françoise; Goldman, Serge; Biver, Françoise; Maertelaer, Viviane De; Appelboom-Fondu, J.; Schoutens, André; Bidaut, Luc; Luxen, André; Mendelwicz, Julien

doi:10.1016/0006-3223(94)00189-a

Cited by 102 publications

(76 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With regards to functional and morphological changes in the brains of females with AN, some studies have affirmed that the hypoactivity found in the right parietal cortex of these patients (Delvenne, Goldman, Biver, et al, 1997;Delvenne, Goldman, De Maertelaer, & Lotstra, 1999;Delvenne, Goldman, De Maertelaer, et al, 1997;Delvenne et al, 1995;Nozoe et al, 1993Nozoe et al, , 1995 and the hypoactivity found in the anterior cingulated cortex (Kojima et al, 2005;Naruo et al, 2001) reverted after weight gain (Delvenne et al, 1996;Miller et al, 2004), while others found the opposite results (Kojima et al, 2005;Van Kuyk et al, 2009). The cerebral areas most commonly associated with impaired functioning in patients with AN are the parietal cortex, ventromedial prefrontal cortex, gyrus lingualis within the occipital cortex, medial prefrontal cortex, cerebellum, nucleus caudatus, and insula (Grunwald et al, 2001;Sachdev, Mondraty, Wen, & Gulliford, 2008).…”

Section: Brain Structurementioning

confidence: 98%

Neuropsychological Impairments in Anorexia Nervosa: A Spanish Sample Pilot Study

Oltra-Cucarella

Espert

Rojo

et al. 2013

Applied Neuropsychology: Adult

View full text Add to dashboard Cite

This work was aimed at obtaining a profile of neuropsychological impairments in young Spanish participants with anorexia nervosa (AN) to demonstrate that right-hemisphere and frontal capacity impairments are present not only in the acute phase but also after weight recovery in a Spanish sample compared with a healthy control group. Twelve patients with AN in the acute phase (body mass index [BMI] < 17) were compared both to 16 healthy control subjects and 12 weight-recovered AN participants (BMI ! 17) matched by age, IQ, and educational level by utilizing a wide neuropsychological battery. Differences were found between AN groups only for long-term verbal memory, which worsens as BMI increases. Among participants with AN as a group, results showed differences in speed of information processing, working memory, visual memory, and inhibition, unrelated to attentional capabilities. We cannot support the hypothesis of a specific right cerebral dysfunction in patients with AN. A general cognitive dysfunction, primarily in information processing, working memory, visual and verbal memory, as well as frontal impairments such as impulsivity and poor behavioral control, appeared unrelated to BMI. We support previous works affirming that neuropsychological impairments in AN are not a consequence of the illness but a risk factor for it to develop.

show abstract

Section: Brain Structurementioning

confidence: 98%

Neuropsychological Impairments in Anorexia Nervosa: A Spanish Sample Pilot Study

Oltra-Cucarella

Espert

Rojo

et al. 2013

Applied Neuropsychology: Adult

View full text Add to dashboard Cite

show abstract

“…Other studies, using PET with (18-F)-fluorodeoxyglucose (FDG) (Delvenne et al, 1995) or SPECT (Chowdhury et al, 2003;Gordon et al, 1997;Kuruoqlu et al, 1998;Nozoe et al, 1995;Rastam et al, 2001;Takano et al, 2001) have investigated 'baseline' brain metabolism in ill AN and reported parietal, temporal, and frontal lobe changes in ill AN. When both regions were investigated, both tended to be involved.…”

Section: Only Rec An Have Reduced [mentioning

confidence: 99%

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Bailer

Price

Meltzer

et al. 2004

Neuropsychopharmacol

154

107

View full text Add to dashboard Cite

Several lines of evidence suggest that a disturbance of serotonin neuronal pathways may contribute to the pathogenesis of anorexia nervosa (AN) and bulimia nervosa (BN). This study applied positron emission tomography (PET) to investigate the brain serotonin 2A (5-HT 2A ) receptor, which could contribute to disturbances of appetite and behavior in AN and BN. To avoid the confounding effects of malnutrition, we studied 10 women recovered from bulimia-type AN (REC AN-BN, 41 year normal weight, regular menstrual cycles, no binging, or purging) compared with 16 healthy control women (CW) using PET imaging and a specific 5-HT 2A 18 F]altanserin binding potential and drive for thinness in several cortical regions. In conclusion, this study extends research suggesting that altered 5-HT neuronal system activity persists after recovery from bulimia-type AN, particularly in subgenual cingulate regions. Altered 5-HT neurotransmission after recovery also supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of eating disorders. It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects.

show abstract

“…2 Functional imaging indicates that parietal activity at rest is generally decreased before and increased after treatment. 3,4 Symptom provocation further decreases parietal activity in currently ill patients. 5 It is tempting to relate parietal dysfunction to symptoms of anorexia nervosa because the parietal cortex is the brain region where both proprioceptive and visual information of one's own body are integrated and where appetitive and foodrelated behaviours are processed.…”

Section: Introductionmentioning

confidence: 98%

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa

Bär

Cruz

Berger

et al. 2015

jpn

View full text Add to dashboard Cite

Brain hypometabolism of glucose in anorexia nervosa: A PET scan study

Cited by 102 publications

References 52 publications

Neuropsychological Impairments in Anorexia Nervosa: A Spanish Sample Pilot Study

Neuropsychological Impairments in Anorexia Nervosa: A Spanish Sample Pilot Study

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa

Contact Info

Product

Resources

About