Brain Hypometabolism in Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome

Jeong, Byoung-Min; Shin, Byoung‐Soo; Seo, Man-Wook; Park, Ji-Yun; Jeong, Hwan-Jeong; Oh, Sun-Young

doi:10.21790/rvs.2017.16.4.156

Cited by 1 publication

(4 citation statements)

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“…Brain 18 F‐FDG in CANVAS showed cerebellar hypometabolism in 4/5 patients of our series, and 3/4 of the literature. Concerning other regions, we found cingulate cortex and insular‐opercular cortex hypometabolism in three cases, whereas in the literature, two cases were reported with respectively thalamus and cingulate cortex hypometabolism, and sylvian fissure and part of the frontal cortex hypometabolism 7–9 . Two brain perfusion SPECT showed a decreased cerebral blood flow in the cerebellum 3,7 .…”

Section: Introductionmentioning

confidence: 60%

“…Little data are currently available regarding the contribution of molecular imaging to diagnosing CANVAS. To our knowledge, only 10 cases of DaT SPECT have been reported 3–7 and only four detailed brain 18 F‐FDG PET 7–9 . This note summarizes and highlights the main SPECT and PET findings in CANVAS based on our experience enriched by the literature.…”

Section: Introductionmentioning

confidence: 81%

“…Concerning other regions, we found cingulate cortex and insular-opercular cortex hypometabolism in three cases, whereas in the literature, two cases were reported with respectively thalamus and cingulate cortex hypometabolism, and sylvian fissure and part of the frontal cortex hypometabolism. [7][8][9] Two brain perfusion SPECT showed a decreased cerebral blood flow in the cerebellum. 3,7 None of the subjects had brainstem or striatum hypometabolism.…”

Section: Case Seriesmentioning

confidence: 99%

“…To our knowledge, only 10 cases of DaT SPECT have been reported [3][4][5][6][7] and only four detailed brain 18 F-FDG PET. [7][8][9] This note summarizes and highlights the main SPECT and PET findings in CANVAS based on our experience enriched by the literature.…”

Section: Introductionmentioning

confidence: 97%

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Molecular Imaging in CANVAS: A Contribution for Differential Diagnosis?

Horowitz,

Guedj,

Eusebio

et al. 2024

Movement Disord Clin Pract

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BackgroundPhenotypes of CANVAS are increasingly diversified, including bradykinesia and dysautonomia, so that its primary differential diagnoses are multiple system atrophy‐cerebellar type (MSA‐c), and spinocerebellar ataxia type 3 (SCA3). This case series aims to highlight key molecular imaging findings in CANVAS.CasesWe report a case series of six patients with CANVAS who underwent nuclear medicine examinations in our center and 13 patients from the literature. These include 18F‐FDG brain positron emission tomography (PET), single photon emission computed tomography (SPECT) of dopamine transporter (DaT) activity, and 123I‐MIBG cardiac scintigraphy of noradrenergic transmission.ConclusionsIn CANVAS, 18F‐FDG brain PET mainly shows cerebellar hypometabolism, with preserved brainstem and striatum metabolism, contrasting with SCA3 and MSA‐c. Dopaminergic denervation on scintigraphy seems to be associated with clinical parkinsonism, ranging from normal to severely impaired DaT SPECT. Additionally, 123I‐MIBG cardiac scintigraphy might show denervation in CANVAS, similar to SCA3, but not in most MSA‐c patients.

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Section: Introductionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 81%