Brain histamine response to stress in 12 month old rats

Mazukiewicz-Kwilecki, I.M.; Prell, George D.

doi:10.1016/0024-3205(86)90641-7

Cited by 21 publications

(9 citation statements)

References 45 publications

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“…Early experimental evidence has shown that hypothalamic histamine significantly increases in rats exposed to acute stress [70,71]. In addition, it was found that acute stress increased the histamine level in the rat cerebral cortex [72], diencephalon, and nucleus accumbens (NAc) [73].…”

Section: Depressionmentioning

confidence: 99%

The human histaminergic system in neuropsychiatric disorders

Shan

Bao

Swaab

2015

Trends in Neurosciences

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Section: Depressionmentioning

confidence: 99%

The human histaminergic system in neuropsychiatric disorders

Shan

Bao

Swaab

2015

Trends in Neurosciences

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“…Rodents exposed to stressful situations show abnormally high histamine turnover rates in the brain (Taylor and Snyder, 1971; Kobayashi and Kopin, 1974; Mazurkiewickz‐Kwilecki, 1979; Mazurkiewickz‐Kwilecki and Prell, 1986; Yoshitomi et al. , 1986), whereas several anxiolytic drugs decrease this rate (Oishi et al.…”

Section: Introductionmentioning

confidence: 99%

Altered histamine H₃ receptor radioligand binding in post‐mortem brain samples from subjects with psychiatric diseases

Jin

Anichtchik

Panula

2009

British J Pharmacology

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Background and purpose:Histamine is a modulatory neurotransmitter in the brain. Auto-and hetero-histamine H3 receptors are present in human brain and are potential targets of antipsychotics. These receptors may also display disease-related abnormalities in psychiatric disorders. Here we have assessed how histamine H3 receptors in human brain may be affected in schizophrenia, bipolar disorder, major depression. Experimental approach: Histamine H3 receptor radioligand binding assays were applied to frozen post-mortem prefrontal and temporal cortical sections and anterior hippocampal sections from subjects with schizophrenia, bipolar disorder, major depression and matched controls. Key results: Compared with the controls, increased H3 receptor radioligand binding was found in dorsolateral prefrontal cortex of schizophrenic subjects (especially the ones who were treated with atypical antipsychotics), and bipolar subjects with psychotic symptoms. No differences in H3 receptor radioligand binding were found in the temporal cortex. In hippocampal formation of control subjects, H3 receptor radioligand binding was prominent in dentate gyrus, subiculum, entorhinal cortex and parasubiculum. Decreased H3 binding was found in the CA4 area of bipolar subjects. Decreased H3 binding in CA2 and presubiculum of medication-free bipolar subjects was also seen. Conclusions and implications:The results suggest that histamine H3 receptors in the prefrontal cortex take part in the modulation of cognition, which is impaired in schizophrenic subjects and bipolar subjects with psychotic symptoms. Histamine H3 receptors probably regulate connections between hippocampus and various cortical and subcortical regions and could also be involved in the neuropathology of schizophrenia and bipolar disorder.

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“…Currently, information on the mechanism(s) responsible for SIHA is still insufficient. Despite the accumulating evidence that histamine turnover is altered under physiological stress [4], the level of involvement of histaminergic mechanisms in response to stress has not been estimated.…”

Section: Introductionmentioning

confidence: 99%

Forced Swimming Stress-Related Hypoalgesia:Nondependence on the Histaminergic Mechanisms

Ibironke

Rasak

2013

Neurophysiology

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In experiments on mice, we examined the effects of 3-min-long forced swimming sessions on indices characterizing the state of the nociceptive system. Thirty minutes after the forced swimming episode, significantly lower (P < 0.05) latencies of motor reactions in the hot plate and tail flick tests were observed. At the same time, times of licking the paw within the early and late phases of the formalin test, as well as numbers of writhings in the acetic acid test, became significantly (P < 0.05) smaller. Thus, forced swimming-induced stress results in the development of a hypoalgesia state with respect to thermoinduced pain and chemoinduced somatic (formalin test) and visceral (acetic acid test) pain. Blockers of histamine H1 (cimetidine, 10 mg/kg) and H2 (chlorpheniramine, 15 mg/kg) receptors did not influence significantly (P > 0.05) the intensity of forced swimming-induced hypoalgesia in the tail flick and acetic acidinduced (writhing) tests. Thus, the histaminergic system is not significantly involved in the mechanisms of forced swimming-induced hypoalgesia.

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Brain histamine response to stress in 12 month old rats

Cited by 21 publications

References 45 publications

The human histaminergic system in neuropsychiatric disorders

The human histaminergic system in neuropsychiatric disorders

Altered histamine H₃ receptor radioligand binding in post‐mortem brain samples from subjects with psychiatric diseases

Forced Swimming Stress-Related Hypoalgesia:Nondependence on the Histaminergic Mechanisms

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Brain histamine response to stress in 12 month old rats

Cited by 21 publications

References 45 publications

The human histaminergic system in neuropsychiatric disorders

The human histaminergic system in neuropsychiatric disorders

Altered histamine H3 receptor radioligand binding in post‐mortem brain samples from subjects with psychiatric diseases

Forced Swimming Stress-Related Hypoalgesia:Nondependence on the Histaminergic Mechanisms

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Altered histamine H₃ receptor radioligand binding in post‐mortem brain samples from subjects with psychiatric diseases